Article
Biochemistry & Molecular Biology
Yang Shi, Yun-Fang Ye, Bi-Wei Zhang, Yong Liu, Jun-Hui Wang
Summary: UP1-1, an active component isolated from Chinese Huangshan Umbilicaria esculenta, showed good immunostimulatory activity by promoting phagocytic activity and NO production of RAW 264.7 cells, as well as significantly improving cell proliferation at a concentration of 50 μg/mL.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nutrition & Dietetics
Bi Luo, Jia Lv, Kejie Li, Peiran Liao, Peng Chen
Summary: This study successfully extracted a new polysaccharide K-CMLP from Citrus medica L. var. sarcodactylis and analyzed its structure and bioactivities. The results showed that K-CMLP exhibited strong free-radical-scavenging properties and inhibited the production of pro-inflammatory cytokines and reactive oxygen species.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Guijie Chen, Yixun Bai, Ziqi Zeng, Yujia Peng, Wangting Zhou, Wenbiao Shen, Xiaoxiong Zeng, Zhonghua Liu
Summary: The polysaccharide fraction FBTPS-2-1 extracted from Fuzhuan brick tea showed potential immunostimulatory activity, enhancing phagocytosis of macrophages and promoting the secretion of inflammatory cytokines. This indicates that FBTPS-2-1 could be a functional food for improving human health by modulating the host immune reaction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Min Yu, Yuandan Xia, Wangling Xie, Yunlong Li, Xinjun Yu, Jianyong Zheng, Yinjun Zhang
Summary: In this study, pectinase-based and ultrasonic-assisted extraction method was used to extract pectic oligosaccharides (POS) from finger citron pomace, achieving a maximum conversion rate of 64.5%. The purified FCPOS-1, a homogeneous oligosaccharide with remarkable antioxidant properties, showed potential as a natural antioxidant for applications in the food and pharmaceutical industries.
Article
Nutrition & Dietetics
Guifeng Zhang, Chuang Liu, Rentang Zhang
Summary: This study extracted a novel acidic polysaccharide BJP-2 from blackened jujube and analyzed its chemical characteristics. The results showed that BJP-2 could inhibit cancer cell proliferation by inducing apoptosis and block cancer cell invasion and metastasis. Further protein analysis revealed that BJP-2 exhibited anti-tumor activity through the mitochondria-dependent pathway.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Jiahui Wang, Jing Nie, De Wang, Hui Liu, Meng Liu, Yanjing Yang, Shian Zhong
Summary: Coriolus versicolor (in Chinese), also known as Yun Zhi, is a traditional Chinese medicine widely used as a functional food. In this study, a homogeneous polysaccharide, YZP-la, was isolated from C. versicolor and its structure was determined. YZP-la showed significant anticancer activity by inhibiting cell migration and inducing cell apoptosis.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Food Science & Technology
Vikas Dadwal, Robin Joshi, Mahesh Gupta
Summary: This study focused on metabolomic analysis of different parts of Citrus fruit using targeted and untargeted approaches. Different compounds were found in different parts of the fruit, with the highest concentration in the exocarp. The biological activities and potential therapeutic applications of these metabolites were investigated using computational and in vitro assays, showing promising results.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jung Sik Lim, Sarang Cho, Peter Capek, Seong Cheol Kim, Roman Bleha, Doo Jin Choi, Jin Ree, Jisun Lee, Andriy Synytsya, Yong Il Park
Summary: In this study, a polysaccharide fraction PNE-P1 was isolated from pine nuts and found to promote macrophage proliferation, induce the secretion of proinflammatory cytokines and chemokines, enhance the expression of related enzymes and nitric oxide, and induce macrophage-mediated phagocytosis of apoptotic cells.
CARBOHYDRATE RESEARCH
(2023)
Article
Chemistry, Applied
Chen Shen, Teng Wang, Feng Guo, Kunlai Sun, Bin Wang, Jie Wang, Zefeng Zhang, Xing Zhang, Yuqin Zhao, Yin Chen
Summary: A novel heteropolysaccharide fraction (SP0.1-1) was isolated from Sea buckthorn berries, with a specific composition and structure. Supplementing with SP0.1-1 extended fruit flies' lifespan, enhanced antioxidant enzyme activities, and reduced oxidative damage, showing potential for sea buckthorn polysaccharide products development.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Wei Liu, Zehua Li, Kai Yang, Peilong Sun, Ming Cai
Summary: Finger citron essential oil (FCEO) encapsulated by nanoemulsion can improve its digestion in the colon and its effects on human gut microbiota, promoting the growth of beneficial bacteria and suppressing the growth of harmful bacteria. Therefore, FCEO may have potential applications in food preservation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Polymer Science
Jing Liu, Xuemeng Zhang, Jingsong Zhang, Mengqiu Yan, Deshun Li, Shuai Zhou, Jie Feng, Yanfang Liu
Summary: In this study, cell wall polysaccharides were extracted from Sparassis latifolia fruit bodies using different extraction methods. The polysaccharide fractions were then characterized and their in vitro immunity activities were studied. The results showed that the superfine-grinding assisted extraction method had the highest yield of polysaccharides, and the KOH extraction method was efficient in preparing bioactive beta-(1 -> 3, 1 -> 6)-glucan as a food ingredient.
Article
Chemistry, Analytical
Fateme Kalhori, Helya Yazdyani, Fatemeh Khademorezaeian, Negar Hamzkanloo, Parisa Mokaberi, Sare Hosseini, Jamshidkhan Chamani
Summary: In this study, cellulose nanocrystals (CNCs) were successfully extracted from Citrus medica L. pericarp using alkaline pretreatment and two-step bleaching. The extracted CNCs showed good morphological properties, no cytotoxic effects, and interaction with HMG-CoA reductase.
Article
Chemistry, Applied
Hui Zhang, Chenchen Li, Phoency F. H. Lai, Jinshi Chen, Fan Xie, Yongjun Xia, Lianzhong Ai
Summary: Water-extracted polysaccharides from Russula vinosa Lindblad (WRP) were found to possess potential immunostimulatory activity, promoting macrophage proliferation, phagocytosis, and the release of nitric oxide and cytokines. Among the fractions, WRP-1 exhibited the best immunostimulatory effects with a unique structure and conformation.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Rong-An Cao, RuiXue Ji, Mehdi Tabarsa, JianQiang Zhang, LingQi Meng, ChengTai Zhang, JiaMiao Zhang, LiDong Wang, Rui Wu, ChangYuan Wang, ChengHao Jin, SangGuan You
Summary: The polysaccharide extracted from A. asphodeloides rhizomes consists of neutral sugars, uronic acids, and sulfate esters, showing stimulating effects on cell production and significant inhibitory effects on cancer cell lines, indicating potential medicinal and functional food applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Linan Zhou, Ziteng Song, Shaojie Zhang, Yeling Li, Jing Xu, Yuanqiang Guo
Summary: The study synthesized stable and well-dispersed selenium nanoparticles, CL90-Tw-SeNP2, which demonstrated significant anti-tumor effects against HepG2 cells. By inducing cell apoptosis, CL90-Tw-SeNP2 showed potential for inhibiting the proliferation of liver cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)