Article
Gastroenterology & Hepatology
Huapeng Lin, Terry Cheuk-Fung Yip, Xinrong Zhang, Guanlin Li, Yee-Kit Tse, Vicki Wing-Ki Hui, Lilian Yan Liang, Jimmy Che-To Lai, Stephen Lam Chan, Henry Lik-Yuen Chan, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Summary: The relative importance of liver-related death increases with age in patients with NAFLD, especially among women.
Article
Medicine, General & Internal
Arun J. Sanyal, Mark L. Van Natta, Jeanne Clark, Brent A. Neuschwander-Tetri, AnnaMae Diehl, Srinivasan Dasarathy, Rohit Loomba, Naga Chalasani, Kris Kowdley, Bilal Hameed, Laura A. Wilson, Katherine P. Yates, Patricia Belt, Mariana Lazo, David E. Kleiner, Cynthia Behling, James Tonascia
Summary: In this study involving patients with nonalcoholic fatty liver disease, advanced fibrosis stages F3 and F4 were associated with increased risks of liver-related complications and death over a median of 4 years of follow-up. Advanced fibrosis was also related to an increased incidence of liver decompensation events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Margarita Papatheodoridi, Giada Pallini, Guruprasad Aithal, Hong Kai Lim, Jeremy Cobbold, Maria Corina Plaz Torres, Marta Guerrero Misas, John Ryan, Jeremy Tomlinson, Michael Allison, Louise Longworth, Emmanuel A. Tsochatzis
Summary: Patients with nonalcoholic fatty liver disease (NAFLD), even without advanced fibrosis, have worse health-related quality of life (HRQoL) compared to the general population. In NAFLD patients without advanced fibrosis, HRQoL is associated with non-liver comorbidities, but not liver stiffness.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Atsushi Nakamura, Tsubasa Yoshimura, Hitoshi Asakura
Summary: This study investigated the relationship between hepatic fat loss and malnutrition in chronic liver disease using magnetic resonance imaging. The results showed that decreased body fat mass and triglycerides, as well as increased nutritional assessment score, were associated with hepatic fat loss. Furthermore, hepatic fat loss and Child-Pugh score were identified as independent prognostic factors for patients with cirrhosis. These findings emphasize the importance of preserving liver fat content in nutritional therapy for cirrhotic patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Surgery
Timothy J. Vreeland, Fadi M. Balla, Edward Lin, S. Scott Davis, Christopher G. Yheulon
Summary: Patients with cirrhosis and ascites undergoing non-emergent laparoscopic cholecystectomy have higher rates of overall morbidity and mortality compared to those without ascites. However, when the MELD score is less than or equal to 9, there is no significant difference in morbidity and mortality compared to patients without ascites. Patients with a MELD score greater than 9 have significantly higher rates of both morbidity and mortality.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Luca Saverio Belli, Christophe Duvoux, Paolo Angelo Cortesi, Rita Facchetti, Speranta Iacob, Giovanni Perricone, Sylvie Radenne, Sara Conti, Damiano Patrono, Gabriela Berlakovich, Angus Hann, Luisa Pasulo, Lluis Castells, Francois Faitot, Olivier Detry, Federica Invernizzi, Giulia Magini, Paolo De Simone, Ilias Kounis, Maria Cristina Morelli, Fernando Diaz Fontenla, Bo-Goran Ericzon, Carmelo Loinaz, Chris Johnston, Liliana Gheorghe, Mickael Lesurtel, Renato Romagnoli, Dagmar Kollmann, M. Thamara P. R. Perera, Stefano Fagiuoli, Darius Mirza, Audrey Coilly, Christian Toso, Krzysztof Zieniewicz, Laure Elkrief, Vincent Karam, Rene Adam, Caroline den Hoed, Marco Merli, Massimo Puoti, Luciano De Carlis, Gabriel C. Oniscu, Salvatore Piano, Paolo Angeli, Constantino Fondevila, Wojciech G. Polak
Summary: COVID-19 significantly impacts the mortality rate of liver transplant candidates, especially for those with high Lab-MELD scores and respiratory symptoms. Poor prognosis was observed in patients with decompensated cirrhosis, highlighting the need for strict preventive measures and urgent vaccination efficacy testing in this population. Prior symptomatic SARS-CoV-2 infection did not affect early post-transplant survival.
Article
Multidisciplinary Sciences
Norihisa Nishimura, Davide De Battista, David R. McGivern, Ronald E. Engle, Ashley Tice, Rafaelle Fares-Gusmao, Juraj Kabat, Anna Pomerenke, Hanh Nguyen, Shinya Sato, Kevin W. Bock, Ian N. Moore, David E. Kleiner, Fausto Zamboni, Harvey J. Alter, Sugantha Govindarajan, Patrizia Farci
Summary: This study found that CHI3L1 promotes liver fibrogenesis through a direct effect on HSCs, supporting a role for CHI3L1 in the increased susceptibility of aging livers to fibrosis progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Manuel Romero-Gomez, Mauro Vigano, Elisabetta Bugianesi, Vincent W. -s Wong, Anna Ludovica Fracanzani, Giada Sebastiani, Jerome Boursier, Annalisa Berzigotti, Mohammed Eslam, Javier Ampuero, Amine Benmassaoud, Claudia La Mantia, Yuly P. Mendoza, Jacob George, Antonio Craxi, Calogero Camma', Victor de Ledinghen, Salvatore Petta
Summary: The occurrence of extrahepatic events (EHE) in patients with non-alcoholic fatty liver disease (NAFLD) is relevant and increases according to the severity of liver fibrosis, while the risk of liver-related events (LRE) is low in patients with mild fibrosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Xinrong Zhang, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip, Johnny T. K. Cheung, Yee-Kit Tse, Vicki Wing-Ki Hui, Huapeng Lin, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Alice Pik-Shan Kong, Vincent Wai-Sun Wong
Summary: The duration of T2D is not associated with the occurrence of liver-related events, while age is. Therefore, screening for liver disease in patients with NAFLD and T2D starting at the age of 50 is reasonable.
Article
Gastroenterology & Hepatology
Kustaa Saarinen, Martti Farkkila, Antti Jula, Iris Erlund, Terhi Vihervaara, Annamari Lundqvist, Fredrik Aberg
Summary: The Enhanced Liver Fibrosis (ELF) test exhibits good performance in predicting liver-related outcomes, especially for patients with risk factors, and can predict outcomes for up to five years.
Article
Pharmacology & Pharmacy
Fu-Shun Yen, Ming-Chih Hou, James Cheng-Chung Wei, Ying-Hsiu Shih, Chung Y. Hsu, Chih-Cheng Hsu, Chii-Min Hwu
Summary: This study investigated the long-term outcomes of alpha-glucosidase inhibitors (AGIs) in patients with diabetes and cirrhosis. The results showed that AGI users had significantly lower risks of mortality, hepatocellular carcinoma, decompensated cirrhosis, hepatic encephalopathy, and hepatic failure compared to non-users.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Rohit Loomba, Daniel Q. Huang, Arun J. Sanyal, Quentin Mark Anstee, Michael Trauner, Eric J. Lawitz, Dora Ding, Lily Ma, Catherine Jia, Andrew Billin, Ryan S. Huss, Chuhan Chung, Zachary Goodman, Vincent Wai-Sun Wong, Takeshi Okanoue, Manuel Romero-Gomez, Manal F. Abdelmalek, Andrew Muir, Nezam Afdhal, Jaime Bosch, Stephen Harrison, Zobair M. Younossi, Robert P. Myers
Summary: In patients with non-alcoholic steatohepatitis (NASH), liver stiffness (LS) measured by vibration-controlled transient elastography (VCTE) can predict the progression of cirrhosis and the risk of liver decompensation.
Article
Gastroenterology & Hepatology
Lorenz Balcar, Bernhard Scheiner, Markus Urheu, Patrick Weinberger, Rafael Paternostro, Benedikt Simbrunner, Georg Semmler, Claudia Willheim, Matthias Pinter, Peter Ferenci, Michael Trauner, Thomas Reiberger, Albert Friedrich Staettermayer, Mattias Mandorfer
Summary: The TM6SF2 rs58542926 SNP can modulate the susceptibility for (advanced) chronic liver disease ([A]CLD). It was found that harboring the TM6SF2 T-allele increased the risk of hepatic decompensation/liver transplantation/liver-related death, independently of baseline liver disease severity.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Sumeet K. Asrani, Jessica Mellinger, Juan P. Arab, Vijay H. Shah
Summary: Alcohol-associated liver disease is a major global health issue, requiring comprehensive solutions that focus on early identification and intervention, reducing alcohol consumption, tailoring solutions to local realities, and integrating medical and AUD treatment. Future efforts should focus on improving data quality, supporting innovative healthcare delivery platforms, advocating for professional hepatology organizations, and advancing digital interventions.
Article
Gastroenterology & Hepatology
Fredrik Aberg, Kustaa Saarinen, Antti Jula, Annamari Lundqvist, Terhi Vihervaara, Iris Erlund, Martti Farkkila
Summary: This study evaluated the predictive performance of a combination of liver fibrosis assessment, phenotype profile, and genetic risk in predicting liver-related outcomes. The combination of the chronic liver disease risk score and the enhanced liver fibrosis test significantly improved the predictive performance compared to the enhanced liver fibrosis test alone. The addition of the polygenic risk score did not significantly increase the predictive performance.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Hideki Fujii, Naotoshi Nakamura, Shinya Fukumoto, Tatsuo Kimura, Akemi Nakano, Yuji Nadatani, Yukie Tauchi, Yuuko Nishii, Shingo Takashima, Yoshihiro Kamada, Toshio Watanabe, Norifumi Kawada
Summary: The number of new MAFLD diagnoses increased during the COVID-19 pandemic, particularly in participants aged <60 years, with higher daily alcohol intake and frequency of meals being associated with a higher risk of MAFLD development. Lifestyle factors should be closely monitored and addressed in this age group as the pandemic continues.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Yuya Seko, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Takeshi Okanoue, Yoshito Itoh, Atsushi Nakajima
Summary: Type 2 diabetes mellitus and obesity are risk factors for liver-related events (LRE) in patients with non-alcoholic fatty liver disease (NAFLD) in Japan, with different impacts based on age. Controlling diabetes in patients younger than 65 and weight in patients 65 and older can help prevent LRE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Michihiro Iwaki, Takaomi Kessoku, Kosuke Tanaka, Anna Ozaki, Yuki Kasai, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Shunsuke Oyamada, Noritoshi Kobayashi, Shinichi Aishima, Satoru Saito, Atsushi Nakajima, Masato Yoneda
Summary: The long-term prognosis of non-obese NAFLD patients is controversial, as some cases may have a poor prognosis such as extrahepatic cancers. Further validation is required in the future.
Article
Gastroenterology & Hepatology
Hiroshi Ishiba, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue
Summary: This study aimed to examine the prognostic accuracy of noninvasive tests (NITs) for liver-related mortality (LRM) and events (LREs) in patients with nonalcoholic fatty liver disease (NAFLD). The results showed that NITs can accurately predict LRM and LREs, and can be an alternative method for the prognosis assessment of NAFLD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Yoshinari Matsumoto, Hideki Fujii, Mika Harima, Haruna Okamura, Yoshimi Yukawa-Muto, Naoshi Odagiri, Hiroyuki Motoyama, Kohei Kotani, Ritsuzo Kozuka, Etsushi Kawamura, Atsushi Hagihara, Sawako Uchida-Kobayashi, Masaru Enomoto, Yoko Yasui, Daiki Habu, Norifumi Kawada
Summary: This study found that the Japanese diet pattern was associated with the severity of liver fibrosis in Japanese patients with NAFLD. Skeletal muscle mass was also associated with the severity of liver fibrosis, as well as intake of soybeans and soybean foods.
Article
Nutrition & Dietetics
Hirokazu Takahashi, Miwa Kawanaka, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takeshi Okanoue
Summary: This study analyzed the relationship between baseline serum albumin level and long-term prognosis in 1383 Japanese patients with NAFLD. The results showed that patients with intermediate or low serum albumin had a significantly higher risk of death or orthotopic liver transplantation.
Letter
Gastroenterology & Hepatology
Hideki Fujii, Hirokazu Takahashi, Yoshihiro Kamada, Yoshio Sumida, Atsushi Nakajima
Article
Gastroenterology & Hepatology
Hideki Fujii, Yuichiro Suzuki, Koji Sawada, Miwa Tatsuta, Tatsuji Maeshiro, Hiroshi Tobita, Tsubasa Tsutsumi, Takemi Akahane, Chitomi Hasebe, Miwa Kawanaka, Takaomi Kessoku, Yuichiro Eguchi, Hayashi Syokita, Atsushi Nakajima, Tomoari Kamada, Hitoshi Yoshiji, Takumi Kawaguchi, Hiroshi Sakugawa, Asahiro Morishita, Tsutomu Masaki, Takumi Ohmura, Toshio Watanabe, Norifumi Kawada, Yoshioki Yoda, Nobuyuki Enomoto, Masafumi Ono, Kanako Fuyama, Kazufumi Okada, Naoki Nishimoto, Yoichi M. Ito, Yoshihiro Kamada, Hirokazu Takahashi, Yoshio Sumida
Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Japan is approximately one-quarter of the general population, with higher rates among men than women. Regardless of obesity, there is a linear relationship between NAFLD prevalence and body mass index, triglycerides, and low-density lipoprotein cholesterol. Some patients with fatty liver also have diabetes, hypertension, and dyslipidemia. The prevalence of NAFLD with advanced fibrosis is estimated to be 1%-2%.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Yoko Futani, Megumi Hamano, Riku Matsumoto, Saya Hashimoto, Rikuto Nishimura, Mika Ueda, Narumi Arihara, Hideki Fujii, Masafumi Ono, Eiji Miyoshi, Shigeyoshi Saito, Yoshihiro Kamada
Summary: Elastography is used clinically to diagnose liver stiffness. This study developed a shear-wave elastography (SWE) measurement method using ultrasound in mice and compared it with other noninvasive tests for liver fibrosis. Results showed that SWE values significantly increased in liver fibrosis mice and were positively correlated with T-1rho values and serum M2BP levels. This method can noninvasively assess the degree of liver fibrosis.
GASTROINTESTINAL DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Yoshihiro Kamada, Takashi Nakahara, Kensuke Munekage, Hideki Fujii, Yoshiyuki Sawai, Yoshinori Doi, Masafumi Ono, Hideyuki Hyogo, Yoshio Sumida, Koichi Morishita, Tatsuya Asuka, Tsunenori Ouchida, Yasuharu Imai, Eiji Miyoshi
Summary: The study found that M2BP is a useful biomarker for predicting liver-related events, especially HCC, and may also be a potential predictive biomarker for colorectal cancer development.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Shingo Fujita, Emi Horitani, Yohei Miyashita, Yukari Fujita, Kenji Fukui, Yoshihiro Kamada, Ikuo Mineo, Yoshihiro Asano, Hiromi Iwahashi, Junji Kozawa, Iichiro Shimomura
Summary: Hyperinsulinemia can occur in nonobese subjects with unknown etiology. This study reports a case of a 72-year-old man with hyperinsulinemia, reactive hypoglycemia, and liver dysfunction. Whole-exome sequencing analysis identified genetic variants in the insulin receptor (INSR), AKT1, and PHKA2 genes, which may be associated with the hyperinsulinemia and hepatic-type glycogenosis.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Gastroenterology & Hepatology
Hirokazu Takahashi, Takaomi Kessoku, Miwa Kawanaka, Michihiro Nonaka, Hideyuki Hyogo, Hideki Fujii, Tomoaki Nakajima, Kento Imajo, Kenichi Tanaka, Yoshihito Kubotsu, Hiroshi Isoda, Satoshi Oeda, Osamu Kurai, Masato Yoneda, Masafumi Ono, Yoichiro Kitajima, Ryo Tajiri, Ayako Takamori, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Atsushi Nakajima, Yuichiro Eguchi, Keizo Anzai
Summary: Long-term treatment with ipragliflozin improves hepatic fibrosis in patients with NAFLD and may be effective for treating and preventing NASH in diabetes patients, while also improving glycemic control and obesity. Further larger studies are needed to confirm these effects.
HEPATOLOGY COMMUNICATIONS
(2022)
