Functional roles of fish collagen peptides on bone regeneration

Fish collagen peptides (FCP) derived from the skin, bones and scales are commercially used as a functional food or dietary supplement for hypertension and diabetes. However, there is limited evidence on the effects of FCP on the osteoblast function in contrast to evidence of the effects on wound healing, diabetes and bone regeneration, which have been obtained from animal studies. In this narrative review, we expound on the availability of FCP by basic research using osteoblasts. Low-concentration FCP upregulates the expression of osteoblast proliferation, differentiation and collagen modifying enzyme-related genes. Furthermore, it could accelerate matrix mineralization. FCP may have potential utility as a biomaterial to improve collagen quality and promote mineralization through the mitogen-activated protein kinase and Smad cascades. However, there are few clinical studies on bone regeneration in human subjects. It is desirable to be applied clinically through clinical study as soon as possible, based on the results from basic research.

Automated summary

Fish collagen peptides (FCP) derived from fish skin, bones, and scales are used as functional food or dietary supplements for hypertension and diabetes. Basic research shows that low-concentration FCP can upregulate osteoblast genes related to proliferation, differentiation, and collagen modification, and accelerate matrix mineralization. There is limited evidence on the effects of FCP on osteoblast function in human bone regeneration, and further clinical studies are needed for potential application.