Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis

(2021) Hiroyuki Ogawa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparative evaluation of cardiovascular risks among nine FDA-approved VEGFR-TKIs in patients with solid tumors: a Bayesian network analysis of randomized controlled trials

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Cardiovascular Toxicities of Antiangiogenic Tyrosine Kinase Inhibitors: A Retrospective, Pharmacovigilance Study

(2021) Adam Goldman et al.   Targeted Oncology

Pseudo toxicity abatement effect of norfloxacin and copper combined exposure on Caenorhabditis elegans

(2021) Lili Liu et al.   CHEMOSPHERE

Protein fucosylation is required for Notch dependent vascular integrity in zebrafish

(2021) Gerissa Fowler et al.   DEVELOPMENTAL BIOLOGY

Exposure to diclofop-methyl induces cardiac developmental toxicity in zebrafish embryos

(2020) Zigang Cao et al.   ENVIRONMENTAL POLLUTION

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart

(2020) Xueyu Li et al.   Protein & Cell

Hypertensive Cardiotoxicity in Cancer Treatment—Systematic Analysis of Adjunct, Conventional Chemotherapy, and Novel Therapies—Epidemiology, Incidence, and Pathophysiology

(2020) Robin Chung et al.   Journal of Clinical Medicine

Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism

(2019) Long Zhao et al.   Cell Reports

Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

(2019) Thomas Senoner et al.   Nutrients

Efficacy of Lenvatinib, a multitargeted tyrosine kinase inhibitor, on laser-induced CNV mouse model of neovascular AMD

(2018) Xian Wei et al.   EXPERIMENTAL EYE RESEARCH

Notch and interacting signalling pathways in cardiac development, disease, and regeneration

(2018) Donal MacGrogan et al.   Nature Reviews Cardiology

Associations of GATA4 genetic mutations with the risk of congenital heart disease

(2017) Yanwei Zhang et al.   MEDICINE

Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart

(2017) Silvia Nistri et al.   Frontiers in Pharmacology

Chemical and toxicological characterisation of anticancer drugs in hospital and municipal wastewaters from Slovenia and Spain

(2016) Marina Isidori et al.   ENVIRONMENTAL POLLUTION

Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives

(2016) Ricardo Costa et al.   Drug Design Development and Therapy

An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood

(2015) Vanessa George et al.   DEVELOPMENTAL BIOLOGY

Acute and sub-chronic toxicity of four cytostatic drugs in zebrafish

(2015) Róbert Kovács et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer

(2015) Martin Schlumberger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nkx genes are essential for maintenance of ventricular identity

(2013) K. L. Targoff et al.   DEVELOPMENT

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours

(2012) D S Boss et al.   BRITISH JOURNAL OF CANCER

Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development

(2009) Jae-Sun Park et al.   DEVELOPMENTAL DYNAMICS