Article
Chemistry, Medicinal
Li Han, Aimei Chen, Ling Liu, Fang Wang
Summary: This study reveals that Leonurine (LEO) has a protective effect against ischemic AKI by activating Nrf2 nuclear translocation to resist oxidative stress injury and inhibiting the TLR4/NF-κB pathway mediated inflammatory gene expression.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Mohamed A. Morsy, Yasmine F. Ibrahim, Sara Mohamed Naguib Abdel Hafez, Nagwa M. Zenhom, Anroop B. Nair, Katharigatta N. Venugopala, Pottathil Shinu, Seham A. Abdel-Gaber
Summary: Paeonol can protect against hepatic ischemia/reperfusion injury by inhibiting oxidative stress, inflammation, and apoptosis.
Article
Biochemistry & Molecular Biology
Md Saifur Rahman, Md Badrul Alam, Young Kyun Kim, Mst Hur Madina, Ismail Fliss, Sang Han Lee, Jin Cheol Yoo
Summary: The novel antimicrobial peptide YD1 isolated from Kimchi exhibits strong anti-inflammatory effects by up-regulating the Nrf2 pathway and suppressing the NF-kappa B pathway, resulting in reduced proinflammatory cytokine production. YD1 also acts as a potent antioxidant by inhibiting NO and PGE(2) production, indicating its potential as a therapeutic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Kun Yan, Jianqiang Hu, Tianhua Hou, Xinxin Ci, Liping Peng
Summary: This study demonstrates that Leonurine (Leo) can effectively protect against carrageenan-induced pleurisy by inhibiting the TXNIP/NLRP3 and NF-kappa B pathways through activating the Nrf2 pathway, which may serve as a promising agent for attenuating pleurisy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Keyvan Amirshahrokhi, Mahsa Imani
Summary: This study aimed to investigate the potential protective effect of the antiepileptic drug levetiracetam against ulcerative colitis (UC) in mice. The results showed that levetiracetam can alleviate colonic mucosal injury in UC mice, promote antioxidant responses, reduce lipid peroxidation and myeloperoxidase activity, decrease inflammatory mediator expression, and increase anti-inflammatory cytokine levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Dabin Huang, Ping Wang, Juncao Chen, Yanbin Li, Mingwei Zhu, Yaping Tang, Wei Zhou
Summary: In this study, it was found that MD2 is significantly increased in patients with neonatal necrotizing enterocolitis (NEC). Pretreatment with MD2 inhibitor (MI) can reduce the occurrence and severity of NEC in rats, as well as alleviate intestinal mucosal injury and the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kefu Zhu, Xihao Wang, Yingzheng Weng, Genxiang Mao, Yizhong Bao, Jiangjie Lou, Shaoze Wu, Weihua Jin, Lijiang Tang
Summary: The study found that SWZ-4 extracted from Sargassum thunbergii can attenuate atherosclerosis in ApoE-KO mice by suppressing the TLR4/MyD88/NF-κB signaling pathway, indicating its potential as a treatment for atherosclerosis.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Immunology
Tao Lin, Ling Ding, Yicheng Lin, Chunbo Liu, Changzhen Wang, Dahao Wu, Zhe Li, Meng Li, Jinlong Sun
Summary: This study found that the use of TLR4 inhibitor TAK-242 can effectively prevent the occurrence of posthemorrhagic hydrocephalus and improve the prognosis. Its mechanism of action involves the regulation of the TLR4-NF-κB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seung Yong Kim, Dong-Uk Shin, Ji-Eun Eom, Sun Young Jung, Hyeon-Ji Song, Kyung Min Lim, Gun-Dong Kim, Soon-Il Yun, Mi-Yeon Kim, Hee Soon Shin, So-Young Lee
Summary: This study found that Artemisia gmelinii has a protective effect against lung inflammation caused by cigarette smoke. The mechanism of action may involve inhibiting the MAPK and NF-kappa B signaling pathways. This research provides a potential solution for improving respiratory and lung health.
Article
Immunology
Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin, Ye Xiong
Summary: The study found that hydroxychloroquine (HCQ) can improve neurological recovery in mice post-TBI by inhibiting the inflammatory response through the TLR4/NF-kappa B signaling pathway. HCQ reduces the expression of proinflammatory cytokines, attenuates blood-brain barrier (BBB) disruption and brain edema, and upregulates tight junction expression. This suggests that HCQ could be a potential therapeutic agent for TBI treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Environmental Sciences
Ali S. Alshehri, Attalla F. El-kott, Mohamed S. A. El-Gerbed, Ayman E. El-Kenawy, Ghadeer M. Albadrani, Heba S. Khalifa
Summary: The study evaluated the protective effect of kaempferol against cadmium chloride-induced liver damage through antioxidant and anti-inflammatory mechanisms, involving the upregulation of Nr12/HO-1 axis and suppression of NF-kappa B p65 and keap1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Orthopedics
Jia Wu, Haoliang Li, Fei Hu, Peng Luo
Summary: This study investigates the anti-inflammatory effects of Stevioside (STE) on osteoarthritis (OA) and its underlying mechanism. The findings suggest that STE can ameliorate OA development by inhibiting inflammation, potentially through the Nrf2/HO-1/NF-Kappa B signaling pathway. Treatment with STE also significantly reduces degeneration in the mouse destabilization of the medial meniscus (DMM) model.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Chemistry, Medicinal
Bin Zheng, Yakun Yang, Jinghan Li, Jing Li, Saijie Zuo, Xi Chu, Shan Xu, Donglai Ma, Li Chu
Summary: The study demonstrated that MgIG could significantly reduce ATO-induced cardiac toxicity through its anti-inflammation, anti-oxidation, and anti-apoptosis effects. Additionally, MgIG exerted its protective effects by modulating the Nrf2 pathway and suppressing the TLR4/NF-kappa B pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
