Article
Pharmacology & Pharmacy
Haodong Hou, Bin Qu, Chen Su, Guihua Hou, Feng Gao
Summary: The designed and synthesized hybrids showed higher antiproliferative activity against lung cancer cell lines compared to the parent drug, while exhibiting no cytotoxicity towards normal cells. The structure-activity relationships revealed the significant influence of substituents on the isatin moiety on the activity of the hybrids.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming-Fang Wu, Yen-Hsiang Huang, Ling-Yen Chiu, Shur-Hueih Cherng, Gwo-Tarng Sheu, Tsung-Ying Yang
Summary: Curcumin induces apoptosis in chemoresistant lung cancer cells through generation of ROS, and p38 MAPK is identified as a crucial signaling pathway for this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Su-Hyeon Cho, SeonJu Park, Hoibin Jeong, Song-Rae Kim, Myeong Seon Jeong, Miri Choi, Seung Hyun Kim, Kil-Nam Kim
Summary: The study demonstrates that HHMP significantly inhibits LPS-induced inflammatory responses by suppressing NO and prostaglandin production, regulating protein expression, and inhibiting NF-kappa B and MAPK activation. This suggests HHMP's potential as a natural anti-inflammatory agent.
Review
Oncology
Xiaodi Wu, Xin Hua, Ke Xu, Yong Song, Tangfeng Lv
Summary: Zebrafish is increasingly used as a model organism for lung cancer research due to its genetic and physiological similarities to humans. This review focuses on the insights gained from using zebrafish in lung cancer research, ranging from investigating genetic and molecular mechanisms to identifying potential drug targets, testing new therapies, and personalized medicine studies. The review provides a comprehensive overview of the current state of lung cancer research using zebrafish, highlighting the advantages and limitations of this model organism and discussing future directions in the field.
Article
Chemistry, Medicinal
Rajubai D. Bakale, Shubham M. Sulakhe, Sanghratna L. Kasare, Bhaurao P. Sathe, Sanket S. Rathod, Prafulla B. Choudhari, Estharla Madhu Rekha, Dharmarajan Sriram, Kishan P. Haval
Summary: A library of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives was synthesized and evaluated for their antitubercular activity. Two compounds showed excellent activity, while four compounds showed noticeable activity. The mechanism of action was studied and two compounds exhibited strong binding affinity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Amna A. Saddiq, Ali H. El-Far, Shymaa Abdullah Mohamed Abdullah, Kavitha Godugu, Omar A. Almaghrabi, Shaker A. Mousa
Summary: The combination of curcumin, thymoquinone, and 3, 3'-diindolylmethane exhibited anticancer effects on lung and liver cancer cells, inhibiting cell proliferation and migraton, inducing apoptosis, and reducing tumor weight and angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kitboklang Khongsti, Bala Gangadhar Pasupuleti, Bidyadhar Das, Ghanashyam Bez
Summary: A new compound 4T was synthesized, which showed anti-cancer effects on breast cancer cells by inducing apoptosis and reducing colony formation, migration, and invasion capabilities. Furthermore, it regulated the expression of key signaling pathway proteins.
BIOORGANIC CHEMISTRY
(2021)
Article
Spectroscopy
Suosuo An, Shuang Meng, Jiadan Xue, Huigang Wang, Xuming Zheng, Yanying Zhao
Summary: This paper investigates the photophysical and photochemical reactions of 1,2,4-triazole-3-thione in solid, protic, and aprotic solvents, confirming the structures of microsolvation clusters and identifying the intermolecular hydrogen bonding effects through a combination of experimental and computational methods. The results show significant spectrum shifts in Raman and absorption spectra of 3TT in different solvents, indicating the importance of hydrogen bonding interactions in the photophysical and photochemical processes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Min Wang, Longji Fang, Tongtong Liu, Xuejie Chen, Yan Zheng, Yilong Zhang, Shiming Chen, Zeng Li
Summary: The study evaluated a series of hesperetin derivatives for their multi-target-directed activities. Among them, compound a8 showed strong inhibition of cholinesterase, anti-neuroinflammatory activity, and neuroprotective effects. The results suggest that a8 has the potential to be developed as a multi-target-directed ligand for anti-Alzheimer's disease agents.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Toxicology
Li Zhang, Shichen Xu, Xian Cheng, Jing Wu, Liying Wu, Yunping Wang, Xiaowen Wang, Jiandong Bao, Huixin Yu
Summary: Curcumin significantly inhibits the growth of thyroid cancer cells by inducing autophagy through activation of the MAPK pathway and inhibition of the mTOR pathway. It exerts selective cytotoxicity on thyroid cancer cells without affecting normal epithelial cells, suggesting that inducing autophagic cell death may serve as a potential anti-cancer strategy for thyroid cancer.
TOXICOLOGY IN VITRO
(2022)
Article
Chemistry, Multidisciplinary
Phuong N. Nguyen, Thi-Bich-Ngoc Dao, Trang T. Tran, Ngoc-Anh T. Tran, Tu A. Nguyen, Thao-Dang L. Phan, Loc P. Nguyen, Vinh Q. Dang, Tuan M. Nguyen, Nam N. Dang
Summary: The current study investigates the electrocatalytic CO2 reduction of [Re(CO)3Cl(N-N)], where N-N represents different ligands. The results demonstrate that these complexes show enhanced catalytic activity and stability for CO2 reduction, which provides a new approach for electrocatalytic CO2 reduction.
Article
Chemistry, Organic
Alexander N. Koronatov, Kseniia K. Afanaseva, Pavel A. Sakharov, Nikolai V. Rostovskii, Alexander F. Khlebnikov, Mikhail S. Novikov
Summary: A new method for the synthesis of 1-alkyl-3-sulfonamido-1H-pyrroles via the Rh(ii)-catalyzed denitrogenative coupling of two different types of 1,2,3-triazoles has been developed. The reaction mechanism involves the attack of the rhodium-bound azavinyl carbene, leading to the formation of metal-free ylides and subsequent conversion to the desired products. This protocol provides high yields of 3-sulfonamidopyrroles, demonstrating promising synthetic applications.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Immunology
Hedieh Sadat Shamsnia, Mahtab Roustaei, Danial Ahmadvand, Alexandra E. Butler, Dorsa Amirlou, Sanam Soltani, Saeideh Momtaz, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
Summary: Curcumin, a herbal remedy, possesses anti-inflammatory, antioxidant, and anticancer properties and impacts various signaling pathways including NF-KB, ROS, Wnt, JAK/STAT. P38, a part of the MAPK signaling pathway, plays a crucial role in inflammation, cell differentiation, proliferation, motility, and survival. Extensive evidence confirms that curcumin exerts anti-inflammatory, neuroprotective, and apoptotic effects by modulating the P38 MAPK signaling pathway.
INFLAMMOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ching-Yee Loo, Daniela Traini, Paul M. Young, Thaigarajan Parumasivam, Wing-Hin Lee
Summary: The delivery of polyphenols, such as curcumin and quercetin, via inhalation can effectively treat lung cancer by increasing drug concentration in tumor cells. However, their applications have been limited by poor solubility and stability. In this study, inhaled curcumin nanoparticles and quercetin nanoparticles were shown to have enhanced anti-cancer activity in A549 cells compared to their individual formulations. Higher ratios of quercetin in the combination formulations induced more apoptosis, reduced ATP levels, generated more ROS, and caused MMP loss in A549 cells. The combination formulations also increased the expression of pro-apoptotic protein Bax. The toxicity of the formulations followed the trend: Cur-NPs: Que-NPs (1:4) > Cur-NPs: Que-NPs (2:3) > Cur-NPs: Que-NPs (3:2) > Cur-NPs: Que-NPs (4:1) > Cur-NPs only > Que-NPs only. Furthermore, both Cur-NPs and Que-NPs were internalized by cells through clathrin-mediated endocytosis. Overall, the combination of Cur-NPs and Que-NPs delivered via inhalation may serve as an alternative treatment for lung cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ling Gu, Zhihui Li, Xiongfei Zhang, Meijuan Chen, Xu Zhang
Summary: Myricetin has shown favorable biological activities in cancer, and it potentially inhibits the growth of non-small cell lung cancer (NSCLC) cells by targeting MKK3 and influencing the p38 MAPK signaling pathway. Network pharmacology revealed the modulating effect of myricetin on MAPK-related functions. The findings contribute to a better understanding of the molecular mechanisms of myricetin's pharmacological effects in cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)