Article
Pediatrics
Sarah Sturrock, Hemant Ambulkar, Emma E. Williams, Samantha Sweeney, Nadja F. Bednarczuk, Theodore Dassios, Anne Greenough
Summary: The study showed that using a closed loop automated oxygen control system can reduce the duration and severity of desaturation episodes in preterm, ventilated infants, increase the time spent in the targeted oxygen range, and decrease the number of manual adjustments made to the inspired oxygen concentration.
Article
Pediatrics
Ourania Kaltsogianni, Theodore Dassios, Rebecca Lee, Christopher Harris, Anne Greenough
Summary: This study aimed to determine if using closed-loop automated oxygen control (CLAC) can reduce the incidence and duration of hypoxemic episodes in ventilated infants born at or above 34 weeks of gestation. The results showed that CLAC resulted in less time spent in hypoxemia, shorter episodes of desaturation, increased time spent in the target SpO(2) range, and lower FiO(2) delivery. It also reduced time spent in hyperoxemia, shorter episodes of hyperoxemia, and fewer manual adjustments made to the FiO(2).
Article
Sport Sciences
Jenna B. Wowdzia, Tom J. Hazell, Emily R. Vanden Berg, Lawrence Labrecque, Patrice Brassard, Margie H. Davenport
Summary: This study compared the cardiovascular responses of pregnant women and fetuses to acute bouts of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT). The results showed that both HIIT and MICT were well tolerated by both the mother and fetus during exercise.
Article
Psychology, Biological
Leonard H. Epstein, Sara O'Donnell, Mathew J. Biondolillo, David Hostler, James N. Roemmich
Summary: Exercise is a strong reinforcer for both animals and humans, with HIIT being shown to have a higher reinforcing value compared to MIAE. Inactive individuals may find HIIT more rewarding and may be more likely to adopt and maintain an exercise program involving HIIT rather than MIAE. Further research is needed to understand how to enhance the reinforcing value of exercise to encourage sedentary individuals to be more active.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Medicine, General & Internal
Philipp K. Buehler, Anique Herling, Nadine Bienefeld, Stephanie Klinzing, Stephan Wegner, Pedro David Wendel Garcia, Michael Karbach, Quentin Lohmeyer, Elisabeth Schaubmayr, Reto A. Schuepbach, Daniel A. Hofmaenner
Summary: The study found that intensive care nurses mainly focus on numeric values and settings, with high interest in areas related to traditional mechanical ventilation. Experienced nurses pay more attention to oxygenation Intellivent and ventilation Intellivent, indicating greater familiarity with closed-loop modes in this group.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Richard A. Bell, James C. Baldi, Lynnette M. Jones
Summary: The study compared the effects of high-intensity interval training (HIIT) and continuous moderate-intensity training (MICT) on aerobic capacity in BC survivors. Results showed that transitioning to moderate/high-intensity exercise can lead to clinically relevant increases in VO(2)peak in previously trained BC survivors.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Endocrinology & Metabolism
Emilie Bundgaard Lindkvist, Christian Laugesen, Asbjorn Thode Reenberg, Tobias Kasper Skov Ritschel, Jannet Svensson, John Bagterp Jorgensen, Kirsten Norgaard, Ajenthen G. G. Ranjan
Summary: This study compared the efficacy and safety of a dual-hormone closed-loop system (insulin and glucagon) with a single-hormone closed-loop system (insulin only) in adolescents with type 1 diabetes. The results showed that overall, both systems performed similarly in controlling blood glucose levels during a 26-hour monitoring period. However, the single-hormone system outperformed the dual-hormone system during the night and during exercise.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Ozlem Sandal, Gokhan Ceylan, Sevgi Topal, Pinar Hepduman, Mustafa Colak, Dominik Novotni, Ekin Soydan, Utku Karaarslan, Gulhan Atakul, Marcus J. Schultz, Hasan Agin
Summary: Closed-loop oxygen control improves oxygenation therapy in pediatric patients receiving high-flow nasal oxygen therapy for acute hypoxemic respiratory failure (AHRF), potentially leading to more efficient oxygen use and reduced workload for healthcare providers.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Su-Kiat Chua, Wen-Ling Chen, Lung-Ching Chen, Kou-Gi Shyu, Huei-Fong Hung, Shih-Huang Lee, Tzu-Lin Wang, Wei-Ting Lai, Kuan-Jen Chen, Zhen-Yu Liao, Cheng-Yen Chuang, Ching-Yao Chou
Summary: This study compared the effectiveness of closed-loop stimulation (CLS) pacing with traditional DDD mode pacing in patients with chronotropic incompetence (CI). The results showed that CLS pacing significantly improved exercise capacity and quality of life in these patients, highlighting its potential as an effective pacing strategy.
Article
Endocrinology & Metabolism
Julia Lawton, Ruth I. Hart, Barbara Kimbell, Janet M. Allen, Rachel Elizabeth Jane Besser, Charlotte Boughton, Daniela Elleri, Julia Fuchs, Atrayee Ghatak, Tabitha Randell, Ajay Thankamony, Nicola Trevelyan, Roman Hovorka, David Rankin
Summary: There is considerable variability in how parent-child dyads perceive and undertake data sharing practices, especially between parents and adolescents of different age groups. Clear ground rules are recommended to be put in place for data sharing to minimize conflict and optimize parental support.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Review
Multidisciplinary Sciences
Shuoqi Li, Shazlin Shaharudin, Rafel Cirer-Sastre, Feifei Li, Faizal Abdul Manaf, Mohd Faiz Mohd Shukri
Summary: This systematic review and meta-analysis aimed to compare the effects of high-intensity interval exercise (HIIE) with different recovery modes versus moderate intensity continuous exercise (MICE) on cardiac troponin (cTn) elevation. The results showed no significant difference between HIIE and MICE in the elevation of cardiac troponin T (cTnT). However, HIIE with passive recovery elicited more release of cardiac troponin T (cTnT) than MICE.
Article
Endocrinology & Metabolism
Jack A. Sargeant, Charlotte Jelleyman, Nicole A. Coull, Charlotte L. Edwardson, Joseph Henson, James A. King, Kamlesh Khunti, Matthew McCarthy, Alex V. Rowlands, David J. Stensel, Helen L. Waller, David R. Webb, Melanie J. Davies, Thomas Yates
Summary: There were no significant differences in metabolic responses to LV-HIIE and CME between white Europeans and South Asians with nondiabetic hyperglycemia, but reductions in insulin and insulin resistance after acute exercise were more pronounced in South Asians. Further trials are needed to investigate the long-term impact of LV-HIIE and CME on cardiometabolic health.
Article
Geochemistry & Geophysics
Wu SiYuan, Li ShouDing, Chen Dong, Li Xiao, Du AiMin, Zhang Ying
Summary: The reserves of deep oil and gas resources are huge and significant for global oil and gas development. The method of downhole autonomous intelligent drilling is proposed to address the challenges in deep and ultra-deep drilling operations. By using AI evaluation and decision methods, the system can intelligently identify sweet spots, determine drilling direction and rate of penetration, and navigate the drill bit automatically with global closed-loop servo control.
CHINESE JOURNAL OF GEOPHYSICS-CHINESE EDITION
(2021)
Article
Endocrinology & Metabolism
Ahmad Haidar, Laurent Legault, Marie Raffray, Nikita Gouchie-Provencher, Peter G. Jacobs, Anas El-Fathi, Joanna Rutkowski, Virginie Messier, Remi Rabasa-Lhoret
Summary: The study confirms that automated insulin delivery improves glucose control compared with sensor-augmented pump therapy in adults with type 1 diabetes. The automated insulin delivery system increased time spent within a specific blood glucose range and reduced time spent in hypoglycemia.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Critical Care Medicine
James C. P. Harper, Nethmi A. Kearns, Ingrid Maijers, Grace E. Bird, Irene Braithwaite, Nicholas P. Shortt, Allie Eathorne, Mark Weatherall, Richard Beasley
Summary: The study demonstrates that the novel nasal high-flow device with closed-loop control can respond to changes in S-pO2 outside a target saturation range in a model of exercise-induced desaturation and subsequent recovery.
Editorial Material
Endocrinology & Metabolism
Barbora Paldus, Dale Morrison, Melissa Lee, Dessi P. Zaharieva, Michael C. Riddell, David N. O'Neal
Summary: Exercise has many benefits for people with type 1 diabetes, but there are barriers such as glycemic instability and fear of hypoglycemia. Closed-loop systems have shown benefits in glycemic management, but face challenges in managing insulin needs during exercise. This commentary discusses the principles, strengths, and challenges of closed-loop systems in exercise management, and explores potential approaches to improve their shortcomings for fully automated systems.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Rheumatology
Laura Ross, Benedict Costello, Anniina Lindqvist, Dylan Hansen, Zoe Brown, Wendy Stevens, Andrew Burns, David Prior, Marcus Pianta, Warren Perera, Andre La Gerche, Mandana Nikpour
Summary: This study aimed to quantify the burden of exercise intolerance in systemic sclerosis (SSc) and explore the disease features contributing to impaired exercise capacity. The results showed significantly reduced exercise capacity in SSc patients compared to controls, with diffuse myocardial fibroinflammatory disease and skeletal muscle edema being significantly associated with reduced exercise tolerance. Left ventricular ejection fraction was not associated with impaired exercise capacity.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Multidisciplinary Sciences
Hayley T. Dillon, Stephen Foulkes, Yuki A. Horne-Okano, David Kliman, David W. Dunstan, Robin M. Daly, Steve F. Fraser, Sharon Avery, Bronwyn A. Kingwell, Andre La Gerche, Erin J. Howden
Summary: Premature cardiovascular mortality is increased in long-term allogeneic stem cell transplant survivors. This study compared peak oxygen uptake ( ?VO2peak ) and its determinants between long-term allo-SCT survivors and non-cancer controls. The results showed that survivors had impaired ?VO2peak and reduced exercise cardiac function, as well as increased body fat percentage, highlighting potential therapeutic avenues and the utility of exercise-based cardiovascular assessment in identifying cardiovascular dysfunction in allo-SCT survivors.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Dessi P. Zaharieva, Ransalu Senanayake, Conner Brown, Brendan Watkins, Glenn Loving, Priya Prahalad, Johannes O. Ferstad, Carlos Guestrin, Emily B. Fox, David M. Maahs, David Scheinker
Summary: Stanford University has utilized algorithm-enabled patient prioritization and remote patient monitoring to improve clinical workflows and glucose control in youth with type 1 diabetes. The care model integrates continuous glucose monitoring data and aims to incorporate exercise data to better manage patients' needs and help healthcare professionals make informed decisions. Regular exercise is crucial for cardiovascular fitness and overall well-being, but can impact blood glucose levels. By integrating physical activity metrics, the model aims to identify whether patients are meeting exercise guidelines and provide clinically relevant information.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mathias Claeys, Thibault Petit, Jan Bogaert, Andre La Gerche, Jan Los, Marion Delcroix, Rik Willems, Guido Claessen, Piet Claus
Summary: This study evaluated ventricular interaction during exercise in patients with heart failure with preserved ejection fraction (HFpEF) and chronic thromboembolic pulmonary hypertension (CTEPH). The results showed that exercise amplifies adverse right-left ventricular interactions, particularly in CTEPH patients. The interaction is most pronounced in early diastole and during inspiration. These findings have important implications for diagnosis and treatment.
Editorial Material
Sport Sciences
Guido Claessen, Andre La Gerche, Ruben De Bosscher
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Elizabeth D. Paratz, Ziad Nehme, Dion Stub, Andre La Gerche
Article
Endocrinology & Metabolism
Grant B. Smith, Mary Abraham, Martin de Bock, Janice Fairchild, Bruce R. King, Geoffrey Ambler, Fergus A. Cameron, Sybil C. McAuley, Anthony Keech, Alicia A. Jenkins, Elizabeth N. Davis, David W. O'Neal, Timothy Jones, Australian JDRF Closed Loop Res Grp
Summary: The research aims to explore the impact of missing data on the accuracy of continuous glucose monitoring (CGM) metrics in a clinical trial. Through simulations, it is found that the proportion and block size of missing data affect the agreement of CGM metrics, with a higher proportion of missing data having a more pronounced effect. The study suggests that at least 70% of CGM data should be available over at least 10 days (R-2 > 0.9) for a 14-day CGM data set to be considered representative for percentage time in range (%TIR).
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Laura E. Donaldson, Sara Vogrin, Michelle So, Glenn M. Ward, Balasubramanian Krishnamurthy, Vijaya Sundararajan, Richard J. MacIsaac, Thomas W. H. Kay, Sybil A. McAuley
Summary: This study investigated the correlations between CGM-based composite metrics and standard glucose metrics in individuals with recent-onset and long-duration type 1 diabetes. Fourteen composite metrics focusing on overall glycemia, glycemic variability, and hypoglycemia were identified. The overall glycemia-focused metrics strongly correlated with glucose time in range, while the hypoglycemia-focused metrics were sensitive to automated insulin delivery therapy.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
David Chieng, Hariharan Sugumar, Louise Segan, Caleb Tan, Donna Vizi, Shane Nanayakkara, Ahmed Al-Kaisey, Joshua Hawson, Sandeep Prabhu, Aleksandr Voskoboinik, Sue Finch, Joseph B. Morton, Geoffrey Lee, Justin Mariani, Andre La Gerche, Andrew J. Taylor, Erin Howden, Peter M. Kistler, Jonathan M. Kalman, David M. Kaye, Liang-Han Ling
Summary: This study compared the effects of AF ablation and usual medical therapy on patients with heart failure with preserved ejection fraction (HFpEF) and concurrent atrial fibrillation (AF). It found that AF ablation can improve the severity of HFpEF, including exercise hemodynamics, natriuretic peptide levels, and patient symptoms. AF ablation can alleviate symptoms of heart failure, improve exercise capacity, and enhance quality of life.
JACC-HEART FAILURE
(2023)
Editorial Material
Sport Sciences
Amy Mitchell, Kristel Janssens, Erin J. Howden, Andre La Gerche, Jessica J. Orchard
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Endocrinology & Metabolism
Christel Hendrieckx, Hanafi M. Husin, Sienna Russell-Green, Jennifer A. Halliday, Benjamin Lam, Steven Trawley, Sybil A. Mcauley, Leon A. Bach, Morton G. Burt, Neale D. Cohen, Peter G. Colman, D. Jane Holmes-Walker, Alicia J. Jenkins, Melissa H. Lee, Roland W. Mccallum, Steve N. Stranks, Vijaya Sundararajan, Tim W. Jones, David N. O'Neal, Jane Speight, Australian JDRF Closed Loop Res Grp
Summary: This study examined the psychometric properties of the Diabetes Management Experiences Questionnaire (DME-Q). The results showed that the DME-Q is a brief, reliable measure with satisfactory structural and construct validity, and it is responsive to intervention. This tool could be useful for evaluating new pharmaceutical agents and technologies in research and clinical settings.
Article
Peripheral Vascular Disease
Rachel E. Climie, Hayley T. Dillon, Yuki Horne-Okano, Imogen Wallace, Sharon Avery, Bronwyn A. Kingwell, Andre La Gerche, Erin J. Howden
Summary: This study provides evidence of an accelerated vascular aging phenotype in allogeneic SCT survivors and provides insight into the increased burden of cardiovascular disease among hematologic cancer survivors.
Article
Endocrinology & Metabolism
Emma L. Fisher, Natasha A. Weaver, Alexandra L. Marlow, Bruce R. King, Carmel E. Smart
Summary: This study aimed to investigate the macronutrient intake and its variability in children with Type 1 diabetes (T1D) and explore the associations between fat and protein intakes with glycemic outcomes. The results showed that the consumption of fat and protein at dinner in these children could cause delayed postprandial hyperglycemia, suggesting the need for insulin dose adjustments. The excessive intake of saturated fat also raised the risk of cardiovascular diseases.
PEDIATRIC DIABETES
(2023)