Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome

(2020) Guy M. Lenk et al.   ANNALS OF NEUROLOGY

Dravet syndrome: Treatment options and management of prolonged seizures

(2020) J. Helen Cross et al.   EPILEPSIA

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

(2020) Kian Huat Lim et al.   Nature Communications

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

(2020) Zhou Han et al.   Science Translational Medicine

Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

(2019) Kevin M Goff et al.   eLife

dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice

(2019) Gaia Colasante et al.   MOLECULAR THERAPY

Prax330 reduces persistent and resurgent sodium channel currents and neuronal hyperexcitability of subiculum neurons in a mouse model of SCN8A epileptic encephalopathy

(2019) Eric R. Wengert et al.   NEUROPHARMACOLOGY

A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome

(2018) Morgana Favero et al.   JOURNAL OF NEUROSCIENCE

Prominent role of forebrain excitatory neurons in SCN8A encephalopathy

(2018) Rosie K A Bunton-Stasyshyn et al.   BRAIN

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

(2017) Nicole A. Hawkins et al.   Annals of Clinical and Translational Neurology

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

(2016) Richard S Finkel et al.   LANCET

Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome

(2014) C. Tai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnosis and long-term course of Dravet syndrome

(2012) Ingrid E. Scheffer   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility

(2012) Stacey B. Dutton et al.   NEUROBIOLOGY OF DISEASE

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The core Dravet syndrome phenotype

(2011) Charlotte Dravet   EPILEPSIA