Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts

Transient Receptor Potential Vanilloid 4 channel participates in mouse ventricular electrical activity

(2021) Sebastien Chaigne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Transient Receptor Potential V4 Channels Mediate Lung Ischemia-Reperfusion Injury

(2021) Nathan Haywood et al.   ANNALS OF THORACIC SURGERY

TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching

(2020) Rachel G. Scheraga et al.   JOURNAL OF IMMUNOLOGY

CaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts

(2020) Hong-Ting Lu et al.   Cell Death & Disease

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

(2020) Brian M. Woolums et al.   Nature Communications

A review of myocardial ischaemia/reperfusion injury: Pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment

(2020) Mehmet Gunata et al.   CELL BIOCHEMISTRY AND FUNCTION

TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

(2020) Jonas Weber et al.   JCI Insight

JNK2, A Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca 2+ ] SR Leak-Load Relationship

(2020) JiaJie Yan et al.   CIRCULATION RESEARCH

TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats

(2020) Jie Liao et al.   JCI Insight

Pharmacological inhibition of TRPV4 channels protects against ischemia–reperfusion-induced renal insufficiency in neonatal pigs

(2019) Hitesh Soni et al.   CLINICAL SCIENCE

Blockade of Transient Receptor Potential Vanilloid 4 Enhances Antioxidation after Myocardial Ischemia/Reperfusion

(2019) Qiongfeng Wu et al.   Oxidative Medicine and Cellular Longevity

Propofol Induces Cardioprotection Against Ischemia-Reperfusion Injury via Suppression of Transient Receptor Potential Vanilloid 4 Channel

(2019) Binbin Wang et al.   Frontiers in Pharmacology

The effect of transient receptor potential vanilloid 4 on the intestinal epithelial barrier and human colonic cells was affected by tyrosine-phosphorylated claudin-7

(2019) Yuan-Yuan Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium

(2018) Xianlong Gao et al.   CARDIOVASCULAR RESEARCH

TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress

(2018) John L Jones et al.   CARDIOVASCULAR RESEARCH

Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia

(2018) Jiajie Yan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CaMKII is a nodal signal for multiple programmed cell death pathways in heart

(2017) Ning Feng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

(2017) James S. Lyons et al.   Science Signaling

Activation of transient receptor potential vanilloid 4 involves in hypoxia/reoxygenation injury in cardiomyocytes

(2017) Qiong-Feng Wu et al.   Cell Death & Disease

Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

(2017) James S. Lyons et al.   Science Signaling

MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels

(2017) Jin-zhuo Ning et al.   Frontiers in Physiology

Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice

(2017) Qian Dong et al.   Scientific Reports

Activation of Transient Receptor Potential Vanilloid 4 Promotes the Proliferation of Stem Cells in the Adult Hippocampal Dentate Gyrus

(2016) Yujing Tian et al.   MOLECULAR NEUROBIOLOGY

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

TRPV4: Molecular Conductor of a Diverse Orchestra

(2016) John P. M. White et al.   PHYSIOLOGICAL REVIEWS

Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning

(2015) G. Heusch   CIRCULATION RESEARCH

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy

(2015) R K Adapala et al.   ONCOGENE

Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways

(2015) P Jie et al.   Cell Death & Disease

Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice

(2014) Pinghui Jie et al.   MOLECULAR NEUROBIOLOGY

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

(2011) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

Determinants of TRPV4 Activity following Selective Activation by Small Molecule Agonist GSK1016790A

(2011) Min Jin et al.   PLoS One

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

(2008) Anthony J. Muslin   CLINICAL SCIENCE