Metal-free SERS: Where we are now, where we are heading

In the recent years, the emergence of metal-free surface-enhanced Raman scattering (SERS) substrates has provided promising alternatives for reliable, high-sensitivity Raman spectroscopy due to their potential to realize highly tuneable, biocompatible, and reproducible Raman enhancement. In this perspective article, we discuss recent developments and anticipate new opportunities for metal-free SERS. Specifically, we review the theory of metal-free SERS, including electromagnetic enhancement and chemical enhancement, and introduce promising substrates developed recently, including MXenes, transition metal dichalcogenides, and carbon-based substrates. Moreover, we clarify challenges, provide potential solutions, and discuss unexploited applications. This perspective provides not only a broad and detailed view of metal-free SERS at the current stage, but also a roadmap for its future advancement. Copyright (C) 2022 EPLA

Automated summary

The emergence of metal-free surface-enhanced Raman scattering (SERS) substrates has provided promising alternatives for reliable, high-sensitivity Raman spectroscopy. This perspective article reviews the theory of metal-free SERS, introduces promising substrates, clarifies challenges, provides potential solutions, and discusses unexploited applications.