Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARβ: In Vivo, In Vitro, and In Silico Investigations

System Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle

(2021) Tengfei Xu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways

(2021) Xiaoqing Wang et al.   ACS Sustainable Chemistry & Engineering

Cytoplasmic phosphorylated ERK1/2 expression in patients with melanoma is associated with tumor stage and metastasis

(2021) Yen-Shuo Tseng et al.   BIOTECHNIC & HISTOCHEMISTRY

Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant

(2021) Wei Guo et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Developing QSAR Models with Defined Applicability Domains on PPARγ Binding Affinity Using Large Data Sets and Machine Learning Algorithms

(2021) Zhongyu Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Deciphering the oxygen activation mechanism at the CuC site of particulate methane monooxygenase

(2021) Wei Peng et al.   Nature Catalysis

Life Cycle Exposure to Environmentally Relevant Concentrations of Diphenyl Phosphate (DPhP) Inhibits Growth and Energy Metabolism of Zebrafish in a Sex-Specific Manner

(2021) Qiliang Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Stage Dependent Enantioselective Metabolism of Bifenthrin in Embryos of Zebrafish (Danio rerio) and Japanese Medaka (Oryzias latipes)

(2021) Chenyang Ji et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

2,6-Di-tert-butylphenol and its quinone metabolite trigger aberrant transcriptional responses in C57BL/6 mice liver

(2021) Shixuan Cui et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis

(2021) François Sipieter et al.   iScience

Rat Metabolism Study Suggests 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic Acid as a Potential Urinary Biomarker of Human Exposure to Representative 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate Antioxidants

(2021) Runzeng Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers

(2021) Weitao Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of an environmentally relevant PFAS mixture on dopamine and steroid hormone levels in exposed mice

(2021) Randi Grønnestad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

(2020) Kamel Mansouri et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Inhibited Nitric Oxide Production of Human Endothelial Nitric Oxide Synthase by Nitrated and Oxygenated Polycyclic Aromatic Hydrocarbons

(2020) Hao Wu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of prenatal bisphenol A exposure on the hepatic transcriptome and proteome in rat offspring

(2020) Hoa Thanh Nguyen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

ERK/MAPK signalling pathway and tumorigenesis (Review)

(2020) Yan‑Jun Guo et al.   Experimental and Therapeutic Medicine

Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption

(2020) Dries Knapen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Fluoroacetate dehalogenase catalyzed dehalogenation of halogenated carboxylic acids: A QM/MM approach

(2020) Yue Yue et al.   CHEMOSPHERE

Synthetic Phenolic Antioxidants: A Review of Environmental Occurrence, Fate, Human Exposure, and Toxicity

(2020) Runzeng Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Pentabromoethylbenzene Exposure Induces Transcriptome Aberration and Thyroid Dysfunction: In Vitro, in Silico, and in Vivo Investigations

(2020) Liping Lu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Targeting the epigenetic regulation of antitumour immunity

(2020) Simon J. Hogg et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects

(2020) Min Liu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion

(2020) Kamolrat Somboon et al.   Nature Communications

Effects of corexit 9500A and Corexit-crude oil mixtures on transcriptomic pathways and developmental toxicity in early life stage mahi-mahi (Coryphaena hippurus)

(2019) Justin B. Greer et al.   AQUATIC TOXICOLOGY

Whole-Transcriptome Sequencing of Epidermal Mucus as a Novel Method for Oil Exposure Assessment in Juvenile Mahi-Mahi (Coryphaena hippurus)

(2019) Justin B. Greer et al.   Environmental Science & Technology Letters

Competitive Biotransformation Among Phenolic Xenobiotic Mixtures: Underestimated Risks for Toxicity Assessment

(2019) Bo Peng et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Key characteristics of 86 agents known to cause cancer in humans

(2019) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

The molecular mechanism of the antagonistic activity of hydroxylated polybrominated biphenyl (OH-BB80) toward thyroid receptor β

(2019) Xiaofang Zhang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Proteomic approaches beyond expression profiling and PTM analysis

(2018) Jiaqi Fu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Application of the key characteristics of carcinogens in cancer hazard identification

(2018) Kathryn Z Guyton et al.   CARCINOGENESIS

Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro: A Case Study with Cyproconazole

(2018) Claudia Luckert et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The evaluation of endocrine disrupting effects of tert -butylphenols towards estrogenic receptor α, androgen receptor and thyroid hormone receptor β and aquatic toxicities towards freshwater organisms

(2018) Jiaying Wang et al.   ENVIRONMENTAL POLLUTION

A Cross-species Quantitative Adverse Outcome Pathway for Activation of the Aryl Hydrocarbon Receptor Leading to Early Life Stage Mortality in Birds and Fishes

(2018) Jon A. Doering et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Synthetic Phenolic Antioxidants and Their Metabolites in Sediments from the Coastal Area of Northern China: Spatial and Vertical Distributions

(2018) Xiaoyun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Cyclooxygenase-2 in cancer: A review

(2018) Nasser Hashemi Goradel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Application of Adverse Outcome Pathways to U.S. EPA’s Endocrine Disruptor Screening Program

(2017) Patience Browne et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology

(2017) Rory B. Conolly et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Interactions of benzotriazole UV stabilizers with human serum albumin: Atomic insights revealed by biosensors, spectroscopies and molecular dynamics simulations

(2016) Shulin Zhuang et al.   CHEMOSPHERE

Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

(2015) Bing Liu et al.   Cancer Cell International

Different senescent HDPE pipe-risk: brief field investigation from source water to tap water in China (Changsha City)

(2015) Jing Tang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

(2015) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The nuclear translocation of ERK1/2 as an anticancer target

(2015) Alexander Plotnikov et al.   Nature Communications

Molecular Link Mechanisms between Inflammation and Cancer

(2012) D. B. Vendramini-Costa et al.   CURRENT PHARMACEUTICAL DESIGN

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

(2012) J. Osz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic metabolism of retinoids and disease associations

(2011) Yohei Shirakami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.

(2011) Nathan A. Lack et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long-term study of migration of volatile organic compounds from cross-linked polyethylene (PEX) pipes and effects on drinking water quality

(2011) Vidar Lund et al.   JOURNAL OF WATER AND HEALTH

R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments

(2011) Enguerran Vanquelef et al.   NUCLEIC ACIDS RESEARCH