Zhang et al. conducted extensive single-cell immune compartment analyses of pre- and post-therapy triple-negative breast cancer and revealed potential mechanisms of T cell activation and patterns of immune evolution, which may inform future biomarkers of response and clinical benefit.
Immune checkpoint blockade plus chemotherapy is emerging as a standard treatment for some patients with triple-negative breast cancer (TNBC). In this issue of Cancer Cell, Zhang et al. employ extensive single-cell immune compartment analyses of preand post-therapy TNBC, and they reveal potential mechanisms of T cell activation and patterns of immune evolution that may inform future biomarkers of response and clinical benefit.
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