Article
Clinical Neurology
Akiyoshi Matsugi, Tomoyuki Shiozaki, Hiroaki Tanaka
Summary: The study investigated the effects of noisy galvanic vestibular stimulation (nGVS) on the vestibulo-ocular reflex (VOR) and body sway. Results showed that nGVS at 0.2 mA inhibited the VOR, while nGVS at 0.6 mA increased body sway during upright standing. However, there may not be a significant relationship between these effects in healthy individuals.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Isaura Rodriguez Montesdeoca, Angel Ramos de Miguel, Juan Carlos Falcon Gonzalez, Silvia Borkoski Barreiro, Nicolas Perez Fernandez, Robby Vanspauwen, Angel Ramos-Macias
Summary: The study analyzed vestibular-evoked myogenic potentials (VEMPs) obtained from patients implanted with cochlear and vestibulo-cochlear implants, showing that electrically evoked cVEMPs can be present after cochlear and vestibular stimulation, suggesting stimulation of vestibular elements which warrants further clinical study.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Bernardo Faria Ramos, Renato Cal, Sergio Carmona, Konrad P. Weber, Francisco Zuma e Maia
Summary: The VVOR and VORS tests can be used to evaluate eye movements in patients with vestibular hypofunction, with unilateral patients exhibiting corrective eye movements towards the healthy side, while bilateral patients do not exhibit corrective eye movements.
Article
Clinical Neurology
Priyani Patel, Patricia Castro, Nehzat Koohi, Qadeer Arshad, Lucia Gargallo, Sergio Carmona, Diego Kaski
Summary: This study explores whether the vestibulo-ocular reflex (VOR) gain changes in response to a clinical headshake maneuver in patients with vestibular migraine (VM). The study found that there was no significant change in VOR gain after headshaking in any group. Patients who reported nausea when reading in the passenger seat of a car were more likely to have VM.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Hyun Sung Kim, Eun Hye Oh, Jeong-Yeon Kim, Seo Young Choi, Kwang-Dong Choi, Jae-Hwan Choi
Summary: This study investigated the incidence, pattern, and etiology of dissociated vestibulo-ocular reflex (VOR) function in dizzy patients. It found that discordant VOR function according to the stimulus frequency was not uncommon and different etiologies showed specific patterns of VOR dissociation.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ning Ma, Handi Liu, Bing Liu, Li Zhang, Bei Li, Yang Yang, Wei Liu, Min Chen, Jianbo Shao, Xiao Zhang, Xin Ni, Jie Zhang
Summary: This study aimed to evaluate the effectiveness and acceptance of Vestibulo-Ocular Reflex (VOR) adaptation training in children with recurrent vertigo. The results showed that VOR adaptation training can effectively improve vertigo symptoms and is more accepted by children compared to classic Cawthorne-Cooksey training.
FRONTIERS IN NEUROLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Dmitrii Starkov, Maksim Pleshkov, Nils Guinand, Angelica Perez Fornos, Maurizio Ranieri, Samuel Cavuscens, Joost Johannes Antonius Stultiens, Elke Maria Johanna Devocht, Herman Kingma, Raymond van de Berg
Summary: This study investigates the impact of different eye movement analysis algorithms on the analysis of electrically evoked vestibulo-ocular reflex (eVOR) in vestibular implant research. The results indicate that the type of analysis algorithm significantly influences eVOR outcomes, particularly the VOR gain and asymmetry in patients with bilateral vestibulopathy.
AUDIOLOGY AND NEURO-OTOLOGY
(2022)
Article
Clinical Neurology
Jacob M. Pogson, Rachael L. Taylor, Andrew P. Bradshaw, Leigh McGarvie, Mario D'Souza, Sean Flanagan, Jonathan Kong, Nigel Biggs, Brindha Shivalingam, Simon Greenberg, Glen Croxson, G. Michael Halmagyi, Miriam S. Welgampola
Summary: The vestibulo-ocular reflex (VOR) and compensatory-saccades undergo changes after surgical unilateral vestibular deafferentation (UVD). Compensatory-saccades adapt within one week post-surgery and remain stable over one year.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Jennifer Wing Yee Lee, Fatemeh Hassannia, John Alexander Rutka
Summary: The study investigated the impact of unilateral vestibular schwannoma on VOR function, finding both ipsilesional and contralesional VOR impairment in patients, with bilateral VOR impairment correlating with tumor size. Brainstem compression was associated with reduced ipsilesional VOR gain, but not contralesional VOR gain.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Clinical Neurology
Carlo N. Rinaudo, Michael C. Schubert, Phillip D. Cremer, William V. C. Figtree, Christopher J. Todd, Americo A. Migliaccio
Summary: Incremental VOR training shows significant improvement in VOR gain, balance during gait with head rotation, and symptoms in patients with chronic peripheral vestibular hypofunction. This training method may be more effective than conventional x1 gaze-stabilizing exercises.
JOURNAL OF NEUROLOGIC PHYSICAL THERAPY
(2021)
Article
Clinical Neurology
Gi-Sung Nam, Thanh Tin Nguyen, Jin-Ju Kang, Gyu Cheol Han, Sun-Young Oh
Summary: The study investigated the effects of sinusoidal galvanic vestibular stimulation (GVS) on vestibular compensation in a mouse model of unilateral labyrinthectomy (UL). Results showed that GVS intervention accelerated recovery of locomotion and vestibulo-ocular reflex (VOR) deficits induced by unilateral vestibular deafferentation (UVD). This suggests that GVS has the potential to improve vestibular compensation in patients with acute unilateral vestibular failure.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Deniz Ugur Cengiz, Hatice Seyra Erbek, Sanem Can Colak, Buesra Kurtcu, Suemeyye Demirel Birisik, Ercan Karababa, Busra Kusman, Emre Akguen Ozdemir, Mehmet Isik, Ismail Demir
Summary: This study aimed to determine the normative values of the functional head impulse test (fHIT) in healthy young adults. The results showed differences in fHIT values between different semicircular canals and genders, providing important data for future studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Susan King, Kilian Dahlem, Faisal Karmali, Konstantina M. Stankovic, D. Bradley Welling, Richard F. Lewis
Summary: The severity of symptoms associated with vestibular schwannomas (VS) is poorly correlated with standard vestibulo-ocular reflex (VOR) metrics that are based on response amplitude. Imbalance in patients with VS scales with VOR precision and time constant, but not with VOR accuracy. Dizziness is related to the presence of a static central tone imbalance but not to any VOR metrics.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Serajul Khan, Alan M. Brichta, Americo A. Migliaccio
Summary: This study investigated the effect of ascorbate on the recovery of vestibulo-ocular reflex (VOR) after labyrinthectomy. The results showed that treatment with ascorbate reduced acute loss and aided in the recovery during the acute to chronic compensation stages. One possible mechanism is that ascorbate enhances the vestibulo-ocular reflex pathway, increasing the number and sensitivity of vestibular afferents.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2022)
Article
Clinical Neurology
Darrian Rice, Giorgio P. Martinelli, Weitao Jiang, Gay R. Holstein, Suhrud M. Rajguru
Summary: This study demonstrates that activation of a single vertical semicircular canal is sufficient to modulate central pathways controlling heart rate and blood pressure. Both IR and electrical current stimulation led to similar effects on heart rate variability, altering the LF/HF ratio which estimates the relative contributions of sympathetic and parasympathetic nervous system activities. Atropine and propranolol injections confirmed the involvement of cholinergic and adrenergic pathways in the observed responses.
FRONTIERS IN NEUROLOGY
(2021)
Article
Engineering, Electrical & Electronic
P. Julian, A. G. Andreou, M. Villemur, N. Rodriguez
Summary: This paper proposes a method using the simplicial algorithm to compute digital vector-vector multiplication without multiplications, showing improved error propagation during parameter quantization and more efficient digital implementation in the case of large number of inputs. The method also has the capability to produce multivariable nonlinear processing.
INTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS
(2021)
Article
Engineering, Electrical & Electronic
Christos Sapsanis, Marios Sophocleous, Andreas G. Andreou, Julius Georgiou
Summary: This tutorial discusses trade-offs in sensor system design, addressing design considerations at different system levels and introducing fundamental concepts and practical considerations for sensor readout systems. The tutorial explores both fundamental trade-offs and practical/technological trade-offs, providing important insights towards the design of sensory systems operating within demanding constraints.
IEEE SENSORS JOURNAL
(2022)
Article
Health Care Sciences & Services
Molly J. E. Snider, Daniel Lee, Bryce Chiang, Sunil Gupta, Yousuf Khalifa, April Y. Maa
Summary: This study compared the rates and severity of diabetic eye disease detected by teleophthalmology between safety net and non-Safety Net Hospitals. The results showed that participants at Safety Net Hospitals had higher rates of eye disease and severity compared to those at non-Safety Net Hospitals. Teleophthalmology remains an important tool in reducing health inequalities and addressing barriers faced by underserved communities.
TELEMEDICINE AND E-HEALTH
(2022)
Article
Ophthalmology
Bryce Chiang, Gabriel S. Valerio, Edward E. Manche
Summary: The study compared the visual outcomes of WFG-LASIK and SMILE in treating myopic patients. The results showed that at 12 months, WFG-LASIK eyes had faster visual recovery, better low-contrast visual acuity, and greater gains in uncorrected visual acuity compared to SMILE eyes.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Bryce Chiang, Edward E. Manche
Summary: The purpose of this study was to compare the subjective visual experience and ocular symptoms of fellow eyes treated with wavefront-optimized laser-assisted in situ keratomileusis (WFO-LASIK) and wavefront-guided laser-assisted in situ keratomileusis (WFG-LASIK). The majority of subjects had no eye preference, and for subjects who did have eye preference, the only detectable difference was better visual acuity in the preferred eye.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Meeting Abstract
Ophthalmology
Bryce Chiang, Roopa Dalal, Kathleen Heng, Yaping Joyce Liao, Jeffrey L. Goldberg, David Myung
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Jonah P. Sengupta, Martin Villemur, Philippe O. Pouliquen, Pedro Julian, Andreas G. Andreou
Summary: This paper presents a neuromorphic signal processing pipeline that reduces energy consumption, increases signal-to-noise ratio, and improves algorithm performance by sparsifying the event stream. The pipeline is integrated within a system-on-chip platform for prototyping different standards compliant hardware modules.
2022 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS 22)
(2022)
Proceedings Paper
Automation & Control Systems
Martin Villemur, Jonah P. Sengupta, Pedro Julian, Andreas G. Andreou
Summary: This paper presents a high-speed object detection algorithm that uses data from an event-based camera and a spike-based, cellular neural network framework. The algorithm processes the asynchronous event data in parallel and produces object blobs, shape skeletons, and centroids for low-latency object detection.
2022 8TH INTERNATIONAL CONFERENCE ON EVENT-BASED CONTROL, COMMUNICATION AND SIGNAL PROCESSING (EBCCSP 2022)
(2022)
Meeting Abstract
Ophthalmology
Bryce Chiang, Edward E. Manche
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemical Research Methods
Cheng-Hui Lin, Young Joo Sun, Soo Hyeon Lee, Elena M. Mujica, Caitlin R. Kunchur, Man-Ru Wu, Jing Yang, Youn Soo Jung, Bryce Chiang, Sui Wang, Vinit B. Mahajan
Summary: The study presents a cost-effective and minimally invasive protocol, MI3, for delivering ODIs into the mouse vitreous. This approach provides an alternative injection method for small-eyed model organisms and expands the preclinical platforms for evaluating ODIs' efficacy, toxicity, and pharmacokinetics.
Article
Biochemical Research Methods
Young Joo Sun, Cheng-Hui Lin, Man-Ru Wu, Soo Hyeon Lee, Jing Yang, Caitlin R. Kunchur, Elena M. Mujica, Bryce Chiang, Youn Soo Jung, Sui Wang, Vinit B. Mahajan
Summary: The translation discusses the limitations of using small molecule drugs to treat eye diseases and introduces a new method, MI3, to deliver ODIs into mouse eyes. This method aims to expand ODI research to cover a wide range of human eye diseases modeled in mice.
CELL REPORTS METHODS
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Jonah P. Sengupta, Martin Villemur, Daniel R. Mendat, Gaspar Tognetti, Andreas G. Andreou
Summary: This paper presents an event-based accelerator system for neuromorphic cameras, exploring architecture and algorithms for tasks such as noise filtering, corner detection, and object tracking. The system includes a RISC-V CPU and peripherals to capture and process event-based visual data, demonstrating functionality on a reconfigurable computing platform (FPGA).
2021 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS)
(2021)
Proceedings Paper
Computer Science, Information Systems
Jonah P. Sengupta, Martin Villemur, Andreas G. Andreou
Summary: The paper introduces a foundation and architecture for a spike-based, neuromorphic cellular neural network, which processes spike information from a dynamic vision sensor asynchronously. Spatiotemporal filtering of spike data is achieved through mixed-signed, embedded morphological processing, and preliminary simulation and modeling indicate a clear pathway towards realizing the architecture in hardware.
2021 55TH ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS (CISS)
(2021)
Proceedings Paper
Computer Science, Information Systems
Jonah P. Sengupta, Martin Villemur, Andreas G. Andreou
Summary: Neuromorphic vision sensors offer a low-power, bandwidth efficient method for extracting visual information, making them suitable for energy-efficient embedded systems. An algorithm for embedded, event-driven feature extraction and object tracking has been outlined, showing significant data reduction, improved throughput of feature extraction, and sustained event processing rate.
2021 55TH ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS (CISS)
(2021)
Proceedings Paper
Computer Science, Information Systems
Daniel R. Mendat, Jonah P. Sengupta, Drake K. Foreman, Andreas G. Andreou
Summary: A graphical framework has been demonstrated to approximate visual features from spike-based sensor data, utilizing event-based camera input to compute optical flow, spatial gradient, and intensity in parallel for incremental optimization. An event-based algorithm was used to compute optical flow and aid network convergence. The full network has been deployed in Python and parallelized for potential specialized hardware deployment.
2021 55TH ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS (CISS)
(2021)