Article
Cell Biology
Elisa Negroni, Maria Kondili, Laura Muraine, Mona Bensalah, Gillian Sandra Butler-Browne, Vincent Mouly, Anne Bigot, Capucine Trollet
Summary: Skeletal muscle is a highly plastic tissue that participates in the maintenance, regeneration, and repair of muscles through the interaction and communication of heterogeneous cell populations. Fibro-Adipogenic Progenitors (FAPs) are crucial in muscle homeostasis and regeneration, as they interact with other cells and dynamically remodel the extracellular matrix.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xu Cheng, Yixuan Huang, Yingmeng Liu, Jinfeng Dou, Ning Zhao, Jingtao Li, Bing Shi
Summary: Branchiomeric head muscle and somitic limb muscle present distinct regenerative characteristics, with the fibrosis mechanism in head muscle still elusive. FAPs play a persistent role in head muscle regeneration, possibly contributing to fibrosis due to their prolonged presence in the early regeneration stages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cell Biology
Taryn Loomis, Lucas R. Smith
Summary: This review summarizes the role of fibro-adipogenic progenitors (FAPs) in muscle fibrosis, including their activation, heterogeneity, and contribution to muscle fibrotic degeneration, and discusses current research on potential therapeutic avenues targeting FAPs.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Thomas Molina, Paul Fabre, Nicolas A. Dumont
Summary: Skeletal muscle regeneration relies on the coordination between muscle stem cells and fibro-adipogenic progenitors (FAPs), with FAPs playing a crucial role by supporting myogenic activity and exhibiting cellular heterogeneity.
Review
Developmental Biology
Brittany C. Collins, Gabrielle Kardon
Summary: Vertebrate skeletal muscle is composed of multinucleate myofibers surrounded by muscle connective tissue, and can robustly regenerate following injury through satellite cells. Satellite cells and FAPs are heterogeneous cell populations, with current understanding focusing on gene expression, anatomical location, age, and timing during the regenerative process.
Article
Cell & Tissue Engineering
Francesca Boscolo Sesillo, Varsha Rajesh, Michelle Wong, Pamela Duran, John B. Rudell, Courtney P. Rundio, Brittni B. Baynes, Louise C. Laurent, Alessandra Sacco, Karen L. Christman, Marianna Alperin
Summary: Pelvic floor muscle injury during childbirth is a key risk factor for pelvic floor disorders. Muscle stem cells, fibro-adipogenic progenitors, and immune cells play important roles in the regeneration of injured pelvic floor muscles. The loss of function and decreased expansion of muscle stem cells and fibro-adipogenic progenitors after birth injury lead to impaired pelvic floor muscle recovery.
NPJ REGENERATIVE MEDICINE
(2022)
Review
Cell Biology
X. Wei, C. Nicoletti, P. L. Puri
Summary: This article discusses the emerging contribution of FAPs to skeletal muscle responses to motor neuron injuries and systemic physiological or pathological metabolic perturbations, providing an initial blueprint of discrete sub-clusters of FAPs activated by specific perturbations and their role in muscle adaptation to these conditions.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Marielle Saclier, Giuseppe Angelini, Chiara Bonfanti, Giada Mura, Giulia Temponi, Graziella Messina
Summary: Macrophages expressing the transcription factor Nfix play a role in fibrosis and muscle wasting in muscular dystrophies. Inhibiting Nfix in macrophages delays fibrosis and muscle wasting, increasing grip strength. Treatment with a ROCK inhibitor accelerates fibrosis by increasing Nfix expression in macrophages.
JOURNAL OF PATHOLOGY
(2022)
Article
Cell & Tissue Engineering
Georgios Kotsaris, Taimoor H. H. Qazi, Christian H. H. Bucher, Hafsa Zahid, Sophie Poehle-Kronawitter, Vladimir Ugorets, William Jarassier, Stefan Boerno, Bernd Timmermann, Claudia Giesecke-Thiel, Aris N. N. Economides, Fabien Le Grand, Pedro Vallecillo-Garcia, Petra Knaus, Sven Geissler, Sigmar Stricker
Summary: Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are essential for providing a beneficial microenvironment for muscle stem cells (MuSCs) during muscle regeneration. The transcription factor Osr1 plays a central role in coordinating muscle regeneration by enabling communication between FAPs, MuSCs, and infiltrating macrophages, as well as orchestrating key regenerative events such as inflammation, matrix secretion, and myogenesis.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Olga Mucha, Paulina Podkalicka, Monika Zukowska, Ewelina Pospiech, Jozef Dulak, Agnieszka Loboda
Summary: Skeletal muscle regeneration is influenced by the interaction between different types of cells. Deletion of miR-378 affects the abundance of muscle satellite cells and the adipogenic potential of fibro-adipogenic progenitors, but does not impact overall regeneration upon acute glycerol-induced muscle injury.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Junfang Zhang, Qiang Li, Yan Yan, Bin Sun, Ying Wang, Lin Tang, Enze Wang, Jia Yu, Kim Margarette Corpuz Nogoy, Xiangzi Li, Seong-Ho Choi
Summary: The study reveals that ciglitazone acts as a PPAR gamma agonist, effectively increasing adiponectin concentration and adipogenic gene expression, promoting the conversion of BSC to adipocyte-like cells in the absence of an adipocyte differentiation cocktail. This finding may contribute to research on adipocytes without the use of differentiation mixtures.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Erica Martins Ferreira Gotardo, Thaina Rodrigues de Morais, Ana Paula Timoteo Ferreira, Cintia Rabelo e Paiva Caria, Marcelo Lima Ribeiro, Alessandra Gambero
Summary: Several studies have shown that deferoxamine, an iron chelator, can improve inflammation in adipose tissue caused by obesity. This study analyzed the effects of deferoxamine on fibro-inflammation in adipose tissue during diet-induced obesity in mice and conducted in vitro experiments with fibroblasts and macrophages to understand its activity.
CURRENT DRUG TARGETS
(2023)
Review
Pharmacology & Pharmacy
Wan-Jiao Gao, Jian-Xin Liu, Meng-Nan Liu, Yun-Da Yao, Zhong-Qiu Liu, Liang Liu, Huan-Huan He, Hua Zhou
Summary: Macrophages are heterogeneous cells with various physiological functions, including migration which plays a crucial role in the progression of inflammatory diseases, autoimmune diseases, and cancers. Research indicates that macrophage migration in three-dimensional environments is associated with disease pathology, suggesting it as a potential therapeutic target.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
X. Xu, Y. Chu, Y. Zhang, G. Li, P. Yang, J. Zhang, J. Duan, H. Yang, H. Xu, M. Wang
Summary: The study demonstrates that unilateral anterior crossbite can promote adipogenic differentiation of chondrocytes and result in cartilage softening and proteoglycan loss.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Oscar Horwath, Fabian Nordstrom, Ferdinand von Walden, William Apro, Marcus Moberg
Summary: Cumulative evidence supports the hypothesis that hypoxia acts as a regulator of muscle mass. This study examined the effect of hypoxia on signaling pathways and gene expression in human skeletal muscle after resistance exercise. The results showed that hypoxia attenuated ribosome signaling but did not affect satellite cell pool expansion and myogenic gene expression.