Article
Cell & Tissue Engineering
Rodrigo Azevedo Loiola, Miguel Garcia-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell, Fabien Gosselet
Summary: The secretome of endothelial progenitor cells from stroke patients (scCM) promotes angiogenesis, migration, and tubulogenesis of endothelial cells while protecting the vascular barrier function, suggesting its potential as a therapeutic alternative for ischemic conditions.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Neurosciences
Nadia Sadanandan, Alex Shear, Beverly Brooks, Madeline Saft, Dorothy Anne Galang Cabantan, Chase Kingsbury, Henry Zhang, Stefan Anthony, Zhen-Jie Wang, Felipe Esparza Salazar, Alma R. Lezama Toledo, German Rivera Monroy, Joaquin Vega Gonzales-Portillo, Alexa Moscatello, Jea-Young Lee, Cesario V. Borlongan
Summary: This article discusses the critical role of BBB permeability in brain metastatic cancer and proposes the hypothesis of using stem cell therapy. Research suggests that attenuating metastatic brain cancers can be achieved by repairing BBB disruptions and reducing brain inflammation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Shuaishuai Gong, Huifen Ma, Fan Zheng, Juan Huang, Yuanyuan Zhang, Boyang Yu, Fang Li, Junping Kou
Summary: The study demonstrated that YAP plays a crucial role in maintaining BBB integrity in ischemic stroke, suggesting its potential as a therapeutic target for modulating BBB integrity in cerebrovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Rais Reskiawan A. Kadir, Mansour Alwjwaj, Ulvi Bayraktutan
Summary: This study comparatively assessed the effect of PKC-beta inhibitor LY333531 on the cerebral barrier integrity formed by OECs or HBMECs. The results showed that LY333531 protected the barrier formed by HBMECs and exacerbated the damage in OECs. Furthermore, a lower concentration of LY333531 (0.01μM) had a smaller impact on the damage.
METABOLIC BRAIN DISEASE
(2022)
Review
Cell Biology
Konstantin N. Yarygin, Daria D. Namestnikova, Kirill K. Sukhinich, Ilya L. Gubskiy, Alexander G. Majouga, Irina V. Kholodenko
Summary: Mesenchymal stem cells transplantation in stroke treatment shows promise, especially with intra-arterial administration. However, further research is needed to understand the interactions between transplanted cells and the blood-brain barrier.
Article
Cell & Tissue Engineering
Alexander Bell, Ashalyn P. Watt, Ingrid Dudink, Yen Pham, Amy E. Sutherland, Beth J. Allison, Courtney A. McDonald, Margie Castillo-Melendez, Graham Jenkin, Atul Malhotra, Suzanne L. Miller, Tamara Yawno
Summary: This study found that administration of endothelial colony forming cells (ECFC) from human umbilical cord blood improved the development of the neurovascular unit (NVU) in both normally developing and growth-restricted fetal sheep. It increased vascular density, astrocyte coverage, and VEGF expression in the fetal brain.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Haoan Wu, Bin Peng, Farrah S. Mohammed, Xingchun Gao, Zhenpeng Qin, Kevin N. Sheth, Jiangbing Zhou, Zhaozhong Jiang
Summary: This article reports the development of multifunctional polymeric nanoparticles for stroke treatment and drug delivery. The nanoparticles can penetrate ischemic brain tissue efficiently and exhibit excellent antioxidant activity. The study demonstrates the efficacy of the nanoparticles in delivering therapeutic agents for stroke treatment.
Article
Biochemistry & Molecular Biology
Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang
Summary: Blood-brain barrier (BBB) breakdown is a common feature of ischemic stroke. This study reveals that overexpression of mitochondrial ferritin (FtMt) can attenuate BBB disruption in an ischemia-reperfusion (I/R) injury model by inhibiting iron dysregulation and reactive oxygen species accumulation. These findings provide novel insights into the protective role of FtMt in maintaining BBB integrity during ischemic stroke.
Article
Neurosciences
Yanzhao Zhou, Feng Yan, Xue Han, Xin Huang, Xiang Cheng, Yanan Geng, Xiufang Jiang, Ying Han, Ming Zhao, Lingling Zhu
Summary: NB-3 plays an important role in neural development and injury recovery. It maintains the integrity of the blood brain barrier under high-altitude cerebral edema conditions. Deficiency of NB-3 leads to BBB leakage and downregulation of tight junction proteins, while overexpression or supplementation with NB-3 can alleviate endothelial barrier injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Immunology
Yan-mei Qiu, Chun-lin Zhang, An-qi Chen, Hai-ling Wang, Yi-fan Zhou, Ya-nan Li, Bo Hu
Summary: Blood-Brain Barrier (BBB) disruption is a crucial pathophysiological process in acute ischemic stroke, where the rapid activation of immune cells plays a critical role. Infiltrating immune cells increase BBB permeability, causing microvascular disorder, but also promote BBB repair and angiogenesis. Understanding the inflammatory mechanisms behind BBB disruption can lead to the development of more effective therapeutics for acute ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jinghuan Wang, Wen Zhong, Qianwen Cheng, Chenxi Xiao, Jie Xu, Zhenghua Su, Haibi Su, Xinhua Liu
Summary: Smyd2 plays a vital role in disrupting blood-brain barrier integrity in ischaemic stroke through methylation-mediated Sphk/S1PR, and knocking down Smyd2 reduces blood-brain barrier permeability and improves functional recovery.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Reed Berlet, Stefan Anthony, Beverly Brooks, Zhen-Jie Wang, Nadia Sadanandan, Alex Shear, Blaise Cozene, Bella Gonzales-Portillo, Blake Parsons, Felipe Esparza Salazar, Alma R. Lezama Toledo, German Rivera Monroy, Joaquin Vega Gonzales-Portillo, Cesario Borlongan
Summary: Combining stem cell transplantation with rehabilitation therapy presents a promising approach in treating stroke, with potential for better functional outcomes for patients. This comprehensive review assesses the advantages and disadvantages of using this combined therapy to mitigate the devastating effects of stroke.
Review
Biochemistry & Molecular Biology
Kazufumi Ohmura, Hiroyuki Tomita, Akira Hara
Summary: Treating malignant glioma, which can invade healthy brain tissue and cause intense surrounding edema, is challenging. Steroid therapy has been the standard treatment for peritumoral edema, but the discovery of cerebral lymphatic vessels has prompted a re-evaluation of the mechanisms involved. This review summarizes the known mechanisms of glioma-related edema, discusses the limitations in current therapies, and presents prospects for future cerebral edema treatments. Further research is needed to enhance patient prognosis and treatment efficacy.
Article
Cardiac & Cardiovascular Systems
Kshitij Mohan, Gilles Gasparoni, Abdulrahman Salhab, Michael M. Orlich, Robert Geffers, Steve Hoffmann, Ralf H. Adams, Joern Walter, Alfred Nordheim
Summary: The study examined the increased incidence of intracerebral bleeding and age-related changes in gene expression in cerebral endothelial cells of aged mice, revealing alterations in genes involved in blood-brain barrier and vascular integrity maintenance. Age-dependent downregulation of the Aplnr gene and reduced chromatin accessibility of its promoter region in cerebral endothelial cells suggest a critical role of the apelinergic axis in maintaining blood-brain barrier and vascular integrity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Yanyan He, Lin Duan, Haigang Wu, Song Chen, Taoyuan Lu, Tianxiao Li, Yingkun He
Summary: The study demonstrated that photodynamic intervention has dosage-dependent effects on cerebrovascular endothelial cells, affecting the expression levels of transporter-related genes and potentially inducing disorder of intracellular organelles. Furthermore, it suggested that PDT may have drawbacks on cerebrovascular functions by altering gene expression levels related to cellular transport.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Rais Reskiawan A. Kadir, Ulvi Bayraktutan
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2020)
Review
Cell Biology
Rais Reskiawan A. Kadir, Mansour Alwjwaj, Ulvi Bayraktutan
Summary: Stroke is the third-leading cause of death and disability worldwide, and the limited availability of diagnostic tools, therapeutics, and biomarkers remains a major challenge. Recent research has discovered the potential of miRNAs, non-coding RNAs that regulate gene expression, as reliable blood-based markers for predicting, diagnosing, and prognosing ischemic stroke. Additionally, miRNA treatments have shown potential neuroprotective effects in animal models of ischemic stroke. However, further research is needed to determine the optimal treatment timing and route of administration.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Rais Reskiawan A. Kadir, Mansour Alwjwaj, Zoe McCarthy, Ulvi Bayraktutan
Summary: Therapeutic hypothermia enhances the protective effects of PKC-beta or Nox2 inhibition on BBB integrity and function in the setting of hyperglycaemia. Combining PKC-beta or Nox2 inhibition with therapeutic hypothermia is more effective in repairing physical damage, decreasing Nox activity and superoxide anion production, and suppressing actin stress fibre formation compared to using either agent alone. Additionally, the combinatory approach is more effective in maintaining normal cytoskeletal structure.
METABOLIC BRAIN DISEASE
(2021)
Article
Neurosciences
Mansour Alwjwaj, Rais Reskiawan A. Kadir, Ulvi Bayraktutan
Summary: OECs show potential for repairing BBB integrity and function following ischemic damage, with greater resistance to oxidative stress compared to HBMECs. Targeting NOX2 to suppress oxidative stress may help restore BBB integrity and function, but caution is needed when using OECs as therapeutics.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Rais Reskiawan A. Kadir, Mansour Alwjwaj, Ulvi Bayraktutan
Summary: This study comparatively assessed the effect of PKC-beta inhibitor LY333531 on the cerebral barrier integrity formed by OECs or HBMECs. The results showed that LY333531 protected the barrier formed by HBMECs and exacerbated the damage in OECs. Furthermore, a lower concentration of LY333531 (0.01μM) had a smaller impact on the damage.
METABOLIC BRAIN DISEASE
(2022)
Article
Multidisciplinary Sciences
Andi Alfian Zainuddin, Amran Rahim, Sri Ramadany, Himawan Dharmayani, Hedi Kuswanto, Rais Reskiawan A. Kadir, Andi Afdal Abdullah, Haerani Rasyid
Summary: The spatial variation and potential linkage of type 2 diabetes and hypertension were explored in South Sulawesi Province, Indonesia. Global Moran's I and regression analysis were used to identify the characteristics involved. The analysis was based on data from 2017 and 2018 acquired from Social Health Insurance Administration in Indonesia. The findings showed that type 2 diabetes and hypertension have a random spatial distribution, and there is a significant relationship between the two conditions.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Rais Reskiawan A. Kadir, Mansour Alwjwaj, Kamini Rakkar, Othman Ahmad Othman, Nikola Sprigg, Philip M. Bath, Ulvi Bayraktutan
Summary: Improved understanding of the mechanisms underlying cerebral ischemic injury is crucial for developing effective therapeutics for stroke. This study found significant elevations in TNF-alpha levels in plasma samples from ischemic stroke patients at different time points after stroke. The inflammatory cytokine was found to impair blood-brain barrier integrity and function, leading to early death. However, co-treatment with outgrowth endothelial cell-derived conditioned media (OEC-CM) mitigated the detrimental effects of TNF-alpha on the blood-brain barrier. OEC-CM showed vasculoprotective effects by suppressing anti-angiogenic factors, reducing oxidative stress and apoptosis, and improving the adhesive and tubulogenic properties of brain microvascular endothelial cells and OECs.
STEM CELL REVIEWS AND REPORTS
(2023)
Review
Cell Biology
Mansour Alwjwaj, Rais Reskiawan A. Kadir, Ulvi Bayraktutan
Summary: Ischemic stroke remains a significant cause of mortality and morbidity worldwide. While thrombolysis with recombinant tissue plasminogen activator is the primary pharmacological therapy, its narrow therapeutic window limits its application to less than 1% of stroke patients globally each year. Endothelial progenitor cells (EPCs) have potential as a therapeutic beyond the acute phase of stroke, but their limited availability and early senescence in culture conditions hinder their efficacy.
NEURAL REGENERATION RESEARCH
(2021)
Article
Cell Biology
Rais Reskiawan Abdulkadir, Mansour Alwjwaj, Othman Ahmad Othman, Kamini Rakkar, Ulvi Bayraktutan
NEURAL REGENERATION RESEARCH
(2020)