Article
Cell Biology
Beibei Ye, Yuansheng Duan, Mengqian Zhou, Yuxuan Wang, Qingchuan Lai, Kai Yue, Jiayan Cao, Yansheng Wu, Xudong Wang, Chao Jing
Summary: This study aimed to investigate the interaction and regulatory mechanism between miR-21, hypoxia, and CAFs in head and neck squamous cell carcinoma (HNSCC) metastasis. The results showed that HIF1a upregulated the transcription of miR-21, promoted exosome secretion, activated CAFs, and facilitated tumor invasion and lymph node metastasis. The findings suggest that hypoxic tumor cell-derived exosomal miR-21 might be a potential therapeutic target for preventing or delaying HNSCC invasion and metastasis.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Xueping Wang, Xiaoyuan Zhu, Yulin Zhao
Summary: The study reveals that exosomal miR-185-3p promotes tumor growth by mediating RAB25, which can be effectively targeted for HNSCC treatment. Targeting miR-185-3p/RAB25 significantly inhibits tumor growth and enhances drug response to chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qiang Huang, Yu-Jie Shen, Chi-Yao Hsueh, Yi-Fan Zhang, Xiao-Hui Yuan, Yu-Juan Zhou, Jiao-Yu Li, Lan Lin, Chun-Ping Wu, Chun-Yan Hu
Summary: This study aimed to investigate the potential of plasma extracellular vesicles (EVs) miR-99a-5p as a diagnostic biomarker for head and neck squamous cell carcinoma (HNSCC). The results showed that plasma EVs miR-99a-5p could be used to predict HNSCC.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Oncology
Yuehan Wan, Rosalie G. Hoyle, Nan Xie, Wenjin Wang, Hongshi Cai, Ming Zhang, Zhikun Ma, Gan Xiong, Xiuyun Xu, Zhengxian Huang, Xiqiang Liu, Jiong Li, Cheng Wang
Summary: MiR-21-5p, an oncogenic miRNA, is upregulated in many solid cancers through a super-enhancer associated with the MIR21 gene (MIR21-SE). The key transcription factor FOSL1 directly controls miR-21-5p expression by interacting with MIR21-SE in head and neck squamous cell carcinoma (HNSCC). Clinical studies confirmed a positive correlation between miR-21-5p expression and FOSL1 expression, suggesting a potential role of FOSL1-SE in driving miR-21-5p expression to promote malignant progression of HNSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Li, Shouwei Zhao, Yu Fu, Ping Zhang, Zhenxing Zhang, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: The study demonstrates that downregulation of miR-34a-5p is associated with the progression of HNSCC tumors and cells. Functionally, miR-34a-5p inhibits proliferation, migratory/invasive activity, and epithelial-mesenchymal transition in HNSCC cells. Mechanistically, miR-34a-5p suppresses FLOT-2 expression and activates the MEK/ERK1/2 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Wittaya Panvongsa, D. Michiel Pegtel, Jens Voortman
Summary: MicroRNAs (miRNAs) are small non-coding RNA molecules that play a key regulatory role in various biological processes. Dysregulation of miRNAs is associated with human diseases, particularly cancer. Extracellular vesicles (EVs) are important for intercellular communication, and miRNAs carried by EVs are involved in cell-to-cell interactions, including tumor development. In recent years, there has been rapid growth in understanding the molecular mechanisms and clinical importance of EV-miRNAs in head and neck squamous cell carcinoma (HNSCC). EV-miRNAs have multiple effects on HNSCC tumorigenesis, including tumor proliferation, invasion and metastasis, immune modulation, and treatment resistance. EV-miRNAs also have the potential to be used as biomarkers for screening, early diagnosis, and disease monitoring in liquid biopsies. Furthermore, EV-miRNAs hold promise as a novel therapeutic target.
Review
Biochemistry & Molecular Biology
Ajaz A. Bhat, Parvaiz Yousuf, Nissar A. Wani, Arshi Rizwan, Shyam S. Chauhan, Mushtaq A. Siddiqi, Davide Bedognetti, Wael El-Rifai, Michael P. Frenneaux, Surinder K. Batra, Mohammad Haris, Muzafar A. Macha
Summary: HNSCC is a highly aggressive disease with a poor prognosis, and understanding the complex TME interactions is crucial for new therapeutic interventions. The different molecular and immune landscapes between HPV+ve and HPV-ve tumors present new opportunities for individualized, targeted CIT regimens.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Tong Sha, Jia Li, Shiqun Sun, Jianing Li, Xuetao Zhao, Zehua Li, Zhi Cui
Summary: YEATS2 is highly expressed in HNSCC clinical samples, and its knockdown inhibits proliferation, induces apoptosis, and reduces migration and invasion capability in HNSCC cells. Additionally, miR-378a-5p is involved in the regulation of YEATS2 expression.
Article
Oncology
Juliette Mainguene, Sophie Vacher, Maud Kamal, Abderaouf Hamza, Julien Masliah-Planchon, Sylvain Baulande, Sabrina Ibadioune, Edith Borcoman, Wulfran Cacheux, Valentin Calugaru, Laura Courtois, Carole Crozes, Marc Deloger, Elodie Girard, Jean-Pierre Delord, Antoine Dubray-Vautrin, Linda Larbi Cherif, Celia Dupain, Emmanuelle Jeannot, Jerzy Klijanienko, Sonia Lameiras, Charlotte Lecerf, Anouchka Modesto, Alain Nicolas, Roman Rouzier, Esma Saada-Bouzid, Pierre Saintigny, Anne Sudaka, Nicolas Servant, Christophe Le Tourneau, Ivan Bieche
Summary: The study found that HPV integration is associated with overexpression of certain cancer genes (such as PDL1 and MYC) in HNSCC patients. This may indicate a role of HPV integration in the carcinogenesis of HNSCC.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Lihong He, Jiaxin Guo, Zhaona Fan, Shiwen Yang, Chi Zhang, Bin Cheng, Juan Xia
Summary: In this study, it was found that exosomes derived from cancer-associated fibroblasts (CAFs) contained more miR-146b-5p compared to exosomes derived from normal fibroblasts (NFs). miR-146b-5p promoted the malignant phenotype of oral squamous cell carcinoma (OSCC) by targeting HIPK3. Therefore, inhibiting exosomal miR-146b-5p secretion may be a promising therapeutic approach for OSCC.
CELLULAR SIGNALLING
(2023)
Article
Pathology
Gianluca Businello, Matteo Fassan, Silvia Degasperi, Giulia Traverso, Melania Scarpa, Imerio Angriman, Andromachi Kotsafti, Ignazio Castagliuolo, Marta Sbaraglia, Romeo Bardini, Marco Scarpa
Summary: The study suggests that HPV infection is not a factor associated with esophageal squamous cell carcinoma (ESCC) after head and neck squamous cell carcinoma (HNSCC). Instead, p53 overexpression is common in HNSCC-associated ESCCs. The altered immune microenvironment, characterized by dysregulated lymphomonocytic infiltration, may play a crucial role in the development of metachronous ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Masato Mima, Atsushi Okabe, Takayuki Hoshii, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Ryoji Fujiki, Bahityar Rahmutulla, Tomokazu Yoshizaki, Toyoyuki Hanazawa, Kiyoshi Misawa, Atsushi Kaneda
Summary: Human papillomavirus (HPV) plays a causal role in the development of head and neck squamous cell carcinoma (HNSCC) by integrating into the host genome and causing genomic alterations. This study analyzed the epigenome, transcriptome, and interactome of HPV-positive HNSCCs to understand the role of epigenetic dysregulation in tumorigenesis. The results showed that genes neighboring HPV integration sites were upregulated and correlated with oncogenic phenotypes in HPV-positive HNSCCs. The epigenetic activation of HPV-interacting regions (HPVIRs) contributed to the genesis of HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Ting Li, Juan Li, Haitao Wang, Jiayu Zhao, Mingze Yan, Hongjiang He, Shan Yu
Summary: This review highlights the potential of exosomes as biomarkers and therapeutic targets for head and neck squamous cell carcinoma (HNSCC), discussing their biological mechanisms and recent clinical application.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Chi Zhang, Hongfei Wang, Miao Deng, Lihong He, Fan Ping, Yuan He, Zhaona Fan, Bin Cheng, Juan Xia
Summary: miR-411-5p plays a crucial role in promoting metastasis in HNSCC by downregulating RYBP expression levels, indicating it as a potential novel target for HNSCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)