Article
Pharmacology & Pharmacy
Dingding Wang, Weibo Wang, Ping Wang, Chuang Wang, Juntao Niu, Yang Liu, Yuzhou Chen
Summary: This paper summarizes the physiological factors of colonic drug delivery, the pathological characteristics of common colonic diseases, and the latest advances in the design, preparation, and characterization of natural polysaccharide hydrogels. It is expected to provide new references for colon-targeted oral hydrogel systems using natural polysaccharides as raw materials.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Niranjan G. Kotla, Rajbir Singh, Becca Baby, Swetha Rasala, Jawad Rasool, Sean O. Hynes, Darrell Martin, Laurence J. Egan, Praveen K. Vemula, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
Summary: Delivering drugs directly to inflamed intestinal sites to treat inflammatory bowel disease (IBD) is a challenge, but the development of targeted carrier systems such as IT-NCs shows promising therapeutic potential in improving treatment efficacy.
Review
Pharmacology & Pharmacy
Prashant Kesharwani, Rahul Chadar, Afsana Sheikh, Waleed Y. Rizg, Awaji Y. Safhi
Summary: Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in various solid tumors. It plays a significant role in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and immune responses. Nanocarriers have been developed to target the CD44 receptor and improve the efficacy of chemotherapy. Hyaluronic acid (HA) also plays a crucial role in cancer therapy and interacts with CD44, providing a potential approach for targeted therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Liucan Wang, Min Yu, Hua Yang
Summary: Effective colon drug delivery using nanocarrier-based nanomedicine is an international frontier research in IBD therapy, offering new opportunities for treatment and diagnoses. Functional nanocarriers with varying characteristics can improve target therapy and bioavailability, enhancing therapeutic efficacy in the treatment of IBD.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chenlan Xu, Shuting Chen, Cuiping Chen, Yangcan Ming, Jiahao Du, Jinyi Mu, Fang Luo, Da Huang, Na Wang, Zhenyu Lin, Zuquan Weng
Summary: Stimuli-responsive oral nanoparticles that co-deliver anti-inflammatory drugs and reactive oxygen species scavengers are a potentially effective therapy for inflammatory bowel disease (IBD). In this study, dexamethasone-loaded HES-CUR nanoparticles were developed as a colon-targeted oral formulation for treating IBD. These nanoparticles exhibited desirable characteristics and showed enhanced therapeutic efficacy in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Virali Arora, Mohammed A. S. Abourehab, Gyan Modi, Prashant Kesharwani
Summary: Dendrimers are synthetic nano-molecules with a spherical structure and a stardust topology. They are effective in solving the solubility problem in drug delivery and have been successfully used in chemotherapeutic drug delivery. Research has shown that dendrimers have potential in treating lung cancer and outperform other nanoparticles in terms of bioavailability and stability.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Vipul Yadav, Aileen House, Silvia Matiz, Laura E. McCoubrey, Kimberly A. Bettano, Leena Bhave, Meiyao Wang, Peter Fan, Siqun Zhou, Janice D. Woodhouse, Eirini Poimenidou, Liu Dou, Abdul W. Basit, Lily Y. Moy, Robert Saklatvala, Laxminarayan G. Hegde, Hongshi Yu
Summary: In this study, the feasibility of ileocolonic-targeted delivery of a pan-JAK inhibitor, tofacitinib, was explored and it was found that ileocolonic-targeted capsules significantly decreased systemic drug exposure and increased colonic tissue exposure compared to gastric release capsules and an oral solution. In a rat model of colonic inflammation, targeted tofacitinib capsules also significantly reduced concentrations of proinflammatory interleukin 6 in colonic tissue.
Review
Chemistry, Multidisciplinary
Rajeev Taliyan, Violina Kakoty, K. C. Sarathlal, Sanskruti Santosh Kharavtekar, Chandrashekar R. Karennanavar, Yogendra Kumar Choudhary, Gautam Singhvi, Yassine Riadi, Sunil Kumar Dubey, Prashant Kesharwani
Summary: Dementia is a progressive memory-related neurodegenerative disease observed in the geriatric population. The current therapeutics for Alzheimer's disease primarily target symptomatic management and face challenges in crossing the blood-brain barrier and blood-cerebrospinal fluid barrier. Nanocarriers show promise in facilitating targeted drug delivery for the management of Alzheimer's disease.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Peng Liu, Caifang Gao, Hongguo Chen, Chi Teng Vong, Xu Wu, Xudong Tang, Shengpeng Wang, Yitao Wang
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful symptoms and high risks of cancerization. There is no curative therapy for IBD at present, so the development of targeted drug delivery systems for the inflamed areas is highly advocated.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Jongyoon Shinn, Juyeon Lee, Seon Ah Lee, Seon Ju Lee, Ah Hyun Choi, Jung Seo Kim, Su Jin Kim, Hyo Jin Kim, Cherin Lee, Yejin Kim, Joohyeon Kim, Jonghee Choi, Byungchae Jung, Taeho Kim, HyeonTaek Nam, Hyungjun Kim, Yonghyun Lee
Summary: This review discusses the potential of RNA interference (RNAi) therapy for treating inflammatory bowel diseases (IBD) and the barriers in the gastrointestinal tract. It also presents the progress and challenges of oral siRNA delivery strategies.
Article
Engineering, Biomedical
Chong Zhang, Fen Zeng, Zhengyang Fan, Zhen He, Liang Tai, Qiang Peng, Yixin Zhang, Zhenhua Chao, Wenning Jiang, Lingyun Jia, Lulu Han
Summary: Inflammatory bowel disease (IBD) is a global public health challenge. Current medical treatments are not fully effective and may cause side effects. Researchers have developed a nanoparticle-based treatment strategy for IBD, which can target inflamed colon tissues and reduce systemic exposure of the drug. The nanoparticles also possess reactive oxygen species (ROS)-scavenging ability, which can alleviate inflammation and improve IBD symptoms.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Multidisciplinary
Andreea Nedelcu, Ofelia Mosteanu, Teodora Pop, Teodora Mocan, Lucian Mocan
Summary: Since the beginning of the 21st century, there have been continuous advances in nanoscience in areas such as computational nanomedicine, nanomaterial-based sensors, and biomedical engineering applications. A significant increase in incidence rates of inflammatory bowel disease (IBD) has been observed, including diseases like Crohn's disease (CD) and ulcerative colitis (UC). Nanoparticle-based approaches show promise in targeting therapy for IBD patients, regulating immune responses and acting as anti-inflammatory agents.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Dinakar Swastha, Nambolan Varsha, Suresh Aravind, Kavassery Balasubramanian Samyuktha, Muruganandam Mohaneswari Yokesh, Akshad Balde, Bakthavatchalam Loganathan Ayilya, Soottawat Benjakul, Se -Kwon Kim, Rasool Abdul Nazeer
Summary: Inflammatory bowel disease (IBD) is a common inflammatory disorder affecting the gastrointestinal tract. Alginate (AG), as a marine-derived polysaccharide, has been extensively studied for its properties in drug delivery systems for IBD treatment. AG-based carrier systems, including nanotechnology-based systems and hydrogels, have shown potential in targeted drug delivery and tissue regeneration. This review focuses on the pathogenesis of IBD, currently studied medications, AG-based drug delivery systems, and their properties for alleviating IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Chi-Pin James Wang, Min Ji Byun, Se-Na Kim, Wooram Park, Hee Ho Park, Tae-Hyung Kim, Jung Seung Lee, Chun Gwon Park
Summary: Inflammatory bowel diseases (IBDs) are gastrointestinal inflammatory disorders featuring chronic intestinal inflammation. Novel biomaterial-based platforms have been developed to deliver drugs to damaged sites with increased efficacy and reduced side effects in IBD treatments.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Environmental
Xin Li, Sha Fang, Yang Yu, Hongyu Yang, Yuefeng Rao, Dongsheng Hong, Chao Lu, Mengli Yu, Xiaoyang Lu, Chaohui Yu, Qingwei Zhao
Summary: In this study, an inflammatory microenvironment-responsive nanocomplex was developed for oral administration of Infliximab for inflammatory bowel disease (IBD) treatment. The nanocomplex showed high drug loading, inflammation targeting, and bioresponsive controlled release, and exhibited great efficacy in reducing intestinal inflammation and systemic exposure.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)