Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease

Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study

(2021) Usman A. Tahir et al.   Circulation-Heart Failure

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

(2021) Daniel Taliun et al.   NATURE

Multi-Omic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults

(2021) Daniel H. Katz et al.   Circulation-Genomic and Precision Medicine

LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations

(2020) Timothy A. Myers et al.   Frontiers in Genetics

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

(2020) Laura M. Raffield et al.   PROTEOMICS

Key genes of renal tubular necrosis: a bioinformatics analysis

(2020) Peng Lin et al.   Translational Andrology and Urology

The Duffy-null genotype and risk of infection

(2020) Sophie E Legge et al.   HUMAN MOLECULAR GENETICS

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

(2020) Xihao Li et al.   NATURE GENETICS

Call to Action: Structural Racism as a Fundamental Driver of Health Disparities: A Presidential Advisory From the American Heart Association

(2020) Keith Churchwell et al.   CIRCULATION

A fully adjusted two-stage procedure for rank-normalization in genetic association studies

(2019) Tamar Sofer et al.   GENETIC EPIDEMIOLOGY

NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice

(2019) Xiwen Xiong et al.   PLoS One

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci

(2019) Joel Gelernter et al.   BIOLOGICAL PSYCHIATRY

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

(2019) Mihir A Kamat et al.   BIOINFORMATICS

Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program

(2019) Alexander G. Bick et al.   CIRCULATION

C-X-C Ligand 16 Is an Independent Predictor of Cardiovascular Death and Morbidity in Acute Coronary Syndromes

(2019) Thomas Andersen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Emerging Affinity Reagents for High Throughput Proteomics

(2019) Mark D. Benson et al.   CIRCULATION

ApoE Genotype, Lipid Profile, Exercise, and the Associations With Cardiovascular Morbidity and 18-Year Mortality

(2019) Rachel Dankner et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A resource-efficient tool for mixed model association analysis of large-scale data

(2019) Longda Jiang et al.   NATURE GENETICS

Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression

(2018) Yang Li et al.   Journal of Hematology & Oncology

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

(2018) Luke M. Evans et al.   NATURE GENETICS

Association of Neutrophil-to-Lymphocyte Ratio With Mortality and Cardiovascular Disease in the Jackson Heart Study and Modification by the Duffy Antigen Variant

(2018) Stephanie Kim et al.   JAMA Cardiology

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

(2018) John D. Belcher et al.   PLoS One

Co-regulatory networks of human serum proteins link genetics to disease

(2018) Valur Emilsson et al.   SCIENCE

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

(2018) Chen Yao et al.   Nature Communications

Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans

(2018) Linda M Polfus et al.   HUMAN MOLECULAR GENETICS

The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors?

(2018) Maxime M Bos et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

Association of Cardiac Injury and Malignant Left Ventricular Hypertrophy With Risk of Heart Failure in African Americans

(2018) Ambarish Pandey et al.   JAMA Cardiology

Plasminogen activator inhibitor-1 regulates the vascular expression of vitronectin

(2017) M. Luo et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ClinVar: improving access to variant interpretations and supporting evidence

(2017) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

(2017) Lasse Folkersen et al.   PLoS Genetics

Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model

(2017) Marios Arvanitis et al.   JAMA Cardiology

Genetic Architecture of the Cardiovascular Risk Proteome

(2017) Mark D. Benson et al.   CIRCULATION

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular DiseaseClinical Perspective

(2016) Debby Ngo et al.   CIRCULATION

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Unified representation of genetic variants

(2015) Adrian Tan et al.   BIOINFORMATICS

LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants: Fig. 1.

(2015) Mitchell J. Machiela et al.   BIOINFORMATICS

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

Robust Inference of Population Structure for Ancestry Prediction and Correction of Stratification in the Presence of Relatedness

(2015) Matthew P. Conomos et al.   GENETIC EPIDEMIOLOGY

Recommendations on the Use of Echocardiography in Adult Hypertension: A Report from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE)†

(2015) Thomas H. Marwick et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Coagulation factor XII genetic variation,ex vivothrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study

(2015) N. C. Olson et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

Cholesterol Lowering Modulates T Cell Function In Vivo and In Vitro

(2014) Kuang-Yuh Chyu et al.   PLoS One

Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability

(2014) Erika Assarsson et al.   PLoS One

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Increased Burden of Cardiovascular Disease in Carriers of APOL1 Genetic Variants

(2013) Kaoru Ito et al.   CIRCULATION RESEARCH

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling

(2012) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

(2011) Muredach P Reilly et al.   LANCET

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry

(2009) H. Kulkarni et al.   BLOOD