Direct visualization and profiling of protein misfolding and aggregation in live cells

A Luminescence-Based System for Identification of Genetically Encodable Inhibitors of Protein Aggregation

(2020) Travis J. Nelson et al.   ACS Omega

A General Strategy to Control Viscosity Sensitivity of Molecular Rotor‐Based Fluorophores

(2020) Songtao Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AggFluor: Fluorogenic Toolbox Enables Direct Visualization of the Multi-Step Protein Aggregation Process in Live Cells

(2020) Charles H. Wolstenholme et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monitoring the Dynamics of Proteome Aggregation in Live Cells Using a Solubilized and Noncovalent Analogue of Fluorescent Protein Chromophores

(2020) Wang Wan et al.   ANALYTICAL CHEMISTRY

A fluorogenic AggTag method based on Halo- and SNAP-tag to simultaneously detect aggregation of two proteins in live cells

(2019) Kwan Ho Jung et al.   CHEMBIOCHEM

A Maleimide‐functionalized Tetraphenylethene for Measuring and Imaging Unfolded Proteins in Cells

(2019) Shouxiang Zhang et al.   Chemistry-An Asian Journal

Real‐time BODIPY‐binding assay to screen inhibitors of the early oligomerization process of Aβ 1‐42 peptide

(2019) Nicolo Tonali et al.   CHEMBIOCHEM

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

(2019) Tze Cin Owyong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A HaloTag-Based Multicolor Fluorogenic Sensor Visualizes and Quantifies Proteome Stress in Live Cells Using Solvatochromic and Molecular Rotor-Based Fluorophores

(2018) Yu Liu et al.   BIOCHEMISTRY

A Molecular Rotor-Based Halo-Tag Ligand Enables a Fluorogenic Proteome Stress Sensor to Detect Protein Misfolding in Mildly Stressed Proteome

(2018) Matthew Fares et al.   BIOCONJUGATE CHEMISTRY

Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer

(2018) He Meng et al.   JOURNAL OF PROTEOME RESEARCH

Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence

(2018) Yu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A biosensor-based framework to measure latent proteostasis capacity

(2018) Rebecca J. Wood et al.   Nature Communications

In-Cell Titration of Small Solutes Controls Protein Stability and Aggregation

(2018) Shahar Sukenik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability

(2017) Pascal Leuenberger et al.   SCIENCE

A thiol probe for measuring unfolded protein load and proteostasis in cells

(2017) Moore Z. Chen et al.   Nature Communications

Cellular proteostasis: degradation of misfolded proteins by lysosomes

(2016) M. P. Jackson et al.   Essays in Biochemistry

Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis

(2016) Fang Liu et al.   JOURNAL OF PROTEOME RESEARCH

Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells

(2016) Jia Zhao et al.   Molecular BioSystems

Rationalizing fluorescence quenching in meso-BODIPY dyes

(2016) Antonio Prlj et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Distinct stress conditions result in aggregation of proteins with similar properties

(2016) Alan J. Weids et al.   Scientific Reports

Self-Assembling NanoLuc Luciferase Fragments as Probes for Protein Aggregation in Living Cells

(2015) Jia Zhao et al.   ACS Chemical Biology

Aggregation-Induced Emission: Together We Shine, United We Soar!

(2015) Ju Mei et al.   CHEMICAL REVIEWS

Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation

(2015) Alexander J. Thompson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Global Analysis of Protein Folding Thermodynamics for Disease State Characterization

(2015) Jagat Adhikari et al.   JOURNAL OF PROTEOME RESEARCH

Energetics-Based Methods for Protein Folding and Stability Measurements

(2014) M. Ariel Geer et al.   Annual Review of Analytical Chemistry

Global analysis of protein structural changes in complex proteomes

(2014) Yuehan Feng et al.   NATURE BIOTECHNOLOGY

FTIR spectroscopic imaging of protein aggregation in living cells

(2013) Lisa M. Miller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Differential scanning fluorescence approach using a fluorescent molecular rotor to detect thermostability of proteins in surfactant-containing formulations

(2012) Elisabeth Ablinger et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Split-protein systems: beyond binary protein–protein interactions

(2011) Sujan S Shekhawat et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Monitoring and Inhibition of Insulin Fibrillation by a Small Organic Fluorogen with Aggregation-Induced Emission Characteristics

(2011) Yuning Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives

(2011) Seung-Jae Lee et al.   NEUROSCIENCE RESEARCH

Factors Defining Effects of Macromolecular Crowding on Protein Stability: An in Vitro/in Silico Case Study Using Cytochromec

(2010) Alexander Christiansen et al.   BIOCHEMISTRY

Protein folding stability and dynamics imaged in a living cell

(2010) Simon Ebbinghaus et al.   NATURE METHODS

Monitoring protein interactions and dynamics with solvatochromic fluorophores

(2009) Galen S. Loving et al.   TRENDS IN BIOTECHNOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE