Article
Chemistry, Analytical
Hong-Hong Rao, Hai-Xia Liu, Ming-Yue Luo, Xin Xue, Ming-Ming Wei, Zhong-Hua Xue
Summary: Point-of-care testing (POCT) technology is a convenient, fast and online analysis technology widely used in disease diagnosis, health management, and other fields. The introduction of nanozymes and functionalized nanomaterials accelerates the application of simple analysis signal readout, promoting the development of POCT methods based on simple readout.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yi Hou, Shuai Yuan, Guangda Zhu, Baihao You, Ying Xu, Wenxin Jiang, Ho Cheung Shum, Philip W. T. Pong, Chia-Hung Chen, Liqiu Wang
Summary: In this study, a 3D composite photonic crystal (PC)-based optoelectronic device is designed for fast, naked-eye, high-resolution ultratrace detection. The mechanically strong ellipsoidal composite PCs are hand-machined into rectangular geometries, allowing them to be easily integrated with the flat light-detection area. The developed PC-based device shows improved signal-to-noise ratio, enabling rapid identification of ultratrace analytes and detection of glucose in artificial sweat.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Shan Jiang, Lvxia Zhang, Jizhou Li, Hui Ouyang, Zhifeng Fu
Summary: A sensitive immunochromatographic test strip (ITS) for detecting AFB(1) using dendritic platinum nanoparticles as pressure/colorimetric dual-readout probes was developed. The ITS showed a detection range of 0.05-10 ng mL(-1) with a detection limit of 0.03 ng mL(-1) for AFB(1). It was successfully utilized for detecting AFB(1) in herbal medicine samples, demonstrating its reliability for real sample detection and potential applications in drug and food quality control, pollutants monitoring, and medical diagnosis.
Review
Chemistry, Analytical
Jongwon Park
Summary: Due to the recent pandemic, lateral flow immunoassays have become popular for rapid antigen tests, especially for COVID-19. However, there is an increasing demand for quantitative analysis in various fields. Quantitative analysis readers are being developed using different materials and sensor technologies, and advancements such as optical, magnetic field, photothermal, and electrochemical sensors are being utilized. The sensing, processing, and communication functions of portable devices like smartphones can also be used for quantitative analysis. The article provides a classification and review of the research trends in quantitative analysis readers, as well as the development of assay methods and COVID-19 quantitative analysis systems.
Article
Engineering, Environmental
Yanjie Chen, Jie Wei, Shupei Zhang, Hong Dai, Liang Lv, Yanyu Lin
Summary: In this study, a photothermal triggered multi-signal point-of-care testing protocol was developed for the determination of Human papillomavirus type 16 E6 protein in clinical vagina swabs. The protocol integrated a portable vagina swab as a sensing substrate, a composite probe SiC-CS@Ag as a label, and a flexible fluorescence-temperature indicator (FLTI) with thermal-responsive fluorescence capability. The system achieved sensitive target detection and provided rapid and precise methodologies for biomarker detection, presenting potential for early diagnosis of malignant diseases in remote areas.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Tong Li, Nan Cheng
Summary: This review article focuses on the signal readout and sensitivity-improving strategies of CRISPR/Cas12a biosensors, and introduces innovative applications of portability strategies.
Article
Biophysics
Lin Li, Hui Tian, Guofu Wang, Suyue Ren, Tinglei Ma, Yixiang Wang, Shenguang Ge, Yan Zhang, Jinghua Yu
Summary: Ready-to-use in vitro diagnosis is crucial for cervical cancer prevention and treatment. A paper-film-based differential lateral flow biosensor is proposed, allowing simultaneous detection of two high-risk HPV types. The biosensor utilizes a CuCo2S4/ZnIn2S4 heterostructure on a paper-film chip and introduces surface sulfur vacancy for enhanced photoexcitation. Through sequential solution transfer, the biosensor activates the self-assembly of DNA and the cleavage activity of CRISPR-Cas12a, resulting in the release of polydopamine-coated gold nanoparticles. This intelligent biosensor achieves low limit-of-detection for HPV-18 and HPV-16 and provides a promising approach for home medical intelligent diagnosis.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Jinzhu Ma, Lili Ma, Lili Cao, Yuming Miao, Jiangxue Dong, Yu-e Shi, Zhenguang Wang
Summary: The study introduces a portable photothermal assay for the rapid detection of Butyrylcholinesterase (BChE) activity, which enhances the formation efficiency of Cu9S8 nanoparticles by modulating the efficacy of nanoparticles through the photothermal effects. The method demonstrates a strong linear relationship between the concentration of BChE and temperature change.
Article
Chemistry, Analytical
Mengmeng Chen, Yu Wang, Xudong Zhao, Jingyang Zhang, Yuan Peng, Jialei Bai, Shuang Li, Dianpeng Han, Shuyue Ren, Kang Qin, Sen Li, Tie Han, Zhixian Gao
Summary: A portable visual quantitative assay for CK-MB was developed by combining target-responsive DNA hydrogel and a microfluidic chip. This method has the potential for quantitative point-of-care testing in resource-constrained settings.
Article
Chemistry, Analytical
Lingzhi Fan, Jing Yang, Jianbing Wu, Fugang Li, Wannian Yan, Fei Tan, Madeline Zhang, Mohamed S. Draz, Huanxing Han, Pengfei Zhang
Summary: A new deeply dyed nanobead (DDNB) system was developed for the sensitive detection of trace drugs in hair samples. The DDNB strips showed significantly higher sensitivity compared to traditional gold nanoparticle-based immunoassays, allowing for the detection of drugs such as morphine and methamphetamine within minutes.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Yixiang Wang, Yumeng Rong, Tinglei Ma, Lin Li, Xu Li, Peihua Zhu, Shuang Zhou, Jinghua Yu, Yan Zhang
Summary: This review systematically discusses the design and fabrication of portable paper-based photoelectrochemical (PEC) sensors for point-of-care testing (POCT). It covers the flexible electronic devices made from paper, photosensitive materials, signal amplification strategies, and applications in medical diagnosis, environmental monitoring, and food safety. The opportunities and challenges of paper-based PEC sensing platforms are also summarized.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Conghui Jia, Shaochi Wang, Sijie Liu, Yuechun Li, Xianghong Xie, Huilan Hu, Jing Ren, Yanli Tian, Jing Sun, Daohong Zhang, Mingqiang Zhu, Jianlong Wang, Yining He
Summary: This study developed a novel label for immunochromatographic test strips (ITS) that enables quantitative analysis using colorimetric and photothermal signals for clenbuterol monitoring. By loading tannic acid (TA)-assisted stripping WS2 nanosheets (TA-WS2 NSs), the sensitivity of the test strips was significantly improved. This research also provides a reference method for detecting other small molecule pollutants.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Maria Lopez-Valls, Carmen Escalona-Noguero, Ciro Rodriguez-Diaz, Demian Pardo, Milagros Castellanos, Paula Milan-Rois, Carlos Martinez-Garay, Rocio Coloma, Melanie Abreu, Rafael Canton, Juan Carlos Galan, Rodolfo Miranda, Alvaro Somoza, Begona Sot
Summary: The COVID-19 pandemic highlights the necessity of fast and sensitive detection methods to prevent pathogen spread. In this study, the authors present CASCADE, a sensing system that allows rapid naked-eye detection of SARS-CoV-2 RNA. CASCADE utilizes LwaCas13a CRISPR protein and gold nanoparticles to recognize and visualize target RNA.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Xinghui Yu, Yongqiang Ma, Siyuan Liu, Chunchun Qi, Weiqi Zhang, Wen Xiang, Zhaoxian Li, Kai Yang, Shaoxian Duan, Xinrao Du, Jian Yu, Yan Xie, Zicheng Wang, Wentao Jiang, Li Zhang, Xiaodong Lin
Summary: Post-operative pathogenic infections in liver transplantation pose a serious threat to human health. Researchers have developed a chemiluminescence-based method for the rapid and sensitive detection of Staphylococcus aureus. By integrating specific capture and separation techniques, this portable device, integrated with a smartphone, enables specific detection of S. aureus with high antibacterial efficiency. The method is simple to use and cost-effective, demonstrating great potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biophysics
Juan Tang, Liping Liu, Jiao Qin, Xiaoting Lv, Jinjin Li, Dianping Tang, Junyang Zhuang
Summary: A dual-readout assay method for miRNA detection based on BMMPT and CHA strategies was demonstrated, achieving high sensitivity and accuracy for miRNA-21. The use of PB@MOF-Fe2+ enabled detection of miRNA-21 at concentrations as low as 0.3 fM and 0.32 fM using temperature readout or electrochemical readout, respectively.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)