期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 226, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2021.112854
关键词
Glyphosate; Aminomethyl phosphonic acid; Zebrafish; Development; Toxicity
资金
- National Natural Science Foundation of China [81872628]
- Natural Science Foundation of Hebei Province [H 2018206122]
- Postdoctoral Foundation of Hebei Province [B 2021003046]
This study evaluated the effects of residual low-concentrations of Glyphosate (GLY) and its degradation product AMPA on zebrafish embryos, finding developmental toxicity including increased heart rates, arrhythmia, cardiac defects, and altered gene transcription levels. Pericardial edema and bone deformation may be caused by inhibition of specific enzymes after exposure to GLY and AMPA. The results suggest that typical environmental residual concentrations of GLY and AMPA have similar developmental toxicity in zebrafish embryos.
Glyphosate (GLY) is the most widely used broad-spectrum, non-selective herbicide in the world, whose main degradation product is aminomethyl phosphonic acid (AMPA). Because of long-term and large-scale use, residual GLY and AMPA in the environment pose great environmental and human health threats. The purpose of this study is to evaluate the effects and mechanism of residual low-concentrations of GLY and AMPA in the environment on the development of zebrafish embryos. Zebrafish embryos were exposed to 0, 1, 10, 100, and 700 ng.mL- 1 GLY and AMPA for 72 h (from 2 to 74 h post-fertilization). With increasing exposure dose, heart rates of both embryos and larvae showed a rising trend and obvious arrhythmia appeared. Defects in cardiac development and function of zebrafish juveniles may be related to altered transcription levels of cardiac development genes (TBX5, NKX2.5, BMP4) and apoptosis genes (Bcl-2, Bax). In addition, pericardial edema and bone deformation of zebrafish embryos may be caused by inhibition of Na+/K+-ATPase and Ca2+-ATPase after exposure to GLY and AMPA. The present results demonstrated that at typical environmental residual concentrations of GLY and AMPA had similar developmental toxicity in zebrafish embryos.
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