Article
Engineering, Biomedical
Zhaoyuan Guo, Zhuangzhuang Zhang, Nan Zhang, Wenxia Gao, Jing Li, Yuji Pu, Bin He, Jing Xie
Summary: In this study, a composite antibacterial hydrogel PDA-PAM/Mg2+ was developed for accelerated wound healing. This hydrogel showed excellent self-healing and tissue adhesive properties, as well as photothermal antibacterial functions. It demonstrated efficient bacteria inhibition and enhanced wound healing in a rat model.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jialu Qiao, Yongchao Jiang, Zhitao Ren, Keyong Tang
Summary: Due to antibiotic misuse and the increase in drug-resistant bacteria, it is crucial to develop new antibacterial strategies for treating infected wounds. In this study, stable tricomplex molecules (PA@Fe) were synthesized by combining protocatechualdehyde (PA) and ferric iron (Fe), and embedded in a gelatin matrix to create Gel-PA@Fe hydrogels. The embedded PA@Fe acted as a crosslinker, improving the mechanical, adhesive, and antioxidant properties of the hydrogels through coordination and dynamic Schiff base bonds. It also functioned as a photothermal agent, effectively killing bacteria by converting near-infrared (NIR) light into heat. In vivo evaluation using an infected full-thickness skin wound mice model demonstrated that Gel-PA@Fe hydrogels promoted collagen deposition and accelerated wound closure, indicating their potential in enhancing the healing process of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yikun Ren, Shanshan Ma, Dan Zhang, Shen Guo, Rong Chang, Yuanmeng He, Minghao Yao, Fangxia Guan
Summary: An injectable hyaluronic acid hydrogel with antioxidative and photothermal antibacterial activity has been developed as a functional dressing for infected wounds. This hydrogel demonstrates good stability, biocompatibility, and effective prevention of early infection and acceleration of wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Yuanmeng He, Kaiyue Liu, Shen Guo, Rong Chang, Chen Zhang, Fangxia Guan, Minghao Yao
Summary: A multifunctional hydrogel (OGF) based on oxidized dextran, gallic acid-grafted gelatin, and Ferric ion showed excellent antibacterial ability and promoted the healing of infected wounds in diabetic patients.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Shuang Cheng, Meng Pan, Danrong Hu, Ruxia Han, Lang Li, Zhongwu Bei, Yicong Li, Ao Sun, Zhiyong Qian
Summary: Photothermal antibacterial technology is a promising strategy for treating bacterial wound infections. The study developed a multifunctional hydrogel that combines inherent antibacterial activity and light-assisted antibacterial treatment. The hydrogel showed excellent antibacterial properties, efficient wound healing, and low toxicity to cells.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Environmental
Jia Li, Yanjie Wang, Jianhai Yang, Wenguang Liu
Summary: A novel multifunctional nanocomposite antibacterial hydrogel with high strength and toughness has been successfully prepared, which can specifically recognize the source bacteria and kill 98% of bacteria. This hydrogel implanted in rats can promote the healing of infected wounds and avoid secondary damage.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Yuanchun Du, Zekai Liu, Qingxin Yang, Deshuai Zhen, Yu Liu, Guangfu Feng
Summary: This study reports an innovative technique for acquiring the programmed temperature by managing the catalytic activity of nanozymes. The technique shows high-efficiency antibacterial effects against two common bacteria in vitro and effectively promotes wound healing in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Meng Li, Yongping Liang, Yuqing Liang, Guoying Pan, Baolin Guo
Summary: Researchers have developed an injectable adhesive self-healing photothermal hydrogel that can adapt to frequent movement wounds and promote healing, while also preventing and treating wound infections.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Yunhao Yu, Rui Tian, Yu Zhao, Xudong Qin, Liefeng Hu, Jun-Jie Zou, Ying-Wei Yang, Jian Tian
Summary: Microvascular dysfunction caused by hyperglycemia leads to slow healing of diabetic wounds and increases the risk of bacterial infection. This study developed novel supramolecular photothermal nanoparticles for treating bacterial wound infection, which demonstrated potent photothermal and antimicrobial effects, as well as good biocompatibility. The nanoparticles showed selective targeting towards bacteria and were effective against drug-resistant strains. Overall, this research represents a promising photothermal antibacterial nanoplatform.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Rong Chang, Donghui Zhao, Chen Zhang, Kaiyue Liu, Yuanmeng He, Fangxia Guan, Minghao Yao
Summary: In this study, an enzyme-crosslinked hyaluronic acid-tyramine (HT) hydrogel loaded with antioxidant and photothermal silver nanoparticles (AgNPs), named HTA, was developed as a functional wound dressing to promote the healing of infected skin wounds. The incorporation of AgNPs significantly enhanced the antioxidant, antibacterial, photothermal antibacterial, adhesive, and hemostatic abilities of the HTA hydrogel. In vivo results showed that HTA hydrogel combined with near infrared ray radiation alleviated inflammation, promoted angiogenesis, and accelerated the healing process of co-infected mouse skin wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Puxiang Zhao, Yue Feng, Youquan Zhou, Cuiying Tan, Mingxian Liu
Summary: In this study, a wound healing hydrogel dressing with halloysite clay and chitin as the main components was prepared. The antibacterial properties, biocompatibility, and hemostatic properties of the hydrogel material were investigated. The results showed that the composite hydrogel exhibited excellent antibacterial and hemostatic activities, promoted wound healing, and had low cytotoxicity.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Ge Xie, Xiao Wang, Min Mo, Lianbin Zhang, Jintao Zhu
Summary: Photothermal hydrogels, as an important platform for photothermal therapies, have shown promising prospects in the field of infected wound treatments. This review summarizes the progress, challenges, and prospects of photothermal hydrogels in promoting infected wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Kaiyue Liu, Chen Zhang, Rong Chang, Yuanmeng He, Fangxia Guan, Minghao Yao
Summary: In this study, a multifunctional PBOF hydrogel was designed, with ultra-stretchability, high tissue adhesion, rapid adaptability, and self-healing ability. It can be used for treating infected skin wounds, with antioxidant, antibacterial, and hemostatic capabilities, to accelerate wound healing.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Peng Zhao, Yu Zhang, Xiaoai Chen, Chang Xu, Jingzhe Guo, Meigui Deng, Xiongwei Qu, Pingsheng Huang, Zujian Feng, Jimin Zhang
Summary: Bacterial infection often leads to chronic wound healing due to increased inflammation. A versatile hydrogel dressing (rGB/QCS/PDA-PAM) with skin adaptiveness and mild photothermal antibacterial activity is developed for effective treatment of infected wounds. This hydrogel dressing has considerable potential in treating wounds infected with drug-resistant bacteria.
Article
Cardiac & Cardiovascular Systems
Dongze Li, Yisong Cheng, Jing Yu, Yu Jia, Fanghui Li, Qin Zhang, Xiaoli Chen, Yongli Gao, Jiang Wu, Lei Ye, Zhi Wan, Yu Cao, Rui Zeng
Summary: The study developed and validated a simple physiological prognostic scoring system for early risk stratification in patients with acute myocardial infarction. The system showed superior performance compared to existing risk scoring systems, making it a useful tool for assessing patients with acute myocardial infarction.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Urology & Nephrology
Yichun Cheng, Nanhui Zhang, Ran Luo, Meng Zhang, Zhixiang Wang, Lei Dong, Junhua Li, Rui Zeng, Ying Yao, Shuwang Ge, Gang Xu
Summary: The study found a high incidence of acute kidney injury in COVID-19 patients, with severe AKI being associated with high in-hospital mortality. Inflammatory response may play a role in the development of AKI in critically ill patients with COVID-19.
Article
Chemistry, Physical
Ruijin Zeng, Weijun Wang, Mingming Chen, Qing Wan, Caicheng Wang, Dietmar Knopp, Dianping Tang
Summary: This study introduces a CRISPR-Cas12a-based instrument-free point-of-care detection technology, which uses smartphone for visualized DNA detection results, and combines wireless sensing technology, significantly improving portability and detection sensitivity.
Article
Engineering, Environmental
Jin-Shuai Lan, Rui-Feng Zeng, Yu Wang, Lu Zhen, Yun Liu, Rodney J. Y. Ho, Yue Ding, Tong Zhang
Summary: A fluorescent probe based on intramolecular charge transfer was developed for the detection of SO2 derivatives, allowing for accurate quantification, real-time monitoring, and bioimaging of SO32-/HSO3-.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xuan Deng, Cheng Zhou, Ruichun Liao, Yi Guo, Yuxi Wang, Guoli Li, Jianliang Wu, Huzi Xu, Zhizhi Hu, Guangchang Pei, Wenhui Liao, Ying Yao, Qian Yang, Rui Zeng, Gang Xu
Summary: This study found that different immune cells have varying lifespans in the kidney, which may play distinct roles during the progression from AKI to CKD.
Article
Oncology
Huai-yu Wang, Suyuan Peng, Zhanghui Ye, Pengfei Li, Qing Li, Xuanyu Shi, Rui Zeng, Ying Yao, Fan He, Junhua Li, Liu Liu, Shuwang Ge, Xianjun Ke, Zhibin Zhou, Gang Xu, Ming-hui Zhao, Haibo Wang, Luxia Zhang, Erdan Dong
Summary: The study found that the use of RAS-I and ARB in COVID-19 patients can reduce the risk of all-cause mortality, especially for patients with hypertension.
FRONTIERS OF MEDICINE
(2022)
Article
Polymer Science
Xinyi Luo, Kunlun Zhang, Ruiming Zeng, Ying Chen, Li Zhang, Jianbo Tan
Summary: A novel difunctional RAFT agent with an asymmetric structure was synthesized and used to prepare segmented macro-RAFT agents, leading to the formation of segmented copolymers with different blocks. Introduction of a certain number of trithiocarbonate groups on the surface of block copolymer nano-objects was achieved, providing a platform for further chain extension and functionalization. This study not only provides important mechanistic insights into RAFT polymerization mediated by multifunctional RAFT agents but also enables the preparation of functional block copolymer nano-objects.
Article
Chemistry, Medicinal
Guanlan Chen, Rui Zeng, Xin Wang, Hongying Cai, Jiajia Chen, Yingxiong Zhong, Saiyi Zhong, Xuejing Jia
Summary: Clam heparinoid G2 and its depolymerized derivatives DG1 and DG2 have shown excellent fibrinolytic and anticoagulant activity. Results indicate that G2 has a high anticoagulant effect, while DG2 has a greater thrombolytic activity. Furthermore, oral administration of DG1 reduces thrombus formation, increases tissue-type plasminogen activator levels, and improves changes in intestinal bacteria. These findings suggest that DG1 could be an oral agent with antithrombotic properties.
Article
Medicine, General & Internal
R. Zeng, H. Wu, X. Qiu, Z. Zhuo, W. Sha, H. Chen
Summary: This study developed an effective prognostic signature for predicting colorectal cancer (CRC) by evaluating the signal transducer and activator of transcription (STAT) signaling. The signature was significantly associated with CRC survival and correlated with the tumor immune microenvironment. The hub gene Caveolin-1 (CAV1) within the signature was found to inhibit cell proliferation, induce apoptosis and senescence, and suppress tumor angiogenesis in CRC. This research highlights the importance of the STAT regulator CAV1 and suggests that modulating STAT and its regulators could be a promising strategy for CRC in clinical practice.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Barbara Santos, Rui Zeng, Sasa F. Jorge, Jose Ribamar Ferreira-Junior, Antoni Barrientos, Mario H. Barros
Summary: Mitoribosomes in Saccharomyces cerevisiae consist of a 54S large subunit and a 37S small subunit, containing a total of 73 mitoribosome proteins and two ribosomal RNAs. These proteins have adapted by acquiring new proteins, extensions, and RNA segments, to synthesize highly hydrophobic membrane proteins. The study investigates the functional relevance of mitochondria-specific protein extensions in the mtLSU, revealing their importance in mitochondrial protein synthesis capacities and rRNAs interactions.
Review
Multidisciplinary Sciences
Ruijie Zeng, Zewei Zhuo, Yujun Luo, Weihong Sha, Hao Chen
Summary: Rho GTPases play crucial roles in the pathogenesis of various rheumatic diseases, promoting disease progression through activation of downstream pathways. Therapeutic strategies using Rho GTPase inhibitors have shown promising effects in the treatment of rheumatic diseases. Future studies should focus on further exploring the role of Rho GTPases in rheumatic diseases based on current understandings.
Article
Environmental Sciences
Tianfang Xu, Qianqiu Longyang, Conor Tyson, Ruijie Zeng, Bethany T. Neilson
Summary: This study presents a hybrid modeling approach that combines a physically based snow model with a deep learning karst model to predict streamflow in mountainous karst watersheds. The approach is tested on a watershed in northern Utah and shows high accuracy in simulating streamflow. The deep learning model captures the spatiotemporal recharge and discharge patterns and provides valuable insights into hydrologic responses influenced by complex surface and subsurface properties.
WATER RESOURCES RESEARCH
(2022)
Review
Medicine, General & Internal
Chujin Cao, Han Zhu, Ying Yao, Rui Zeng
Summary: Gut dysbiosis is a major mechanism in the development of kidney diseases, and improving the gut microbiota can potentially slow down the progression of kidney diseases.
FRONTIERS IN MEDICINE
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Zixin Peng, Genglin Zhu, Mu Li, Ruifeng Zeng, Sibo Cheng, Kaisheng Wang
Summary: This paper investigates how to balance the safety and cost-effectiveness of UAVs in fighting forest fires. Through a case study, the particle swarm algorithm, topology spanning tree algorithm, and ant colony algorithm are used to optimize the patrol paths and minimize the cost of the drones.
2ND INTERNATIONAL CONFERENCE ON APPLIED MATHEMATICS, MODELLING, AND INTELLIGENT COMPUTING (CAMMIC 2022)
(2022)
Article
Plant Sciences
Dong Wang, Rui Zeng, Zhixin Hu, Xiang Li, Yuan Guo, Pan Yang, Wei She, Wanli Kang
Summary: The study demonstrated that planting kenaf and ramie on gentle slopes in eastern Hunan can help with water and soil conservation, as well as prevent soil erosion, while also providing economic benefits.
BANGLADESH JOURNAL OF BOTANY
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
