Discovery of Isatin‐Based Carbohydrazones as Potential Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase

Design and synthesis of new carbamates as inhibitors for fatty acid amide hydrolase and cholinesterases: Molecular dynamic, in vitro and in vivo studies

(2021) Mahdi Faal Maleki et al.   BIOORGANIC CHEMISTRY

Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation

(2020) Yanguo Shang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of dual fatty acid amide hydrolase and cholinesterase inhibitory potential of some 3‐hydroxy‐3‐phenacyloxindole analogs

(2020) Rati K. P. Tripathi et al.   ARCHIV DER PHARMAZIE

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

(2019) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Cocktail Interaction Study Evaluating the Drug‐Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels

(2019) Nicoline Treijtel et al.   Clinical Pharmacology in Drug Development

Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases

(2019) M. S. Vishnu et al.   ChemMedChem

Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity

(2019) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenolic compounds from nutmeg ( Myristica fragrans Houtt.) inhibit the endocannabinoid‐modulating enzyme fatty acid amide hydrolase

(2019) Abir T. El‐Alfy et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors

(2018) Gaurav Bedse et al.   Translational Psychiatry

Scaffold hopping-guided design of some isatin based rigid analogs as fatty acid amide hydrolase inhibitors: Synthesis and evaluation

(2018) Shivani Jaiswal et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

(2018) Justin S. Cisar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site

(2017) Rati K. P. Tripathi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase

(2017) Christopher R. Butler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors

(2016) Bijo Mathew et al.   ChemMedChem

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition

(2016) Margherita Brindisi et al.   RSC Advances

Monoamine oxidase inhibitory activities of heterocyclic chalcones

(2015) Corné Minders et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors

(2015) María S. Aymerich et al.   MOLECULAR NEUROBIOLOGY

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

(2014) Jani Korhonen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model

(2014) Wayne B. Anderson et al.   NEUROPHARMACOLOGY

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

(2014) Harry R. Chobanian et al.   ACS Medicinal Chemistry Letters

Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis

(2011) Robert A. Copeland et al.   ANALYTICAL BIOCHEMISTRY

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)

(2011) Katerina Otrubova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling

(2009) Geoffray Labar et al.   CHEMBIOCHEM

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structural Basis for Human Monoglyceride Lipase Inhibition

(2009) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAY10499, a Novel Monoglyceride Lipase Inhibitor Evidenced by an Expeditious MGL Assay

(2008) Giulio G. Muccioli et al.   CHEMBIOCHEM

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA