Exercise and adrenergic regulation of immunity

Beta-adrenergic blockade blunts inflammatory and antiviral/antibody gene expression responses to acute psychosocial stress

(2021) Jennifer K. MacCormack et al.   NEUROPSYCHOPHARMACOLOGY

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

(2021) Sapna Devi et al.   IMMUNITY

Exercise as a countermeasure for latent viral reactivation during long duration space flight

(2020) Nadia H. Agha et al.   FASEB JOURNAL

Systemic β-Adrenergic Receptor Activation Augments the ex vivo Expansion and Anti-Tumor Activity of Vγ9Vδ2 T-Cells

(2020) Forrest L. Baker et al.   Frontiers in Immunology

The immunological case for staying active during the COVID-19 pandemic

(2020) Richard J. Simpson et al.   BRAIN BEHAVIOR AND IMMUNITY

Glycolysis – a key player in the inflammatory response

(2020) Gonzalo Soto‐Heredero et al.   FEBS Journal

Is Exercise a Match for Cold Exposure? Common Molecular Framework for Adipose Tissue Browning

(2020) Alexandra R. Martin et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

High-intensity interval training in allogeneic adoptive T-cell immunotherapy – a big HIT?

(2020) Nele Carolin Heinemann et al.   Journal of Translational Medicine

The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immune effects of exercise

(2020) Hawley E. Kunz et al.   CELL STRESS & CHAPERONES

Systemic β 1 -Adrenergic Receptor Blockade Augments NK-Cell Mobilization In Response To Acute Exercise In Humans

(2020) Kyle A. Smith et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

β2-Adrenergic receptor activation on donor cells ameliorates acute GvHD

(2020) Hemn Mohammadpour et al.   JCI Insight

Human immune cell mobilization during exercise: effect of IL‐6 receptor blockade

(2020) Marie Lund Bay et al.   EXPERIMENTAL PHYSIOLOGY

Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

(2020) Helene Rundqvist et al.   eLife

Depression stresses the immune response and promotes prostate cancer growth

(2019) Hemn Mohammadpour et al.   CLINICAL CANCER RESEARCH

Adrenergic Modulation of Hematopoiesis

(2019) Georges J. M. Maestroni   Journal of Neuroimmune Pharmacology

Revolutionizing immunology with single-cell RNA sequencing

(2019) Haide Chen et al.   Cellular & Molecular Immunology

C/EBPβ regulates the M2 transcriptome in β-adrenergic-stimulated macrophages

(2019) Donald M. Lamkin et al.   BRAIN BEHAVIOR AND IMMUNITY

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

(2019) Ya-Hsuan Ho et al.   Cell Stem Cell

Physical Exercise and Neuroinflammation in Major Depressive Disorder

(2019) Zuleide M. Ignácio et al.   MOLECULAR NEUROBIOLOGY

Concentric and Eccentric Endurance Exercise Reverse Hallmarks of T-Cell Senescence in Pre-diabetic Subjects

(2019) Marc Philippe et al.   Frontiers in Physiology

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

(2019) Hemn Mohammadpour et al.   JOURNAL OF CLINICAL INVESTIGATION

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

(2019) Vanessa Frodermann et al.   NATURE MEDICINE

Obesity: a neuroimmunometabolic perspective

(2019) Chelsea M. Larabee et al.   Nature Reviews Endocrinology

Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals

(2019) Isabel Gálvez et al.   Nutrients

Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised

(2018) Kari J. Dugger et al.   BMC IMMUNOLOGY

Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β 2 -adrenergic receptor

(2018) Nadia H. Agha et al.   BRAIN BEHAVIOR AND IMMUNITY

GPCR desensitization: Acute and prolonged phases

(2018) Sudarshan Rajagopal et al.   CELLULAR SIGNALLING

The short-term stress response – Mother nature’s mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity

(2018) Firdaus S. Dhabhar   FRONTIERS IN NEUROENDOCRINOLOGY

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

(2018) Grace M. Niemiro et al.   JOURNAL OF PHYSIOLOGY-LONDON

A single exercise bout augments adenovirus-specific T-cell mobilization and function

(2018) Hawley E. Kunz et al.   PHYSIOLOGY & BEHAVIOR

Lymphocytes and monocytes egress peripheral blood within minutes after cessation of steady state exercise: A detailed temporal analysis of leukocyte extravasation

(2018) Bridgette V. Rooney et al.   PHYSIOLOGY & BEHAVIOR

The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence

(2018) Siew-Min Ong et al.   Cell Death & Disease

Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan

(2018) John P. Campbell et al.   Frontiers in Immunology

Meta-analysis of Carvedilol for the Prevention of Anthracycline-Induced Cardiotoxicity

(2018) Babikir Kheiri et al.   AMERICAN JOURNAL OF CARDIOLOGY

EBV/LMP-specific T cells maintain remissions of T and B cell EBV lymphomas after allogeneic bone marrow transplantation

(2018) Lauren P. McLaughlin et al.   BLOOD

β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans

(2018) Rachel M. Graff et al.   BRAIN BEHAVIOR AND IMMUNITY

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion

(2018) Didem Ağaç et al.   BRAIN BEHAVIOR AND IMMUNITY

β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress

(2018) Guanxi Qiao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Human Cytomegalovirus, from Oncomodulation to Oncogenesis

(2018) Georges Herbein   Viruses-Basel

Protective role of beta-blockers in chemotherapy-induced cardiotoxicity—a systematic review and meta-analysis of carvedilol

(2018) Shan Huang et al.   HEART FAILURE REVIEWS

Mobilizing Immune Cells With Exercise for Cancer Immunotherapy

(2017) Richard J. Simpson et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Kinetics of circulating progenitor cell mobilization during submaximal exercise

(2017) Grace M. Niemiro et al.   JOURNAL OF APPLIED PHYSIOLOGY

To block it, or not to block it?

(2017) Artur Wnorowski   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Balancing the autonomic nervous system to reduce inflammation in rheumatoid arthritis

(2017) F. A. Koopman et al.   JOURNAL OF INTERNAL MEDICINE

Human T cell immunosenescence and inflammation in aging

(2017) Arsun Bektas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neurological consequences of obesity

(2017) Phillipe D O'Brien et al.   LANCET NEUROLOGY

Short term exercise training enhances cell-mediated responses to HSV-1 vaccine in mice

(2017) M. Molanouri Shamsi et al.   MICROBIAL PATHOGENESIS

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

(2017) Shuchi Mittal et al.   SCIENCE

GPCR Signaling and Trafficking: The Long and Short of It

(2017) Nathan J. Pavlos et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling

(2017) Jialu Wang et al.   Nature Communications

Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

(2017) Yuwei Jiang et al.   eLife

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

(2017) Kathleen M. Kokolus et al.   OncoImmunology

β-Adrenergic-stimulated macrophages: Comprehensive localization in the M1-M2 spectrum

(2016) Donald M. Lamkin et al.   BRAIN BEHAVIOR AND IMMUNITY

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

(2016) Line Pedersen et al.   Cell Metabolism

Latent cytomegalovirus infection enhances anti-tumour cytotoxicity through accumulation of NKG2C+ NK cells in healthy humans

(2016) A. B. Bigley et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

β-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives

(2016) Marisa Coelho et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Depletion of Neural Crest–Derived Cells Leads to Reduction in Plasma Noradrenaline and Alters B Lymphopoiesis

(2016) Naoki Tsunokuma et al.   JOURNAL OF IMMUNOLOGY

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

Exercise Training Alleviates Hypoxia-induced Mitochondrial Dysfunction in the Lymphocytes of Sedentary Males

(2016) Hsing-Hua Tsai et al.   Scientific Reports

A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy

(2016) Guillaume Spielmann et al.   Scientific Reports

Sympathetic neural adaptations to exercise training in humans

(2015) Jason R. Carter et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Beta-adrenergic receptor mediated inflammation control by monocytes is associated with blood pressure and risk factors for cardiovascular disease

(2015) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation

(2015) Christina Slota et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Part II: Impact of latent cytomegalovirus infection and catecholamine sensitivity

(2015) Austin B. Bigley et al.   BRAIN BEHAVIOR AND IMMUNITY

Progenitor cells are mobilized by acute psychological stress but not beta-adrenergic receptor agonist infusion

(2015) Natalie E. Riddell et al.   BRAIN BEHAVIOR AND IMMUNITY

Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system

(2015) Mark A. Barnes et al.   CYTOKINE

Peripheral and central effects of repeated social defeat stress: Monocyte trafficking, microglial activation, and anxiety

(2015) B.F. Reader et al.   NEUROSCIENCE

The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man

(2015) Austin B. Bigley et al.   Oxidative Medicine and Cellular Longevity

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

(2015) B. K. Pedersen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Differential β2-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines

(2015) Lucía Gargiulo et al.   Oncotarget

Proinflammatory status influences NK cells subsets in the elderly

(2014) Carmen Campos et al.   IMMUNOLOGY LETTERS

Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors

(2014) Akiko Nakai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of M2 Regulatory Macrophages through the �2-Adrenergic Receptor with Protection during Endotoxemia and Acute Lung Injury

(2014) Jamison J. Grailer et al.   Journal of Innate Immunity

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Neuroendocrine regulation of inflammation

(2014) Caroline J. Padro et al.   SEMINARS IN IMMUNOLOGY

Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

(2013) James E. Turner et al.   AGE

β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle

(2013) Sang Hyun Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Aging affects AO rat splenic conventional dendritic cell subset composition, cytokine synthesis and T-helper polarizing capacity

(2013) Zorica Stojić-Vukanić et al.   BIOGERONTOLOGY

Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells

(2013) Austin B. Bigley et al.   BRAIN BEHAVIOR AND IMMUNITY

The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans

(2013) Guillaume Spielmann et al.   BRAIN BEHAVIOR AND IMMUNITY

Benefit of physical fitness against inflammation in obesity: Role of beta adrenergic receptors

(2013) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

The immune cells in adipose tissue

(2013) A. W. Ferrante   DIABETES OBESITY & METABOLISM

Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via  -adrenergic induction of myelopoiesis

(2013) N. D. Powell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catecholamines and Obesity: Effects of Exercise and Training

(2013) Hassane Zouhal et al.   SPORTS MEDICINE

Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective

(2013) Harris A. Eyre et al.   Frontiers in Psychiatry

Effects of Exercise and Physical Activity on Anxiety

(2013) Elizabeth Anderson et al.   Frontiers in Psychiatry

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

(2012) Christoph Scheiermann et al.   IMMUNITY

High-Intensity Training Reduces CD8+ T-cell Redistribution in Response to Exercise

(2012) OLIVER C. WITARD et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Stress-induced redistribution of immune cells—From barracks to boulevards to battlefields: A tale of three hormones – Curt Richter Award Winner

(2012) Firdaus S. Dhabhar et al.   PSYCHONEUROENDOCRINOLOGY

Aerobic fitness is associated with lower proportions of senescent blood T-cells in man

(2011) Guillaume Spielmann et al.   BRAIN BEHAVIOR AND IMMUNITY

NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection

(2011) Austin B. Bigley et al.   BRAIN BEHAVIOR AND IMMUNITY

National Prevalence Estimates for Cytomegalovirus IgM and IgG Avidity and Association between High IgM Antibody Titer and Low IgG Avidity

(2011) Sheila C. Dollard et al.   Clinical and Vaccine Immunology

The narrowing of the CD8 T cell repertoire in old age

(2011) Marcia A Blackman et al.   CURRENT OPINION IN IMMUNOLOGY

Leukocyte β2-Adrenergic Receptor Expression in Response to Resistance Exercise

(2011) MAREN S. FRAGALA et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

(2011) James B. Strait et al.   Heart Failure Clinics

Aging, Persistent Viral Infections, and Immunosenescence

(2010) Richard J. Simpson   EXERCISE AND SPORT SCIENCES REVIEWS

Central sympathetic overactivity: Maladies and mechanisms

(2009) James P. Fisher et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Mobilization of γδ T lymphocytes in response to psychological stress, exercise, and β-agonist infusion

(2009) Leila H. Anane et al.   BRAIN BEHAVIOR AND IMMUNITY

Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors

(2009) J. A. Meyers et al.   JOURNAL OF IMMUNOLOGY

Selective Mobilization of Cytotoxic Leukocytes by Epinephrine

(2009) Stoyan Dimitrov et al.   JOURNAL OF IMMUNOLOGY

Exercise as a Mean to Control Low-Grade Systemic Inflammation

(2009) Neha Mathur et al.   MEDIATORS OF INFLAMMATION

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection and Immunopathology

(2009) Firdaus S. Dhabhar   NEUROIMMUNOMODULATION

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

(2009) María Pita-Lopez et al.   Immunity & Ageing

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise

(2008) Richard J. Simpson et al.   BRAIN BEHAVIOR AND IMMUNITY

Systemic administration of leptin decreases plasma corticosterone levels: Role of hypothalamic norepinephrine

(2008) Kimberly A. Clark et al.   BRAIN RESEARCH

Neuroendocrine factors alter host defense by modulating immune function

(2008) Cherie L. Butts et al.   CELLULAR IMMUNOLOGY

Short-term β-adrenergic regulation of leptin, adiponectin and interleukin-6 secretionin vivoin lean and obese subjects

(2008) G. H. Goossens et al.   DIABETES OBESITY & METABOLISM

Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ

(2008) I. Murano et al.   JOURNAL OF ANATOMY

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms

(2007) K. Krüger et al.   BRAIN BEHAVIOR AND IMMUNITY

Mood states, sympathetic activity, and in vivo β-adrenergic receptor function in a normal population

(2007) Bum-Hee Yu et al.   DEPRESSION AND ANXIETY