期刊
CARBOHYDRATE POLYMERS
卷 269, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118272
关键词
PVA; Methacrylate kappa-carrageenan; Chitooligosaccharide; Hydrogel wound dressing; Wound healing
资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019R1A2C1007218, 2021R1A6A1A03039211]
- National Research Foundation of Korea [2021R1A6A1A03039211, 2019R1A2C1007218] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study successfully developed a composite hydrogel wound dressing, Pic-CaC, with promising properties for wound healing. The hydrogel showed excellent mechanical stability, biocompatibility, and wound healing capabilities, indicating its potential application as a wound dressing.
To develop an effective and mechanically robust wound dressing, a poly (vinyl alcohol) (PVA)/methacrylate kappa-carrageenan (ic-CaMA) composite hydrogel encapsulated with a chitooligosaccharide (COS) was prepared in a cassette via repeated freeze/thaw cycles, photo-crosslinking, and chemical cross-linking. The chemical, physical, mechanical, in vitro biocompatibility, in vivo wound-healing properties, and antibacterial activity of triple-crosslinked hydrogel were subsequently characterized. The results showed that the PVA/ic-CaMA/COS (PicCaC) hydrogel had a uniformly thick, highly porous three-dimensional architecture with uniformly distributed pores, a high fluid absorption, and retention capacity without disturbing its mechanical stability, and good in vitro biocompatibility. Macroscopic images from the full-thickness skin wound model revealed that the wounds dressed with the proposed Pic-CaC hydrogel were completely healed by day 14, while the histomorphological results confirmed full re-epithelization and rapid skin-tissue remodeling. This study thus indicates that the composite Pic-CaC hydrogel has significant potential for use as a wound dressing.
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