Article
Biology
Marie Loh, Weihua Zhang, Hong Kiat Ng, Katharina Schmid, Amel Lamri, Lin Tong, Meraj Ahmad, Jung-Jin Lee, Maggie C. Y. Ng, Lauren E. Petty, Cassandra N. Spracklen, Fumihiko Takeuchi, Md Tariqul Islam, Farzana Jasmine, Anuradhani Kasturiratne, Muhammad Kibriya, Karen L. Mohlke, Guillaume Pare, Gauri Prasad, Mohammad Shahriar, Miao Ling Chee, H. Janaka de Silva, James C. Engert, Hertzel C. Gerstein, K. Radha Mani, Charumathi Sabanayagam, Marijana Vujkovic, Ananda R. Wickremasinghe, Tien Yin Wong, Chittaranjan S. Yajnik, Salim Yusuf, Habibul Ahsan, Dwaipayan Bharadwaj, Sonia S. Anand, Jennifer E. Below, Michael Boehnke, Donald W. Bowden, Giriraj R. Chandak, Ching-Yu Cheng, Norihiro Kato, Anubha Mahajan, Xueling Sim, Mark McCarthy, Andrew P. Morris, Jaspal S. Kooner, Danish Saleheen, John C. Chambers
Summary: South Asians have a higher risk of developing type 2 diabetes (T2D). Through a genomewide association meta-analysis, researchers identified 21 novel genetic loci associated with T2D, which are linked to adiposity and glucose metabolism. A polygenic risk score based on South Asian-derived summary statistics can predict T2D risk.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Xiaohui Guo, Wenying Yang, Junqing Zhang, Xiaolin Dong, Ming Liu, Shenghong Gu, Felipe Lauand, Lingyu Li, Qiong Huang, Lei Kang, Elisabeth Souhami
Summary: This study found that iGlarLixi achieved greater improvements in glycemic control compared to iGlar and Lixi in the Asian Pacific population with type 2 diabetes, leading to a higher proportion of patients reaching target blood glucose levels.
DIABETES OBESITY & METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
Alejandra Marco, Marcos Pazos-Couselo, Jesus Moreno-Fernandez, Ana Diez-Fernandez, Manuela Alonso-Sampedro, Carmen Fernandez-Merino, Arturo Gonzalez-Quintela, Francisco Gude
Summary: This study investigated the prognostic value of time range metrics measured by continuous glucose monitoring for the development of type 2 diabetes. The results showed that time above range provides additional information to glycated hemoglobin in identifying individuals at higher risk of developing type 2 diabetes in a population-based study.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Biochemistry & Molecular Biology
Roy W. Beck
Summary: Automated insulin delivery systems, used in type 1 diabetes, hold promise for patients with type 2 diabetes and are expected to have a significant impact on public health.
Article
Multidisciplinary Sciences
Md Numan Islam, Md Golam Rabby, Md Munnaf Hossen, Md Mostafa Kamal, Md Ashrafuzzaman Zahid, Md Syduzzaman, Md Mahmudul Hasan
Summary: This study integrates risk genes and SNPs from genome-wide association studies and performs bioinformatics analyses, discovering four transcription factors associated with T2D and uncovering the potential roles of SNPs in chromatin interaction regulation and TF binding affinity. The GO study reveals enrichment in well-characterized signaling pathways and regulatory processes, while the KEGG pathway analysis identifies major T2D genes and potential therapeutic targets.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Endocrinology & Metabolism
Ronald M. Goldenberg, Vanita R. Aroda, Liana K. Billings, A. Sia Louise Christiansen, Anders Meller Donatsky, Ehsan Parvaresh Rizi, Gracjan Podgorski, Katarina Raslova, David C. Klonoff, Richard M. Bergenstal
Summary: This study compared the use of insulin degludec and glargine U100 in patients with type 2 diabetes, showing that degludec performed better in terms of TIR and time in tight glycaemic range.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
K. M. Venkat Narayan, Dimple Kondal, Sayuko Kobes, Lisa R. Staimez, Deepa Mohan, Unjali P. Gujral, Shivani A. Patel, Ranjit Mohan Anjana, Roopa Shivashankar, Mohammed K. Ali, Howard H. Chang, Masood Kadir, Dorairaj Prabhakaran, Natalie Daya, Elizabeth Selvin, Nikhil Tandon, Robert Hanson, Viswanathan Mohan
Summary: South Asians and Pima Indians have different diabetes incidence rates, with South Asians having a lower rate than Pima Indians at comparable BMI levels. However, among men with BMI <25, the risk of diabetes is five times higher in South Asians compared to Pima Indians.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Medicine, General & Internal
Klemen Dovc, Stefanie Lanzinger, Roque Cardona-Hernandez, Martin Tauschmann, Marco Marigliano, Valentino Cherubini, Romualdas Preiksa, Ulrike Schierloh, Helen Clapin, Fahed AlJaser, Julie Pelicand, Rishi Shukla, Torben Biester
Summary: The combined use of real-time continuous glucose monitoring (CGM) and an insulin pump in youths with type 1 diabetes is associated with a higher likelihood of achieving recommended clinical targets and time in range, as well as a lower likelihood of severe adverse events.
Article
Endocrinology & Metabolism
Ashleigh R. Homer, Frances C. Taylor, Paddy C. Dempsey, Michael J. Wheeler, Parneet Sethi, Melanie K. Townsend, Megan S. Grace, Daniel J. Green, Neale D. Cohen, Robyn N. Larsen, Bronwyn A. Kingwell, Neville Owen, David W. Dunstan
Summary: Interrupting prolonged sitting with 6-minute bouts of simple resistance activities every 60 minutes significantly reduced postprandial glucose and insulin responses in adults with medication-controlled type 2 diabetes. Other frequencies of interruptions and potential longer-term benefits require further examination for clinical relevance.
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: In this 26-week trial, researchers found that once-weekly treatment with dulaglutide has significant efficacy in improving glycemic control among youths with type 2 diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: The incidence of type 2 diabetes mellitus is increasing among youths. Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes, without an effect on BMI.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Bushra Mahmood, Lindsay Nettlefold, Maureen C. Ashe, Joseph H. Puyat, Tricia S. Tang
Summary: This study presents directly-measured physical activity and sedentary time in South Asian adults in Canada. The findings show high sedentary time and low moderate-to-vigorous physical activity (MVPA) in this population. Factors such as sex, BMI, season of assessment, and employment status were found to significantly impact MVPA levels.
Article
Multidisciplinary Sciences
Bushra Mahmood, Lindsay Nettlefold, Maureen C. Ashe, Joseph H. Puyat, Tricia S. Tang
Summary: South Asian adults in Canada have high sedentary time and low moderate-to-vigorous physical activity (MVPA). Efforts should focus on reducing sedentary time, increasing light physical activity (LPA), and promoting higher levels of MVPA.
Article
Endocrinology & Metabolism
Harpreet S. Bajaj, Melonie Burrows, Jessica Blavignac, Emilia Paron, Fernando Camacho, Errol Gould, Maxime Barakat
Summary: Sustained weight loss improves liver histology in non-alcoholic fatty liver disease. The study found that weight loss, especially in combination with medication treatment, can lead to improved liver health indicators such as ALT and FIB-4 levels.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Harpreet S. Bajaj, Richard M. Bergenstal, Andreas Christoffersen, Melanie J. Davies, Amoolya Gowda, Joakim Isendahl, Ildiko Lingvay, Peter A. Senior, Robert J. Silver, Roberto Trevisan, Julio Rosenstock
Summary: The study demonstrated that switching from daily basal insulin to once-weekly icodec was well tolerated and provided effective glycemic control. The use of a loading dose when switching to once-weekly icodec significantly increased the percent time in range during weeks 15 and 16 compared to once-daily IGlar U100, without increasing the risk of hypoglycemia.
Article
Endocrinology & Metabolism
Frederik Persson, Peter Rossing, Priya Vart, Glenn M. Chertow, Fan Fan Hou, Niels Jongs, John J. McMurray, Ricardo Correa-Rotter, Harpreet S. Bajaj, Bergur Stefansson, Robert D. Toto, Anna Maria Langkilde, David C. Wheeler, Hiddo J. L. Heerspink
Summary: The DAPA-CKD study demonstrated that dapagliflozin can reduce the risk of kidney and cardiovascular adverse outcomes in patients with chronic kidney disease, regardless of their baseline glycemic status. The effect of dapagliflozin on key outcomes remained consistent across different glycemic statuses, without significant adverse events reported.
Article
Endocrinology & Metabolism
Harpreet S. Bajaj, Hertzel C. Gerstein, Purnima Rao-Melacini, Jan Basile, Helen Colhoun, Ignacio Conget, William C. Cushman, Gilles R. Dagenais, Edward Franek, Markolf Hanefeld, Matyas Keltai, Mark Lakshmanan, Fernando Lanas, Lawrence A. Leiter, Patricio Lopez-Jaramillo, Valdis Pirags, Nana Pogosova, Jeffrey Probstfield, Peter Raubenheimer, Lars Ryden, Jonathan E. Shaw, Wayne H-H Sheu, Denis Xavier
Summary: The study showed that long-term use of dulaglutide may reduce the incidence of moderate or severe erectile dysfunction in men with type 2 diabetes. Men in the dulaglutide group had a lower incidence of erectile dysfunction and a lesser fall in erectile function subscore compared with the placebo group.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Letter
Endocrinology & Metabolism
Thomas R. Pieber, Harpreet S. Bajaj, Simon R. Heller, Ting Jia, Kamlesh Khunti, David C. Klonoff, Steen Ladelund, Lawrence A. Leiter, Lily Wagner, Athena Philis-Tsimikas
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Irene Hramiak, Hertzel C. Gerstein, Lawrence A. Leiter, Jean-Francois Yale, Harpreet S. Bajaj, John Stewart, Marie-Josee Toutounji, Stewart B. Harris
Summary: This study compared the efficacy and safety of a simple daily titration algorithm with a weekly dose adjustment of iGlarLixi in people with type 2 diabetes. The results showed that the daily titration algorithm was non-inferior and superior to the weekly titration in terms of glycemic control and weight.
DIABETES OBESITY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Athena Philis-Tsimikas, Harpreet S. Bajaj, Kamilla Begtrup, Roman Cailleteau, Amoolya Gowda, Ildiko Lingvay, Chantal Mathieu, David Russell-Jones, Julio Rosenstock
Summary: This article describes the clinical development program ONWARDS phase 3a, which investigates the use of once-weekly basal insulin icodec in the treatment of type 2 and type 1 diabetes. Six trials are being conducted to evaluate the efficacy and safety of icodec, with consideration of different clinical scenarios and comparator treatments.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ronnie Aronson, Ruth E. E. Brown, Lisa Chu, Harpreet S. S. Bajaj, Hasnain Khandwala, Alexander Abitbol, Nadia Malakieh, Ronald Goldenberg
Summary: The study aimed to investigate the effectiveness of intermittently scanned continuous glucose monitoring (isCGM) in managing type 2 diabetes with non-insulin therapies. The results showed that the use of isCGM device, in combination with diabetes self-management education, led to significant improvements in glycemic control and patient satisfaction compared to diabetes self-management education alone.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Chantal Mathieu, Bjorg Asbjornsdottir, Harpreet S. Bajaj, Wendy Lane, Ana Laura S. A. Matos, Sreenivasa Murthy, Karolina Stachlewska, Julio Rosenstock
Summary: The ONWARDS 4 trial aimed to compare the efficacy and safety of once-weekly insulin icodec with once-daily insulin glargine U100 in individuals with long-standing type 2 diabetes. The results showed that icodec demonstrated similar improvements in glycaemic control compared to glargine U100, with fewer basal insulin injections and no increase in hypoglycaemic rates. The trial had limitations including its relatively short duration and open-label design.
Article
Medicine, General & Internal
Harpreet S. Bajaj, Jens Aberle, Melanie Davies, Anders Meller Donatsky, Marie Frederiksen, Dilek G. Yavuz, Amoolya Gowda, Ildiko Lingvay, Bruce Bode
Summary: This study compared the effectiveness and safety of icodec titrated with a dosing guide app to once-daily basal insulin analogues in treating patients with type 2 diabetes. The results showed that icodec with app was more effective in reducing HbA1c levels, improving treatment satisfaction and compliance, with similar rates of hypoglycemia compared to OD analogues.
ANNALS OF INTERNAL MEDICINE
(2023)
Letter
Endocrinology & Metabolism
Dylan Mackay, Tahmina Rahman, Jonathan Little, Susie Jin, Harpreet S. Bajaj
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Hiren Patel, Kamlesh Khunti, Helena W. Rodbard, Harpreet S. Bajaj, Ross Bray, Zbigniew Kindracki, Angel Rodriguez
Summary: The impact of gastrointestinal adverse events, particularly nausea, vomiting, and diarrhea, on weight change was evaluated in participants with type 2 diabetes treated with tirzepatide. Results showed that these adverse events were common but had minimal contribution to weight reduction, indicating that tirzepatide is effective in weight loss regardless of gastrointestinal adverse events.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Urvish K. Patel, Preeti Malik, Dhaivat Shah, Ashish Sharma, Jatminderpal Bhela, Bindi Chauhan, Deepkumar Patel, Nashmia Khan, Ashish Kapoor, Tapan Kavi
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)