Article
Mechanics
Matthew D. Butler, Thomas D. Montenegro-Johnson
Summary: Thermo-responsive hydrogels exhibit significant expansion and contraction in response to temperature changes, making them promising materials for controllable actuators in micro-scale devices. By studying these systems using a poro-elastic model, we can better understand the dynamic properties and different swelling and shrinking behaviors of thermo-responsive hydrogels.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Engineering, Biomedical
Menekse Ermis, Natashya Falcone, Natan Roberto De Barros, Marvin Mecwan, Reihaneh Haghniaz, Auveen Choroomi, Mahsa Monirizad, Yeji Lee, Jihyeon Song, Hyun-Jong Cho, Yangzhi Zhu, Heemin Kang, Mehmet R. Dokmeci, Ali Khademhosseini, Junmin Lee, Han -Jun Kim
Summary: The tumor microenvironment, particularly the matrix component, plays a crucial role in the progression and therapeutic responsiveness of PDAC. By engineering hyaluronic acid and gelatin-based hydrogels to mimic desmoplastic matrices, a multicellular pancreatic tumor model is developed that allows for a better understanding and monitoring of PDAC progression, with potential applications in personalized medicine and drug testing.
BIOACTIVE MATERIALS
(2023)
Review
Engineering, Manufacturing
Mahdiyar Shahbazi, Henry Jaeger, Rammile Ettelaie, Adeleh Mohammadi, Peyman Asghartabar Kashi
Summary: 3D printing and 4D printing techniques have great potential in additive manufacturing of functional and architected materials, relying on the improvement of printable polymeric inks. Understanding thermoresponsive polymers (TRPs) can lead to design of new feedstocks and compatibility with fabrication processes. This review provides an overview of functional design, different classes, and applications of TRPs in 3D printing, as well as basic knowledge of gelation mechanisms, bio-based adsorption, adhesion, and fabrication strategies.
ADDITIVE MANUFACTURING
(2023)
Article
Pharmacology & Pharmacy
Elif Gulin Ertugral-Samgar, Ali Murad Ozmen, Ozgul Gok
Summary: Injectable biomaterials, specifically temperature-responsive hydrogel scaffolds with embedded targeted nanoparticles, have been utilized in controlled drug delivery. The engineered hydrogel network showed slower drug release compared to free nanoparticles, with high water uptake capacity and mechanical stability. The therapy has the potential to specifically target tumor tissues and can be used as a post-operative drug delivery system for tumor resection.
Article
Pharmacology & Pharmacy
Snezana Ilic-Stojanovic, Ljubisa Nikolic, Vesna Nikolic, Slobodan Petrovic, Violeta Oro, Zarko Mitic, Stevo Najman
Summary: Hydrogels were synthesized using free radical initiated copolymerization, with different cross-linker concentrations. The structures and properties of the hydrogels were confirmed using various analysis methods. The study focused on swelling behavior, drug release, and evaluated the potential of hydrogels as drug carriers.
Article
Polymer Science
Xin Fan, Xiong Liu, Fangfei Liu, Haibin Gu
Summary: Hydrogels with stimuli-responsive behavior, including temperature and beta-cyclodextrin responsiveness, were prepared using Grubbs' catalyst as the initiator. The presence of ferrocenecontaining monomers and hydrophilic norbornene monomers played crucial roles in maintaining the structure and enhancing the physical strength of the hydrogels. The hydrogels also exhibited responsive behavior to beta-CD solution due to the host-guest interaction. This study provides a new idea for the design of smart hydrogels.
Article
Polymer Science
Jiarong Wang, Mingyu Guo
Summary: Thermo-responsive supramolecular hydrogels with good mechanical properties were synthesized by grafting poly(N-isopropylacrylamide) (PNIPAm) onto a polyurethane-urea (PUU) copolymer. In addition, temperature-responsive and mechanically strong 3D hydrogel scaffolds were developed using 3D printing technique. These materials have potential applications in cell sheet culture.
Article
Materials Science, Multidisciplinary
Shuaiwei Yuan, Tianwen Dai, Xinyue Jiang, Huawei Zou, Pengbo Liu
Summary: By constructing a semi-IPN structure, a transparent hydrogel with EMI shielding performance and good mechanical properties was fabricated. The addition of lithium chloride improved the dehydration resistance and flexibility of the hydrogel, and it also exhibited attractive electrical conductivity.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Polymer Science
Kaiwen Zhang, Kun Xue, Xian Jun Loh
Summary: Thermogels, also known as thermo-sensitive hydrogels, exhibit sol-gel transition with increasing temperature and are injectable yet can form in situ gel in the human body. They serve as a useful platform biomaterial operating at physiological body temperatures. Research on thermogels has shown diverse applications in drug delivery, 3D cell culture, and tissue engineering.
Article
Polymer Science
Chuxiang Zhou, Shuaiwei Yuan, Tianwen Dai, Shengtai Zhou, Huawei Zou, Pengbo Liu
Summary: A mechanically robust hydrogel containing LiCl, PAM, PVA, and GO was fabricated and evaluated for its properties. The hydrogel exhibited excellent water retention, compressive recovery, and EMI shielding performance.
Article
Chemistry, Applied
Ilayda Tarhanli, Erkan Senses
Summary: A thermo-responsive nanocomposite system is constructed using cellulose nanocrystals and sodium polypyrrole-sulfonate. By adjusting the concentration of the sodium polypyrrole-sulfonate, the mechanical properties of the nanocrystal network can be altered. At low concentrations, the composite system becomes softer but more fragile. However, at high concentrations, the system becomes stronger and forms a gel network. Additionally, the gelation temperature of the nanocomposite hydrogels can be tuned by increasing the concentration of sodium polypyrrole-sulfonate.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Zirong Xu, Kelin Wu, Huayong Luo, Qin Wang, Tian C. Zhang, Xiaobing Chen, Hongwei Rong, Qian Fang
Summary: An electro-responsive hydrogel with semi-interpenetrating polymer networks was explored, showing enhanced swelling capacity and dewatering effects, with potential for improving forward osmosis performance.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Bingyan Hua, Hongliang Wei, Chunwang Hu, Yaqi Zhang, Shuai Yang, Gang Wang, Tao Guo, Jingjing Li
Summary: A semi-interpenetrating network hydrogel (SH/PNA) was prepared using simple free radical polymerization methods and filled with sodium alginate and humic acid. The structure and properties were characterized using various analytical techniques. The hydrogel exhibited excellent water absorption capacity and pH/temperature dual responsiveness.
Review
Engineering, Biomedical
Pei Zhuang, Yi-Hua Chiang, Maria Serafim Fernanda, Mei He
Summary: Although cancer remains a leading cause of mortality worldwide, efforts in anticancer therapeutics are hindered by the lack of robust prediction models. Multicellular tumor spheroids, a popular three-dimensional culture model for avascular tumors, have limitations in controlling cellular and structural organization. 3D bioprinting, with its spatial control, scalability, and reproducibility, holds promise for generating more faithful tumor models and advancing our understanding of tumor progression.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Materials Science, Multidisciplinary
Supissra Boon-in, Man Theerasilp, Daniel Crespy
Summary: Skin inflammation can cause an increase in skin temperature, and cooling inflamed skin can relieve pain and dissipate heat. Evaporative cooling hydrogels with high latent heat are promising materials for flexible dressings. A double-network hydrogel formed with PAMPS and PNIPAM can release water above the skin temperature and delay the release of water, resulting in prolonged cooling performance and enhanced mechanical properties. Our material demonstrates superior cooling power with lower temperature compared to other reported hydrogels for passive cooling, and it can be applied to cool other structures such as photovoltaic panels or roofs of buildings.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Afonso Malheiro, Maria Thon, Ana Filipa Lourenco, Adrian Seijas Gamardo, Amit Chandrakar, Susan Gibbs, Paul Wieringa, Lorenzo Moroni
Summary: By deriving nociceptor neurospheres from induced pluripotent stem cells, a functional in vitro human skin model with a sensory neuron population is established. The model exhibits similar morphological and phenotypical characteristics to native skin, and the neurons innervate the artificial skin. The reaction of the neurons is analyzed by applying a clinically available capsaicin patch, showing the potential of this model for preclinical research.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Green & Sustainable Science & Technology
F. Scalera, S. I. A. Pereira, A. Bucciarelli, D. M. Tobaldi, A. Quarta, F. Gervaso, P. M. L. Castro, A. Polini, C. Piccirillo
Summary: Chitosan (Cs) and hydroxyapatite (HA) 3D scaffolds/composites were prepared using a sustainable process, with HA obtained from cork-derived CaCO3 acting as a template agent. HA@Cs composites were formed by in situ HA formation in a Cs solution. The CsHA_72 composite exhibited improved pore structure, smaller and more circular pores, excellent biocompatibility, and good cell proliferation, making it a suitable biomaterial.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Chemistry, Multidisciplinary
Shahzad Hafeez, Ana A. Aldana, Hans Duimel, Floor A. A. Ruiter, Monize Caiado Decarli, Vanessa Lapointe, Clemens van Blitterswijk, Lorenzo Moroni, Matthew B. Baker
Summary: Traditional synthetic covalent hydrogels lack the native tissue dynamics and hierarchical fibrous structure found in the extracellular matrix (ECM). Here, the molecular tuning of a supramolecular benzene-1,3,5-tricarboxamide (BTA) hydrogelator via simple modulation of hydrophobic substituents is reported. These hydrogels show high cell viability for chondrocytes and human mesenchymal stem cells, establishing their use in tissue engineering applications.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Melissa Schepers, Afonso Malheiro, Adrian Seijas Gamardo, Niels Hellings, Jos Prickaerts, Lorenzo Moroni, Tim Vanmierlo, Paul Wieringa
Summary: Phosphodiesterase 4 (PDE4) inhibitors, such as roflumilast, have been extensively studied for their anti-inflammatory and neuroregenerative properties. This study found that roflumilast can promote differentiation of Schwann cells and accelerate myelination, as demonstrated in vitro using rat cells and a 3D co-culture model. These findings contribute to the development of PDE4 inhibition-based therapies in peripheral regenerative medicine.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Fabiana Amiri, Emanuela Bologna, Gianmarco Nuzzo, Lorenzo Moroni, Massimiliano Zingales
Summary: This paper presents a three-axial model of linear hereditariness and fractional-order calculus to describe the constitutive behavior of fibrous tissues like the meniscus. It also introduces a novel model of fractional-order poromechanics to study the evolution of diffusion phenomenon in the meniscus. A numerical application involving a 1D confined compression test is conducted to demonstrate the influence of material hereditariness on pressure drop evolution.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Rong Wang, Febriyani Damanik, Tobias Kuhnt, Armand Jaminon, Shahzad Hafeez, Hong Liu, Hans Ippel, Pieter J. Dijkstra, Nicole Bouvy, Leon Schurgers, A. Tessa ten Cate, Aylvin Dias, Lorenzo Moroni, Matthew B. Baker
Summary: Digital Light Processing (DLP) is a precise and fast additive manufacturing technique used for producing various products. However, the lack of biodegradable resin development has hindered its use in tissue engineering. This study investigates a library of biodegradable poly(esters) capped with urethane acrylate as printable resins for tissue engineering. The synthesized oligomers show good printability and are capable of creating complex structures with mechanical moduli close to medium-soft tissues.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Claudia Del Toro Runzer, Shivesh Anand, Carlos Mota, Lorenzo Moroni, Christian Plank, Martijn van Griensven, Elizabeth R. Balmayor
Summary: Nucleic acids have great potential for gene therapy, with plasmid DNA as the first therapeutic nucleic acid and mRNA as a safer and more affordable option. This study investigated the uptake mechanisms and efficiencies of genetic material by cells, focusing on different nucleic acids, delivery vectors, and human primary cells. The study found that caveolae-mediated uptake was the main route for gene delivery, pDNA had higher expression levels in fast-dividing fibroblasts, cmRNA was responsible for high protein production in slow-dividing osteoblasts, and in mesenchymal stem cells, the combination of vector and nucleic acid was more relevant. Protein expression was higher when cells were seeded on 3D scaffolds.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Polymer Science
Giulia Morello, Gianvito De Iaco, Giuseppe Gigli, Alessandro Polini, Francesca Gervaso
Summary: Hydrogels are biomaterials that can act as a scaffold for cells to organize themselves spatially, similar to what occurs in vivo. They are essential for the development of 3D systems and can recreate the cellular microenvironment, making them ideal for tissue engineering and 3D in vitro modeling.
Article
Chemistry, Multidisciplinary
Shahzad Hafeez, Monize Caiado Decarli, Agustina Aldana, Mahsa Ebrahimi, Floor A. A. Ruiter, Hans Duimel, Clemens van Blitterswijk, Louis M. Pitet, Lorenzo Moroni, Matthew B. Baker
Summary: This article investigates a synthetic supramolecular/covalent strategy for creating a tough hydrogel with the hierarchical fibrous architecture of the extracellular matrix (ECM). The hydrogelator self-assembles to form a viscoelastic hydrogel and is reinforced by covalent intra- and interfiber cross-links, resulting in enhanced mechanical properties. The hydrogels exhibit high tensile strain and compressive strain, are shear-thinning, and can be 3D bioprinted. Additionally, the hydrogels enable the bioprinting and differentiation of human mesenchymal stromal cell (hMSC) spheroids into chondrogenic tissue.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Mariana I. Neves, Mariana Magalhaes, Silvia J. Bidarra, Lorenzo Moroni, Cristina C. Barrias
Summary: This study explored the use of a biocompatible and bio-orthogonal click chemistry reaction to graft cyclooctyne-modified alginate with bi-azide-functionalized PVGLIG peptides, creating artificial extracellular matrices for tissue engineering applications.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Mahtab Asadian, Clarissa Tomasina, Yuliia Onyshchenko, Ke Vin Chan, Mohammad Norouzi, Jip Zonderland, Sandra Camarero-Espinosa, Rino Morent, Nathalie De Geyter, Lorenzo Moroni
Summary: This study investigates the effect of different surface properties induced by surface modifications on bone marrow-derived mesenchymal stromal cells (BMSCs) chondrogenic behavior. The results show that surface modifications can modulate the chondrogenic differentiation of BMSCs, and carboxylated nanofibers promote chondrogenesis.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Engineering, Biomedical
Zhengbo Wen, Yuxin Chen, Peilin Liao, Fengyu Wang, Weiping Zeng, Shoupei Liu, Haibing Wu, Ning Wang, Lorenzo Moroni, Minmin Zhang, Yuyou Duan, Honglin Chen
Summary: In this study, an in situ cell electrospinning system was developed as an attractive approach for stem cell delivery, which could promote cutaneous wound healing through direct deposition of bioactive fish gelatin fibers and MSCs onto wound sites, leading to a synergistic therapeutic effect.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Endocrinology & Metabolism
Marta Nazzari, Mirian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Summary: This study demonstrates that despite a limited number of differentially expressed genes, various analysis methods can be used to obtain relevant information on phthalates, highlighting the potential of in vitro thyroid-related systems for the analysis of endocrine disruptors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Materials Science, Biomaterials
Antonio J. Feliciano, Eduardo Soares, Anton W. Bosman, Clemens van Blitterswijk, Lorenzo Moroni, Vanessa L. S. LaPointe, Matthew B. Baker
Summary: The ability to utilize directional supramolecular interactions to anchor an antifouling coating to a polymer surface containing a complementary supramolecular unit was investigated. By adjusting the UPy composition, the antifouling properties and lifespan of the coating were controlled. Surface modification employing supramolecular interactions provided an approach that combines the simplicity and scalability of nonspecific coating methodology with the specific anchoring capacity found when using conventional covalent grafting with longevity that could be engineered by the supramolecular composition itself.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Biomaterials
Julia Fernandez-Perez, Kenny A. A. van Kampen, Carlos Mota, Matthew Baker, Lorenzo Moroni
Summary: Coronary artery disease affects millions worldwide. Off-the-shelf grafts are needed for bypass surgeries, and this study describes the fabrication of tubular scaffolds using melt spinning. The scaffolds showed good performance in bending tests, no leakage when liquid was passed through, and successful suturing of native arteries. Mesenchymal stromal cells seeded on the scaffolds differentiated into vascular smooth muscle-like cells, and endothelial cells formed a tightly packed monolayer. These ECM-mimicking scaffolds have great potential for use as vascular conduits in vivo.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
