Article
Chemistry, Applied
Rixiang Su, Peiyuan Li, Ying Zhang, Yingbin Lv, Fangzhou Wen, Wei Su
Summary: Researchers have successfully developed an in situ-formed antibacterial wound dressing with temperature stimulation and near-infrared radiation (NIR) responsive ability. The dressing, called PTCPP, possesses injectability, photothermal stability, sustained release properties, and cytocompatibility. In vitro and in vivo experiments demonstrated its high antibacterial efficacy against Staphylococcus aureus and Escherichia coli, as well as its ability to adapt to wound shape and promote wound healing in bacterial infections.
CARBOHYDRATE POLYMERS
(2023)
Article
Nanoscience & Nanotechnology
Xin Zhang, Lishan Chen, Chao Zhang, Liqiong Liao
Summary: The study introduces a novel NIR-responsive hydrogel actuator incorporating Fe3+/TA, demonstrating enhanced mechanical properties and photothermal effect. Under NIR irradiation, Fe3+/TA within the hydrogel converts light energy into heat, causing the hydrogel to bend upward in the heated region with excellent repeatability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Min A. Gwak, Bo Min Hong, Ji Min Seok, Su A. Park, Won Ho Park
Summary: In this study, an HA-catechol conjugate (HA-Cat) was synthesized by reacting the HA polymer with dopamine to improve its adhesion to various substrates. The addition of tannic acid (TA) improved both the adhesive and compressive properties of the HA-Cat hydrogels, showing great potential as cost-effective and biocompatible medical adhesives.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Paper & Wood
Celile Demirbilek Bucak
Summary: In this study, a new method for preparing hydrogel beads from Na-Alg/TA using citric acid as a crosslinking agent was developed. The properties of the hydrogel beads and the release of phenolic compound were investigated. This work is important for curative medicine and tissue engineering.
Article
Polymer Science
Ji-Bong Choi, Yu-Kyoung Kim, Seon-Mi Byeon, Jung-Eun Park, Tae-Sung Bae, Yong-Seok Jang, Min-Ho Lee
Summary: A hydrogel was prepared using single and double crosslinking methods with GelMA, and the double crosslinked hydrogel showed improved mechanical strength and better cell compatibility compared to the single crosslinked group. In animal testing, the double crosslinked hydrogel exhibited a stronger osteoinductive response, highlighting its potential for bone regeneration applications.
Article
Engineering, Environmental
Xiaodong He, Gnanasekar Sathishkumar, Kasi Gopinath, Kai Zhang, Zhisong Lu, Changming Li, En-Tang Kang, Liqun Xu
Summary: This study developed a novel biomaterial for medical devices with excellent antibacterial and antifouling properties, providing an effective strategy to combat medical device-associated infections.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Medicine, Research & Experimental
Motaleb Ghasemian, Fahimeh Kazeminava, Ashkan Naseri, Soheila Mohebzadeh, Mahmoud Abbaszadeh, Hossein Samadi Kafil, Zainab Ahmadian
Summary: Significant advancements have been made in cancer therapy, but challenges such as multidrug resistance, drug instability, and side effects still exist. Natural compounds, especially polyphenols, have shown great potential in overcoming these challenges due to their superb biological activities. Tannic acid (TA), as one of the most famous polyphenols, has attracted attention in the field of cancer treatment with its unique structural and biological features.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Long Hua, Hu Qian, Ting Lei, Wenbin Liu, Xi He, Yihe Hu, Pengfei Lei
Summary: This study successfully prepared a composite photothermal hydrogel with photothermal effect and controllable drug release ability, which improved self-cleaning ability, promoted cell growth, enhanced antibacterial properties, and showed good biocompatibility. The experiments demonstrated that the hydrogel could effectively promote the repair of infectious skin defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Min Xu, Shaozhen Wu, Li Ding, Caijiao Lu, Huangjing Qian, Jinmiao Qu, Yu Chen
Summary: This study innovatively prepared adhesive piezoelectric antibacterial hydrogels with carboxymethyl chitosan (CMCS), tannic acid (TA), carbomer (CBM), and piezoelectric FeWO4 nanorods. The hydrogels exhibited high expansibility, degradability, and adjustable rheological properties. The piezoelectric effect of FeWO4 was triggered by ultrasound, effectively generating reactive oxygen species and preventing wound infection, thus promoting skin wound healing in bacteria-infected mice.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Applied
Junyi Du, Xixia Wang, Ruiyi Song, Hui Lv, Shiyu Zong, Qian Zhao, Jingyu Wu, Xiaolu Wen, Jianxin Jiang, Jiufang Duan
Summary: This study investigates the reversible adhesion of galactomannan hydrogels and develops a double network structure that exhibits conductivity for flexible sensors. The results provide a new approach for the design and development of advanced skin sensors.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Minmin Chang, Xinxin Liu, Qixuan Lin, Weiying Li, Xiaohui Wang, Junli Ren
Summary: An underwater adhesive hydrogel has been fabricated by introducing electrostatic interactions inspired by mussel. The hydrogel shows excellent mechanical properties, UV-blocking performance, and good adhesion in air and underwater, making it suitable for human motion and health monitoring.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Fengcai Lin, Wenyan Lin, Jingwen Chen, Chenyi Sun, Xiaoxiao Zheng, Yanlian Xu, Beili Lu, Jipeng Chen, Biao Huang
Summary: In this study, a stable cellulose hydrogel was successfully constructed through the self-assembly of cellulose nanocrystals induced by tannic acid. The hydrogels exhibited a porous network structure with tunable mechanical properties and rapid self-healing ability. The structural stability of the hydrogel could be further enhanced and adjusted by introducing coordination bonding with metal cations.
Article
Materials Science, Paper & Wood
Mingzhu Zhang, Meng Li, Ningya Yu, Shengpei Su, Xiaomin Zhang
Summary: A series of tannic acid-modified cellulose hydrogels embedded with size-controlled AgCl nanoparticles were successfully fabricated, showing excellent catalytic activity in the reduction of 4-nitrophenol. The size of AgCl nanoparticles could be adjusted by varying the tannic acid content, with the smallest nanoparticles exhibiting the highest catalytic activity. The strategy of catalysis along with reduction provided a novel path for catalytic systems involving noble metal catalysts.
Article
Materials Science, Multidisciplinary
Nolan Wen, Enze Qian, Yunqing Kang
Summary: This study aims to develop and characterize a new hydrogel system with tunable stretchability and adhesive properties. The hydrogel was prepared using a one-pot method, crosslinked with acrylamide, natural plant derived materials (pectin and tannic acid), ammonium persulfate, N, N'-methylenebisacrylamide, and iron chloride, with or without tetramethylethylenediamine. Incorporating laponite powders significantly improved the compressive strength and stability of the hydrogel but reduced its stretchability. The newly developed hydrogel formulations demonstrate tunable mechanical properties and good adhesion, showing great potentials in various biomedical applications.
Article
Chemistry, Applied
Hankun Cao, Du Xiang, Xin Zhou, Pengpeng Yue, Yongkang Zou, Zibiao Zhong, Yongsheng Ma, Lizhe Wang, Shuangquan Wu, Qifa Ye
Summary: Novel multifunctional chitin/PEGDE-tannic acid (CPT) hydrogels were successfully fabricated, showing stable three-dimensional porous structure, excellent biocompatibility, improved mechanical properties, and various functions including antibacterial, antioxidant, hemostatic activities. These CPT hydrogels could promote wound healing by regulating inflammatory responses, promoting collagen deposition, and blood vessel formation. This study provides a useful strategy to fabricate multifunctional CPT hydrogels and they hold promise for wound healing applications.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)