Intestinal Bacteriophage Therapy: Looking for Optimal Efficacy

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

(2021) Fernando Gordillo Altamirano et al.   Nature Microbiology

Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice

(2021) Bahtiyar Yilmaz et al.   Cell Host & Microbe

Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract

(2021) Sabrina I. Green et al.   mBio

Bacteriophage uptake by mammalian cell layers represents a potential sink that may impact phage therapy

(2021) Marion C. Bichet et al.   iScience

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Bacteriophages Isolated from Stunted Children Can Regulate Gut Bacterial Communities in an Age-Specific Manner

(2020) Mohammadali Khan Mirzaei et al.   Cell Host & Microbe

Myoviridae phage PDX kills enteroaggregative Escherichia coli without human microbiome dysbiosis

(2020) Leah C. S. Cepko et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages

(2020) Aurélie Mathieu et al.   Nature Communications

The Yersinia Phage X1 Administered Orally Efficiently Protects a Murine Chronic Enteritis Model Against Yersinia enterocolitica Infection

(2020) Yibing Xue et al.   Frontiers in Microbiology

In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials

(2020) Kurt Selle et al.   mBio

The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages

(2020) Marta Lourenço et al.   Cell Host & Microbe

The population genetics of pathogenic Escherichia coli

(2020) Erick Denamur et al.   NATURE REVIEWS MICROBIOLOGY

Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri

(2019) Jee-Hwan Oh et al.   Cell Host & Microbe

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Biodistribution of Liposome-Encapsulated Bacteriophages and Their Transcytosis During Oral Phage Therapy

(2019) Jennifer Otero et al.   Frontiers in Microbiology

Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model

(2019) Bryan B. Hsu et al.   Cell Host & Microbe

Eradication of a multi-drug resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom-made, lytic bacteriophage preparation

(2019) Mario Corbellino et al.   CLINICAL INFECTIOUS DISEASES

Bacteriophages Reduce Pathogenic Escherichia coli Counts in Mice Without Distorting Gut Microbiota

(2019) Upuli Dissanayake et al.   Frontiers in Microbiology

Microencapsulation of Enteric Bacteriophages in a pH-Responsive Solid Oral Dosage Formulation Using a Scalable Membrane Emulsification Process

(2019) Vinner et al.   Pharmaceutics

The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

(2019) Andrey N. Shkoporov et al.   Cell Host & Microbe

The pan-immune system of bacteria: antiviral defence as a community resource

(2019) Aude Bernheim et al.   NATURE REVIEWS MICROBIOLOGY

Whole-Virome Analysis Sheds Light on Viral Dark Matter in Inflammatory Bowel Disease

(2019) Adam G. Clooney et al.   Cell Host & Microbe

Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes

(2018) Geicho Nakatsu et al.   GASTROENTEROLOGY

Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians

(2018) Celeste Allaband et al.   Clinical Gastroenterology and Hepatology

Reviving Phage Therapy for the Treatment of Cholera

(2018) Sudhakar Bhandare et al.   JOURNAL OF INFECTIOUS DISEASES

Diagnostic Potential and Interactive Dynamics of the Colorectal Cancer Virome

(2018) Geoffrey D. Hannigan et al.   mBio

Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation

(2018) L. A. Draper et al.   Microbiome

Persistent diarrhea: a persistent infection with enteropathogens or a gut commensal dysbiosis?

(2017) Shafiqul A. Sarker et al.   ENVIRONMENTAL MICROBIOLOGY

What happened to Koch's postulates in diarrhoea?

(2017) Shamima Sultana et al.   ENVIRONMENTAL MICROBIOLOGY

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection

(2017) Stephan J. Ott et al.   GASTROENTEROLOGY

Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing

(2017) Zhong Peng et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Inflammation boosts bacteriophage transfer between Salmonella spp.

(2017) Médéric Diard et al.   SCIENCE

A cocktail of three virulent bacteriophages prevents Vibrio cholerae infection in animal models

(2017) Minmin Yen et al.   Nature Communications

Efficacy of Phage Therapy in Controlling Rabbit Colibacillosis and Changes in Cecal Microbiota

(2017) Jian Zhao et al.   Frontiers in Microbiology

Bacteriophages to reduce gut carriage of antibiotic resistant uropathogens with low impact on microbiota composition

(2016) Matthieu Galtier et al.   ENVIRONMENTAL MICROBIOLOGY

Oral application ofEscherichia colibacteriophage: safety tests in healthy and diarrheal children from Bangladesh

(2016) Shafiqul Alam Sarker et al.   ENVIRONMENTAL MICROBIOLOGY

Synergistic interaction between phage therapy and antibiotics clears Pseudomonas aeruginosa infection in endocarditis and reduces virulence

(2016) Frank Oechslin et al.   JOURNAL OF INFECTIOUS DISEASES

Healthy human gut phageome

(2016) Pilar Manrique et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis for Lytic Bacteriophage Resistance in Enterococci

(2016) Breck A. Duerkop et al.   mBio

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

Oral and Rectal Administration of Bacteriophages for Control of Escherichia coli O157:H7 in Feedlot Cattle

(2016) ERICA A. ROZEMA et al.   JOURNAL OF FOOD PROTECTION

Oral Delivery Systems for Encapsulated Bacteriophages Targeted at Escherichia coli O157:H7 in Feedlot Cattle

(2016) K. STANFORD et al.   JOURNAL OF FOOD PROTECTION

Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo

(2015) Janet Y. Nale et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

A century of the phage: past, present and future

(2015) George P. C. Salmond et al.   NATURE REVIEWS MICROBIOLOGY

Isolation, Characterization, and Application of Bacteriophages for Salmonella spp. Biocontrol in Pigs

(2014) Luiz A.A. Albino et al.   Foodborne Pathogens and Disease

Comparative analysis of different oral approaches to treat Vibrio cholerae infection in adult mice

(2014) Abhishek Jaiswal et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa

(2014) Shuai Le et al.   Scientific Reports

Novel approach of using a cocktail of designed bacteriophages against gut pathogenic E. colifor bacterial load biocontrol

(2014) Ahmed Sahib Abdulamir et al.   Annals of Clinical Microbiology and Antimicrobials

Clostridium difficile phages: still difficult?

(2014) Katherine R. Hargreaves et al.   Frontiers in Microbiology

Host Exopolysaccharide Quantity and Composition Impact Erwinia amylovora Bacteriophage Pathogenesis

(2013) Dwayne R. Roach et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metagenomic species profiling using universal phylogenetic marker genes

(2013) Shinichi Sunagawa et al.   NATURE METHODS

Bacteriophage adhering to mucus provide a non-host-derived immunity

(2013) J. J. Barr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulent Bacteriophages Can Target O104:H4 Enteroaggregative Escherichia coli in the Mouse Intestine

(2012) Damien Maura et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophages  MR299-2 and  NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells

(2012) D. Alemayehu et al.   mBio

Intestinal colonization by enteroaggregative Escherichia coli supports long-term bacteriophage replication in mice

(2011) Damien Maura et al.   ENVIRONMENTAL MICROBIOLOGY

Direct Feeding of Microencapsulated Bacteriophages to Reduce Salmonella Colonization in Pigs

(2011) Anthea C. Saez et al.   Foodborne Pathogens and Disease

Bacteriophage-Resistant Mutants in Yersinia pestis: Identification of Phage Receptors and Attenuation for Mice

(2011) Andrey A. Filippov et al.   PLoS One

In Vivo and Ex Vivo Evaluations of Bacteriophages e11/2 and e4/1c for Use in the Control of Escherichia coli O157:H7

(2010) L. Rivas et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions

(2010) Julia Garbe et al.   BMC MICROBIOLOGY

Evaluation of Phage Treatment as a Strategy to Reduce Salmonella Populations in Growing Swine

(2010) Todd R. Callaway et al.   Foodborne Pathogens and Disease

Effect of probiotic-, bacteriophage-, or organic acid-supplemented feeds or fermented soybean meal on the growth performance, acute-phase response, and bacterial shedding of grower pigs challenged with Salmonella enterica serotype Typhimurium1

(2010) E. Gebru et al.   JOURNAL OF ANIMAL SCIENCE

Bacteriophages Can Treat and PreventPseudomonas aeruginosaLung Infections

(2010) Laurent Debarbieux et al.   JOURNAL OF INFECTIOUS DISEASES

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions

(2010) Marcus J. Claesson et al.   NUCLEIC ACIDS RESEARCH

Phage Therapy To Reduce Preprocessing Salmonella Infections in Market-Weight Swine

(2009) S. K. Wall et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

T4 phages against Escherichia coli diarrhea: Potential and problems

(2009) Emmanuel Denou et al.   VIROLOGY

In vivo replication of T4 and T7 bacteriophages in germ-free mice colonized with Escherichia coli

(2009) Marietta Weiss et al.   VIROLOGY

Bacteriophage Isolated from Feedlot Cattle Can Reduce Escherichia coli O157:H7 Populations in Ruminant Gastrointestinal Tracts

(2008) Todd R. Callaway et al.   Foodborne Pathogens and Disease

Comparative Analysis of Human Gut Microbiota by Barcoded Pyrosequencing

(2008) Anders F. Andersson et al.   PLoS One

Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli O149 infection of pigs

(2008) Nidham Jamalludeen et al.   VETERINARY MICROBIOLOGY