Z-form extracellular DNA is a structural component of the bacterial biofilm matrix

The biofilm matrix scaffold of Pseudomonas aeruginosa contains G-quadruplex extracellular DNA structures

(2021) Thomas Seviour et al.   npj Biofilms and Microbiomes

The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection

(2020) Frank H. Robledo-Avila et al.   Frontiers in Immunology

The origin of extracellular DNA in bacterial biofilm infections in vivo

(2020) Maria Alhede et al.   Pathogens and Disease

Nontypeable Haemophilus influenzae Responds to Virus-Infected Cells with a Significant Increase in Type IV Pilus Expression

(2020) Elaine M. Mokrzan et al.   mSphere

Extracellular DNA Promotes Efficient Extracellular Electron Transfer by Pyocyanin in Pseudomonas aeruginosa Biofilms

(2020) Scott H. Saunders et al.   CELL

Topologically constrained formation of stable Z-DNA from normal sequence under physiological conditions

(2019) Yaping Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterizing Watson–Crick versus Hoogsteen Base Pairing in a DNA–Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA

(2019) Huiqing Zhou et al.   BIOCHEMISTRY

Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis

(2019) Tirthankar Mohanty et al.   Nature Communications

The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates

(2019) Aishwarya Devaraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the HUβ Protein Prevents Porphyromonas gingivalis from Entering into Preexisting Biofilms

(2018) Christopher J. Rocco et al.   JOURNAL OF BACTERIOLOGY

Unveiling the pathway to Z-DNA in the protein-induced B–Z transition

(2018) Sook Ho Kim et al.   NUCLEIC ACIDS RESEARCH

A Disintegrin and Metalloproteases (ADAMs) in Cardiovascular, Metabolic and Inflammatory Diseases: Aspects for Theranostic Approaches

(2018) Emiel van der Vorst et al.   THROMBOSIS AND HAEMOSTASIS

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

(2018) Teneema Kuriakose et al.   TRENDS IN IMMUNOLOGY

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

(2018) Bartosz Szczesny et al.   Scientific Reports

Viscoelastic properties of Pseudomonas aeruginosa variant biofilms

(2018) Erin S. Gloag et al.   Scientific Reports

Thermodynamic Model for B-Z Transition of DNA Induced by Z-DNA Binding Proteins

(2018) Ae-Ree Lee et al.   MOLECULES

Structural and evolutionary analyses reveal determinants of DNA binding specificities of nucleoid-associated proteins HU and IHF

(2017) Debayan Dey et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Targeting microbial biofilms: current and prospective therapeutic strategies

(2017) Hyun Koo et al.   NATURE REVIEWS MICROBIOLOGY

NontypeableHaemophilus influenzaereleases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery

(2017) Joseph A. Jurcisek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and Regulation of Extracellular DNA Release and Its Biological Roles in Microbial Communities

(2017) Alejandra L. Ibáñez de Aldecoa et al.   Frontiers in Microbiology

The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure

(2017) Aishwarya Devaraj et al.   MicrobiologyOpen

Z-DNA-forming sites identified by ChIP-Seq are associated with actively transcribed regions in the human genome

(2016) So-I. Shin et al.   DNA RESEARCH

Type IV Pilus Expression Is Upregulated in Nontypeable Haemophilus influenzae Biofilms Formed at the Temperature of the Human Nasopharynx

(2016) Elaine M. Mokrzan et al.   JOURNAL OF BACTERIOLOGY

What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention

(2016) John S. Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics

(2016) C.J. Rocco et al.   Molecular Oral Microbiology

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

Mechanical properties of DNA origami nanoassemblies are determined by Holliday junction mechanophores

(2016) Prakash Shrestha et al.   NUCLEIC ACIDS RESEARCH

Studying Z-DNA and B- to Z-DNA transitions using a cytosine analogue FRET-pair

(2016) Blaise Dumat et al.   NUCLEIC ACIDS RESEARCH

Escaping Underground Nets: Extracellular DNases Degrade Plant Extracellular Traps and Contribute to Virulence of the Plant Pathogenic Bacterium Ralstonia solanacearum

(2016) Tuan Minh Tran et al.   PLoS Pathogens

Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo

(2016) Laura A. Novotny et al.   EBioMedicine

Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases

(2015) M. A. A. Al-Bari   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

DNABII proteins play a central role in UPEC biofilm structure

(2015) Aishwarya Devaraj et al.   MOLECULAR MICROBIOLOGY

DNA recognition by Escherichia coli CbpA protein requires a conserved arginine–minor-groove interaction

(2015) Kiran Chintakayala et al.   NUCLEIC ACIDS RESEARCH

Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor

(2014) Markryan Dwyer et al.   Journal of Innate Immunity

Secreted single-stranded DNA is involved in the initial phase of biofilm formation byNeisseria gonorrhoeae

(2013) Maria Zweig et al.   ENVIRONMENTAL MICROBIOLOGY

Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein

(2013) Laura A. Novotny et al.   PLoS One

Microbial tribology and disruption of dental plaque bacterial biofilms

(2013) A. Rmaile et al.   WEAR

Influence of DNA on the Activities and Inhibition of Neutrophil Serine Proteases in Cystic Fibrosis Sputum

(2012) Alice V. Dubois et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epigenetic Regulation by Z-DNA Silencer Function Controls Cancer-Associated ADAM-12 Expression in Breast Cancer: Cross-talk between MeCP2 and NF1 Transcription Factor Family

(2012) B. K. Ray et al.   CANCER RESEARCH

Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis

(2012) Jodi E. Gustave et al.   Journal of Cystic Fibrosis

Direct and Real-Time Observation of Rotary Movement of a DNA Nanomechanical Device

(2012) Arivazhagan Rajendran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Methylation in the Intrinsic Dynamics of B- and Z-DNA

(2012) Nuri A. Temiz et al.   PLoS One

Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization

(2012) Laura A. Novotny et al.   VACCINE

Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci

(2011) Jeffrey B Kaplan et al.   JOURNAL OF ANTIBIOTICS

Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae

(2011) L A Novotny et al.   Mucosal Immunology

Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins

(2011) S D Goodman et al.   Mucosal Immunology

Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms

(2011) Margarida Martins et al.   MYCOSES

Alternate rRNA secondary structures as regulators of translation

(2011) Shu Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Excess histone levels mediate cytotoxicity via multiple mechanisms

(2010) Rakesh Kumar Singh et al.   CELL CYCLE

Intrinsic Z-DNA Is Stabilized by the Conformational Selection Mechanism of Z-DNA-Binding Proteins

(2010) Sangsu Bae et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator

(2010) Lauren Mashburn-Warren et al.   MOLECULAR MICROBIOLOGY

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Comparative analyses of distributions and functions of Z-DNA in Arabidopsis and rice

(2009) Chan Zhou et al.   GENOMICS

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates

(2008) Luanne Hall-Stoodley et al.   BMC MICROBIOLOGY

Utilization of an Intracellular Bacterial Community Pathway in Klebsiella pneumoniae Urinary Tract Infection and the Effects of FimK on Type 1 Pilus Expression

(2008) D. A. Rosen et al.   INFECTION AND IMMUNITY