Review
Biochemistry & Molecular Biology
Shuai Zhang, Mingxu Zhang, Wei Li, Lina Ma, Xinglong Liu, Qiteng Ding, Weimin Yu, Taojing Yu, Chuanbo Ding, Wencong Liu
Summary: Natural plant polysaccharides have a wide range of biological activities, especially in the treatment of inflammatory bowel disease. Their molecular weight, composition of monosaccharides, and connection of glycosidic bonds will affect the therapeutic effect. Traditional Chinese medicine plant polysaccharides and other types of plant polysaccharides can alleviate colitis by regulating inflammatory cytokine levels, signaling pathways, and intestinal flora balance, providing a theoretical basis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Zhong Wu, Wenzhi Zeng, Xun Zhang, Jiangfan Yang
Summary: A bioactive acidic tea polysaccharide was extracted from yellow leaves of Wuyi rock tea. The main glycosidic bonds were identified using nuclear magnetic resonance analysis. The polysaccharide showed hypoglycemic effects and improved lipid metabolism and intestinal flora in hyperglycemic rats.
Article
Biochemistry & Molecular Biology
Mengze Zhou, Jingke Zhi, Jiayi Zhi, Zhenghan Xiong, Fan Wu, Yuanyuan Lu, Qinghua Hu
Summary: Sea urchin eggs, known as a popular food, have been found to exhibit immunomodulatory activities and potential therapeutic effects on inflammatory bowel disease (IBD). This study demonstrated that polysaccharides from Strongylocentrotus nudus eggs (SEP) can effectively inhibit dextran sodium sulfate-induced ulcerative colitis in mice. SEP treatment resulted in improvement of disease symptoms, restoration of gut barrier function, and modulation of intestinal flora. Mechanistically, SEP was shown to regulate autophagy-related factors in intestinal epithelial cells (IECs) through the PI3K/Akt pathway. The expression of the CD36 receptor was found to be significant in mediating these effects. Overall, this study suggests that SEP could be used as a prebiotic agent for the management of IBD through its regulation of IEC autophagy via the CD36-PI3K/Akt pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Food Science & Technology
Qi Li, Linyan Li, Qiqiong Li, Junqiao Wang, Shaoping Nie, Mingyong Xie
Summary: The incidence of inflammatory bowel disease (IBD) is increasing, and there is a need for safe and effective treatment methods. Natural polysaccharides (NPs) have attracted attention for their efficiency, low toxicity, and wide range of biological activities in treating IBD. This paper focuses on exploring the beneficial effects of NPs on IBD, with a special focus on the role of intestinal microbiota.
Review
Nutrition & Dietetics
Yang Ye, Yanan Liu, Kejun Cheng, Zufang Wu, Peng Zhang, Xin Zhang
Summary: Research on intestinal flora has become extremely important in clinical medicine and life science. Irritable bowel syndrome is a common disease with unknown pathogenic mechanisms. The gut-brain axis plays a crucial role in preventing irritable bowel syndrome.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Yikun Wang, Haibin Zhu, Xiaoji Wang, Yue Yu, Jianhua Xie
Summary: Natural polysaccharides and their metabolites, particularly short chain fatty acids (SCFAs), have shown promising potential in attenuating systemic inflammation, especially in the context of inflammatory bowel disease (IBD). Recent studies have highlighted the various mechanisms through which natural polysaccharides can impact IBD, including regulating intestinal microbiota ratios, modulating immune cytokines levels, and enhancing intestinal integrity. These effects contribute to reducing inflammation, improving intestinal health, and reducing the risk of IBD.
Review
Pharmacology & Pharmacy
Dulce C. Macias-Ceja, Maria D. Barrachina, Dolores Ortiz-Masia
Summary: Chronic inflammation is associated with excessive deposition of extracellular matrix and leads to fibrosis. Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD), and deregulated autophagy is linked to fibrosis progression. Understanding the role of autophagy in fibrosis may provide new targets for antifibrotic therapy. This review focuses on the relevance of autophagy in fibrosis, with a special emphasis on IBD-related fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yun Zhou, Yun Jie Sheng, Cheng Yan Li, Li Zou, Chao Ying Tong, Yang Zhang, Gang Cao, Dan Shou
Summary: Bone metabolism is crucial for maintaining bone health. Natural polysaccharides have beneficial effects on bone metabolism. Polysaccharides can regulate bone metabolism by influencing the intestinal flora. Polysaccharides from traditional Chinese medicines and dietary fibers can enrich the intestinal microbiota and enhance bone metabolism. The regulation of intestinal flora by polysaccharides may be related to short-chain fatty acids, immunity, and hormone regulation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Microbiology
Shruti Ahlawat, Pramod Kumar, Hari Mohan, Sandeep Goyal, Krishna Kant Sharma
Summary: The human gut microbiota plays a crucial role in host health, with alterations in composition leading to the development of gastrointestinal disorders. Modulating gut microbiota composition and utilizing advanced treatment methods are key approaches for managing gut disorders in the future.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Microbiology
Siyu Li, Kan Xu, Yi Cheng, Lu Chen, Ailin Yi, Zhifeng Xiao, Xuefei Zhao, Minjia Chen, Yuting Tian, Wei Meng, Zongyuan Tang, Shuhong Zhou, Guangcong Ruan, Yanling Wei
Summary: This article summarizes recent studies on enterobacterial interactions among the host, enterobacteria, and their metabolite products and discusses potential therapeutic options for inflammatory bowel disease (IBD). Intestinal flora interactions in IBD are affected by reduced bacterial diversity, impact the immune system, and are influenced by factors such as host genetics and diet. Enterobacterial metabolites play important roles in enterobacterial interactions, especially in the progression of IBD. Probiotics, prebiotics, and functional foods have shown potential therapeutic benefits in IBD through enterobacterial interactions.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rolf Reiter, Florian N. Loch, Carsten Kamphues, Christian Bayerl, Stephan R. Marticorena Garcia, Britta Siegmund, Anja A. Kuehl, Bernd Hamm, Juergen Braun, Ingolf Sack, Patrick Asbach
Summary: This study tested the feasibility of MR elastography of the gut in healthy volunteers and IBD patients, showing excellent diagnostic performance in predicting IBD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Food Science & Technology
Li Zhang, Xinzhou Wang, Xin Zhang
Summary: Intestinal flora plays a key role in maintaining human health and can be regulated through dietary polysaccharides to improve metabolic disorders. However, this area has not received enough attention.
Article
Food Science & Technology
Ningyang Li, Chaofan Wang, Milen I. Georgiev, Vivek K. Bajpai, Rosa Tundis, Jesus Simal-Gandara, Xiaoming Lu, Jianbo Xiao, Xiaozhen Tang, Xuguang Qiao
Summary: Polysaccharides as anticancer agents have great potential for application, but their complex structure and unclear mechanism of action have hindered their research and clinical application.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Engineering, Environmental
Han Liu, Jinru Sun, Mingkai Wang, Sicheng Wang, Jiacan Su, Can Xu
Summary: Inflammatory bowel disease (IBD) is a serious gastrointestinal disease characterized by pain, diarrhea, and bloody stools. Intestinal organoids and organoids extracellular vesicles (OEVs) have shown great potential in IBD treatment. Intestinal organoids have various applications in disease modeling, drug development, and host-microbe interactions, while OEVs have physiological effects and can participate in physiological and pathological processes. This review provides an overview of IBD and its current treatments, as well as the construction and applications of intestinal organoids and OEVs in IBD treatment. The advantages and challenges of these approaches are also discussed.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Alvaro Rol, Toni Todorovski, Pau Martin-Malpartida, Anna Escola, Elena Gonzalez-Rey, Eric Aragon, Xavier Verdaguer, Mariona Valles-Miret, Josep Farrera-Sinfreu, Eduard Puig, Jimena Fernandez-Carneado, Berta Ponsati, Mario Delgado, Antoni Riera, Maria J. Macias
Summary: Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are characterized by chronic inflammation of the gastrointestinal tract and disrupted immune responses. Researchers have examined Cortistatin analogues that have enhanced half-life stability while maintaining immunomodulatory functionality.
NATURE COMMUNICATIONS
(2021)
Review
Plant Sciences
Baoyu Ji, Liangshuang Xuan, Yunxiang Zhang, Wenrong Mu, Kee-Yoeup Paek, So-Young Park, Juan Wang, Wenyuan Gao
Summary: Plant tissue culture technology is widely used for various purposes, such as natural compound production, functional gene research, plant micropropagation, plant breeding, and crop improvement. The accumulation of secondary metabolites in plant tissues is influenced by growth conditions, endogenous substances, and various multi-domain technologies, including artificial intelligence, biosensors, bioreactors, multi-omics monitoring, and nanomaterials, have greatly contributed to the field.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
