期刊
CARBOHYDRATE POLYMERS
卷 272, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118494
关键词
3D scaffolds; Plant derived cellulose; Decellularization; Chitosan; Biocompatibility
资金
- Science and Engineering Research Board (SERB) of the Department of Science and Technology (DST), New Delhi [SRG/2019/001157]
This study utilized decellularized Borassus flabellifer immature endosperm to produce cellulose scaffolds, which were further treated with chitosan to create cellulose-chitosan hybrid scaffolds. Both scaffolds showed adequate swelling, controlled porosity, and enhanced physiochemical properties, with favorable adhesion and proliferation of fibroblasts. Plant-derived cellulosic scaffolds have potential as an alternative scaffolding material in regenerative medicine.
In this study, Borassus flabellifer (Linn.) (BF) immature endosperm was decellularized to produce three dimensional (3D) cellulose scaffolds that can support mammalian 3D cell culture. To this regard, we first evaluated the chemical composition, nutritive profile and pharmacological activities of BF endosperm. The results demonstrated that the BF tissue represented a complex concoction of polysaccharides with intrinsic phyto-ingredients which provide excellent pharmacological properties. Furthermore cellulosic scaffolds (CS) obtained from BF was treated with chitosan to produce cellulose-chitosan (CS/CHI) hybrid scaffolds. The comparative investigation on both scaffolds exhibited adequate swelling with controlled porosity and pore-size distribution. The physiochemical characterization showed reduced biodegradation, improved thermal stability and enhanced compressive strength in CS/CHI group. Biological studies reported favorable adhesion and proliferation of fibroblasts with evident cellular penetration and colonization on the both scaffolds. Taken together, plant derived cellulosic scaffolds could be used as an alternative scaffolding material in regenerative medicine.
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