Review
Chemistry, Medicinal
Hidetoshi Noda
Summary: This review highlights the author's research on catalytic reactions using isoxazolidin-5-ones as substrates. Asymmetric catalysis has been effective for C-C bond formation at the carbonyl alpha-carbon, leading to the development of catalytic asymmetric allylation and direct Mannich-type reactions. The resulting products can be further converted into quaternary beta(2,2)-amino acids, showcasing the potential utility of isoxazolidin-5-ones in various chemical sciences.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Review
Chemistry, Organic
Antonio Macchia, Andreas Eitzinger, Jean-Francois Briere, Mario Waser, Antonio Massa
Summary: Isoxazol-5-ones and isoxazolidin-5-ones are two important classes of heterocycles with various applications, and their asymmetric construction is particularly important. Chiral metal catalysts and organocatalysts have been successfully employed for the enantioselective synthesis of these heterocycles.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Multidisciplinary
Yuxiao Ding, Zhen-An Qiao
Summary: By analyzing various defects on the carbon surface, this article points out some commonly neglected aspects and misunderstandings in the field of carbon surface chemistry, clarifying how surface chemistry affects the chemical behaviors of carbon in specific chemical reactions. The importance of considering the carbon surface chemistry comprehensively and the prospects for future developments are also provided.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Applied
Chennattuparambil Roy Nathaniel, Mohan Neetha, Gopinathan Anilkumar
Summary: The pyrrole structure is crucial in many natural products, bioactive compounds, and organic materials, while silver catalysis has been widely used in organic synthesis with unique advantages for the facile and effective synthesis of pyrrole derivatives.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Paul Zebrowski, Katharina Roeser, Daniel Chrenko, Jiri Pospisil, Mario Waser
Summary: The enantioselective addition of isoxazolidin-5-ones to the α-carbon of allenoates has been achieved using a novel spirobiindane-based quaternary ammonium salt catalyst under classical liquid-solid phase-transfer conditions. This method provides unprecedented highly functionalized β(2,2)-amino acid derivatives with good enantioselectivities and high yields. Further manipulations of the products have also been conducted.
SYNTHESIS-STUTTGART
(2023)
Review
Chemistry, Multidisciplinary
Takashi Koike, Munetaka Akita
Summary: The electron is unique and has the ability to participate in various systems, with novel electron injection methods revolutionizing chemical bond formation techniques in organic synthesis. In particular, visible-light organic photoredox catalysis has rapidly spread among synthetic chemists due to its sustainability and versatility.
TRENDS IN CHEMISTRY
(2021)
Article
Chemistry, Organic
Singarajanahalli Mundarinti Krishna Reddy, Subramaniyan Prasanna Kumari, Subramaniapillai Selva Ganesan
Summary: The palladium-catalyzed addition of arylboronic acid to 2-cyano-(N-aryl)-acetamide or ethyl-2-cyanoacetate followed by subsequent reaction transforms them into biologically significant derivatives. The reaction conditions are robust enough to prevent hydrolysis of the ester/amide moiety during arylation, and can also convert the unactivated nitrile moiety in acetonitrile to the corresponding acetophenone derivative.
TETRAHEDRON LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Cristina Miralpeix, Ana Cristina Reguera, Anna Fosch, Sebastian Zagmutt, Nuria Casals, Daniela Cota, Rosalia Rodriguez-Rodriguez
Summary: The hypothalamus plays a crucial role in the pathogenesis of obesity, with disrupted endocannabinoid system considered a landmark indicator. Recent research has expanded knowledge of the complex endocannabinoid system, focusing on CB receptors, ligands, non-CB receptors, and metabolizing enzymes, particularly in the hypothalamus. The insights gained have provided promising targets for tackling obesity and related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Physical
Wu-Lin Yang, Yuan-Lin Wang, Wen Li, Bu-Ming Gu, Si-Wen Wang, Xiaoyan Luo, Bo-Xue Tian, Wei-Ping Deng
Summary: This study developed an efficient method for synthesizing 8-membered benzo[b]oxocines with high stereocontrol and yield through a sequential catalytic reaction. The chiral iridium catalyst was found to control enantioselectivity, while the chiral bifunctional squaramide catalyst controlled diastereoselectivity. The strategy was also demonstrated to be applicable for synthesizing other nitrogen heterocycles with high enantiomeric enrichment.
Article
Environmental Sciences
Zoltan Czajlik, Matyas Arvai, Janos Meszaros, Balazs Nagy, Laszlo Rupnik, Laszlo Pasztor
Summary: Cropmarks play a significant role in traditional aerial archaeology, particularly in Hungary as one of the most promising areas in Europe. The characteristics of soil are closely linked to the geological background, with remote sensing imagery and statistical methods aiding in understanding the variations in different study areas.
Article
Chemistry, Organic
Suven Das, Arpita Dutta
Summary: This review summarizes recent advances (2019-2023) in Rh-catalyzed annulation of various substrates for the synthesis of indole skeletons. The strategy offers mild reaction conditions, high efficiency, versatility, and regioselectivity. By utilizing readily available starting materials, functionalized indoles can be efficiently synthesized.
Article
Chemistry, Multidisciplinary
Anthony J. Burke, Amina Moutayakine
Summary: The benzilic acid rearrangement (BAR) is a powerful synthetic tool with important biological activity. Recent advancements, including the first catalytic asymmetric version, have highlighted the significance of stereoselectivity in this reaction.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ramakotaiah Mulamreddy, William D. Lubell
Summary: This paper reports the synthesis of 5- and 7-hydroxy indolizidin-2-one N-(Boc)amino acids from L-serine, and discusses their potential in peptide mimicry.
Review
Pharmacology & Pharmacy
Shuangling Yang, Hongzhi Yang, Yaxing Zhang
Summary: Type 2 diabetes mellitus, nonalcoholic fatty liver disease, cardio-cerebrovascular diseases, hyperuricemia and gout, and metabolic-related sexual dysfunction are metabolic diseases that affect human health. The findings from cell or animal models in previous research are challenging to apply clinically due to various differences. Traditional Chinese medicine has been used for over 2,200 years to maintain or improve cardiometabolic health, and our group has collected and studied the classic dietary treatments from ancient literature for metabolic diseases. The exact composition and active ingredients of these treatments are not standardized, and further research is needed.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Stergios Boussios, Elie Rassy, Eleftherios Samartzis, Michele Moschetta, Matin Sheriff, Jose Alejandro Perez-Fidalgo, Nicholas Pavlidis
Summary: Melanoma of unknown primary site (MUP) accounts for 3-4% of all melanomas and presents mostly in lymph nodes, subcutaneous sites, and visceral organs. MUP and stage-matched melanoma of known primary site (MKP) share similar prognostic factors, but treatment outcomes vary.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
