Article
Biochemistry & Molecular Biology
Meltem Kolgazi, Sumeyye Cilingir, Ozgur Yilmaz, Merve Gemici, Hasan Yazar, Samed Ozer, Merve Acikel-Elmas, Serap Arbak, Guldal Gulec Suyen
Summary: The study found that caffeic acid can ameliorate ethanol-induced gastric mucosal damage, with the nitric oxide pathway contributing to this effect but a lack of evidence for the muscarinic cholinergic system's contribution.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Nutrition & Dietetics
Yutong Yuan, Xinyi Wang, Yumeng Wang, Yaqi Liu, Liang Zhao, Lei Zhao, Shengbao Cai
Summary: This study found that walnut peptides have protective and restorative effects on ethanol-induced gastric mucosal injury in mice, possibly by inhibiting inflammation and oxidative stress and improving cellular antioxidant activity.
Article
Polymer Science
Yuanyuan Wei, Jianzhu Ju, Costantino Creton, Tetsuharu Narita
Summary: The researchers discovered the phenomenon of strain-induced crystallization (SIC) in highly swollen and associative hydrogels by introducing extremely large deformation through indentation with a needle. They found that SIC occurs close to the needle tip upon large strain, displacing the nucleation of a crack from the tip to a position further away. The morphology of the fracture and the force needed to induce gel fracture can be controlled by manipulating temperature and cross-linking.
Article
Chemistry, Physical
Sanghamitra Debta, Sonam Zangpo Bhutia, Dillip K. Satapathy, Pijush Ghosh
Summary: In this study, we report an unusual thermomechanical response in a hydrogel, where the elastic modulus increases in a certain temperature range and then sharply decreases with a further increase in temperature. We establish that the desorption of different types of water with distinct binding energy affects the consolidation and relaxation behavior of the matrix, which in turn influences the mechanical properties at different temperatures.
Review
Pharmacology & Pharmacy
Xueyan Jia, Yihuai He, Lin Li, Delin Xu
Summary: This paper provides an overview of the therapeutic effects and pharmacological mechanisms of traditional Chinese medications on gastric mucosal injury, highlighting their remarkable capacity to restore gastric mucosa after damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Chunhui Luo, Min Huang, Xinxin Sun, Ning Wei, Huan Shi, Hui Li, Min Lin, Jing Sun
Summary: Fabricating artificial materials that mimic the structures and properties of tendons is of great significance. Researchers have developed a poly(vinyl alcohol) hydrogel with hierarchically anisotropic structures, exhibiting excellent mechanical properties, swelling resistance, and cytocompatibility. This hydrogel holds potential for various biotechnological and biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Dahee Yeo, Su-Jung Hwang, Ye-Seul Song, Hyo-Jong Lee
Summary: Alpha-humulene has been found to have a protective role against gastric injury in vivo and in vitro by inhibiting histamine release, reducing oxidative stress, increasing antioxidant levels, and stimulating mucosal protective factors. This compound shows potential as a drug candidate for the treatment of stress-induced or alcoholic gastritis.
Article
Plant Sciences
Guan-Yu Wang, Sheng-Yi Chen, Ying-Yin Chen, Cheng-Jie Hong, Yi-Hao Hsu, Gow-Chin Yen
Summary: The results of this study demonstrated the remarkable gastroprotective effect of 80EETC treatment in vitro and in vivo, including suppressing inflammatory mediator protein levels, improving antiapoptotic ability and wound healing capability, promoting gastric mucosal healing, increasing gut microbiota diversity, and short-chain fatty acid production. These findings are the first to show the powerful protective effect of T. khasianum Clarke leaves against gastric mucosal injury development.
Article
Chemistry, Applied
Monika Muchova, Lukas Munster, Alzbeta Vavrova, Zdenka Capakova, Ivo Kuritka, Jan Vicha
Summary: Little is known about the link between the macromolecular architecture of dialdehyde polysaccharides (DAPs), their crosslinking capabilities, and the properties of resulting hydrogels. In this study, DAPs based on cellulose, dextrin, dextran, and hyaluronate were compared as crosslinkers for poly(vinyl alcohol), PVA. The study investigated the effects of crosslinker structure, molecular weight, aldehyde group density per macromolecule, and the size of spontaneously formed crosslinker nano-assemblies on the swelling, network parameters, viscoelastic properties, porosity, and cytotoxicity of PVA/DAP hydrogels. The findings reveal that crosslinkers based on linear polysaccharides perform more reliably, while the presence of branching can have both beneficial and detrimental effects at lower crosslinker concentrations.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Peipei Yu, Guangzhu Zhou, Rongchao Yang, Yinming Li, Lingyan Zhang, Luguang Sun, Xiaoning Fu, Tong Hao
Summary: An ion imprinted composite hydrogel was prepared in an environmentally friendly way for treating Ni(II)-containing wastewater. The composite material showed good selective performance for Ni(II) separation, with selective coefficients of 1.646 for Ni(II)/Mg(II), 2.453 for Ni(II)/Zn(II), and 1.973 for Ni(II)/Cu(II). The adsorption kinetics followed pseudo-second-order kinetics and Langmuir model, and XPS analysis showed Ni(II) complexed with hydroxyl groups. Overall, the ion imprinted composite hydrogel is a green and selective adsorbent for Ni(II) removal from wastewater.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Materials Science, Multidisciplinary
Xu Zhang, Ye He, Xuan Li, Chuanchuan Lin, Zhang Yuan, Liangliang Dai, Feng Ma, Yi Lv, Tony Jun Huang, Mudan Ren, Kaiyong Cai, Shuixiang He
Summary: This study reports a hybrid hydrogel for the treatment of gastric ulcers induced by endoscopic submucosal dissection (ESD). The hydrogel, loaded with drug-carrying nanoparticles, showed unique stability in gastric tissue and released the drug slowly, inducing polarization of macrophages and promoting gastric ulcer healing in an in vivo model.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Chuang Dong, Jiahua Zhou, Dongjian Shi, Yufang Song, Xi Yu, Weifu Dong, Mingqing Chen, Daisaku Kaneko
Summary: A one-step mild method for preparing PVA hydrogels, inducing PVA crystallization through small molecules containing hydroxyl and carboxyl groups, has been developed to overcome shortcomings of the traditional freeze-thaw method. The obtained hydrogels exhibit high mechanical properties, atypical plasticity, short gelation time, and repeatable sol-gel transformation.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hui-Yu Ye, Zhen-Zi Shang, Feng-Yun Zhang, Xue-Qiang Zha, Qiang-Ming Li, Jian-Ping Luo
Summary: This study aimed to explore the potential mechanism of Dendrobium huoshanense stem polysaccharide (cDHPS) in ameliorating alcohol-induced gastric ulcer (GU) by strengthening the gastric mucosal barrier and reducing inflammation. The results showed that cDHPS effectively increased mucus secretion and tight junction protein expression in normal rats, while it alleviated alcohol-induced gastric mucosal injury and inflammation in GU rats by strengthening the gastric mucosal barrier. Furthermore, cDHPS activated Nrf2 signaling and promoted antioxidant enzymes activities in both normal and GU rats. These findings suggest that cDHPS pretreatment can protect the gastric mucosa from oxidative stress and inflammation by strengthening the gastric mucosal barrier through the activation of Nrf2 signaling.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Huifan Liu, Shanshan Zhuang, Churong Liang, Junjun He, Charles Stephen Brennan, Margert Anne Brennan, Lukai Ma, Gengsheng Xiao, Hao Chen, Shuo Wan
Summary: AVLP-2 is a novel acidic polysaccharide isolated from Amomum villosum Lour. It has antioxidant and anti-inflammatory effects by regulating ROS and inflammatory factors. Animal experiments demonstrate that AVLP-2 can improve the oxidative stress status of the gastric mucosa and reduce alcohol-induced inflammation.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Minjie Pei, Xiaotong Peng, Tingting Wan, Penghui Fan, Hongjun Yang, Xin Liu, Weilin Xu, Yingshan Zhou, Pu Xiao
Summary: The research synthesized PVA hydrogels with excellent performance, and significantly improved their tensile and compression strength through double-crosslinking. The hydrogel with the optimum composition can withstand a weight about 2220 times of its own weight, and exhibits good cytocompatibility.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)