Inborn errors of IKAROS and AIOLOS

The Ever-Increasing Array of Novel Inborn Errors of Immunity: an Interim Update by the IUIS Committee

(2021) Stuart G. Tangye et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice

(2021) Brigette Boast et al.   JOURNAL OF IMMUNOLOGY

Abnormal SCID Newborn Screening and Spontaneous Recovery Associated with a Novel Haploinsufficiency IKZF1 Mutation

(2021) Hye Sun Kuehn et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS

(2021) Motoi Yamashita et al.   NATURE IMMUNOLOGY

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

(2020) Stuart G. Tangye et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Whole-Exome Sequencing-Based Approach for Germline Mutations in Patients with Inborn Errors of Immunity

(2020) Tsubasa Okano et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Germline IKAROS dimerization haploinsufficiency causes hematologic cytopenias and malignancies

(2020) Hye Sun Kuehn et al.   BLOOD

Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells

(2019) Carolina Lyon de Ana et al.   JOURNAL OF IMMUNOLOGY

Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genes

(2019) Jérôme Hadjadj et al.   BLOOD

Allogeneic hematopoietic stem cell transplant outcomes for patients with dominant negative IKZF1/IKAROS mutations

(2019) Erinn S. Kellner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IKZF1 Loss-of-Function Variant Causes Autoimmunity and Severe Familial Antiphospholipid Syndrome

(2019) Yannick Dieudonné et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Familial Immune Thrombocytopenia Associated With a Novel Variant in IKZF1

(2019) Panida Sriaroon et al.   Frontiers in Pediatrics

Germline mutations in the transcription factor IKZF5 cause thrombocytopenia

(2019) Claire Lentaigne et al.   BLOOD

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

(2019) Zoya Eskandarian et al.   Frontiers in Immunology

Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

(2018) Michelle L. Churchman et al.   CANCER CELL

The Ikaros family in lymphocyte development

(2018) Beate Heizmann et al.   CURRENT OPINION IN IMMUNOLOGY

A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects

(2018) Delfien J. Bogaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A kindred with mutant IKAROS and autoimmunity

(2018) Erika Van Nieuwenhove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency

(2018) David Boutboul et al.   JOURNAL OF CLINICAL INVESTIGATION

B-cell Deficiency: A De Novo IKZF1 Patient and Review of the Literature

(2018) QY Chen et al.   JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY

The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma

(2017) Katia Georgopoulos   GENES & DEVELOPMENT

Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations

(2017) Akihiro Hoshino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia

(2017) N Yoshida et al.   LEUKEMIA

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

(2016) Yeguang Hu et al.   GENES & DEVELOPMENT

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients

(2016) Blanca Scheijen et al.   HAEMATOLOGICA

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway

(2016) Shiyang Li et al.   IMMUNITY

Loss of B Cells in Patients with Heterozygous Mutations in IKAROS

(2016) Hye Sun Kuehn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients

(2016) Blanca Scheijen et al.   HAEMATOLOGICA

Genetic Diagnosis Using Whole Exome Sequencing in Common Variable Immunodeficiency

(2016) Patrick Maffucci et al.   Frontiers in Immunology

Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2

(2015) Attila Oravecz et al.   Nature Communications

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

(2014) Stefania Bottardi et al.   PLoS Genetics

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

(2013) Hilde Schjerven et al.   NATURE IMMUNOLOGY

Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene

(2011) Frederick D. Goldman et al.   PEDIATRIC BLOOD & CANCER

Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis

(2010) Pablo Gómez-del Arco et al.   IMMUNITY

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

(2009) Samuel Yao-Ming Ng et al.   IMMUNITY

IKZF1(Ikaros) Deletions inBCR-ABL1–Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report

(2009) Giovanni Martinelli et al.   JOURNAL OF CLINICAL ONCOLOGY

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

(2009) Charles G. Mullighan et al.   NEW ENGLAND JOURNAL OF MEDICINE

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE