Intravital microscopy to illuminate cell state plasticity during metastasis

Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

(2021) Takahisa Maruno et al.   eLife

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

(2021) Erik Jung et al.   Nature Communications

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

(2020) Arianna Fumagalli et al.   Cell Stem Cell

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis

(2020) Yan Li et al.   DEVELOPMENTAL CELL

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

(2020) Olga Ilina et al.   NATURE CELL BIOLOGY

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

(2019) Maartje van der Heijden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Hierarchical Regulatory Landscape during the Multiple Stages of EMT

(2019) Nathalie Meyer-Schaller et al.   DEVELOPMENTAL CELL

Cellular Plasticity in Cancer

(2019) Salina Yuan et al.   Cancer Discovery

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

The great escape: tumour cell plasticity in resistance to targeted therapy

(2019) Soufiane Boumahdi et al.   NATURE REVIEWS DRUG DISCOVERY

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

(2019) Claire Vennin et al.   Nature Communications

Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT

(2019) Laura Bornes et al.   Cell Reports

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

(2018) Shiro Yui et al.   Cell Stem Cell

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

(2018) Sander C Steenbeek et al.   EMBO JOURNAL

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

(2018) Ysbrand M. Nusse et al.   NATURE

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

(2018) Kristiaan J. Lenos et al.   NATURE CELL BIOLOGY

The bone microenvironment promotes tumor growth and tissue perfusion compared with striated muscle in a preclinical model of prostate cancer in vivo

(2018) Haider Mussawy et al.   BMC CANCER

Cellular Plasticity in Intestinal Homeostasis and Disease

(2018) Felipe de Sousa e Melo et al.   Cell Stem Cell

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition

(2018) Brian Biehs et al.   NATURE

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Visualization and targeting of LGR5+ human colon cancer stem cells

(2017) Mariko Shimokawa et al.   NATURE

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

A permanent window for the murine lung enables high-resolution imaging of cancer metastasis

(2017) David Entenberg et al.   NATURE METHODS

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

(2017) Arianna Fumagalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance

(2017) Yapeng Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism

(2017) George S. Karagiannis et al.   Science Translational Medicine

Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer

(2017) Sebastian Lamprecht et al.   Nature Communications

In Vivo Visualization and Characterization of Epithelial–Mesenchymal Transition in Breast Tumors

(2016) Zhen Zhao et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Intra-tumour heterogeneity - going beyond genetics

(2016) Francisco Caiado et al.   FEBS Journal

Defining the clonal dynamics leading to mouse skin tumour initiation

(2016) Adriana Sánchez-Danés et al.   NATURE

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases

(2015) Han-Sin Jeong et al.   JNCI-Journal of the National Cancer Institute

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

(2015) Bartlomiej Waclaw et al.   NATURE

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases

(2015) Han-Sin Jeong et al.   JNCI-Journal of the National Cancer Institute

Multiparametric Classification Links Tumor Microenvironments with Tumor Cell Phenotype

(2014) Bojana Gligorijevic et al.   PLOS BIOLOGY

Continuous Clonal Labeling Reveals Small Numbers of Functional Stem Cells in Intestinal Crypts and Adenomas

(2013) Sarah Kozar et al.   Cell Stem Cell

Surgical implantation of an abdominal imaging window for intravital microscopy

(2013) Laila Ritsma et al.   Nature Protocols

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Brief Report: Intravital Imaging of Cancer Stem Cell Plasticity in Mammary Tumors

(2012) Anoek Zomer et al.   STEM CELLS

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Intravital imaging of metastatic behavior through a mammary imaging window

(2008) Dmitriy Kedrin et al.   NATURE METHODS