Article
Hematology
Boris van der Zouwen, E. A. S. Koster, P. A. von dem Borne, L. E. M. Oosten, M. W. I. Roza-Scholten, T. J. F. Snijders, D. van Lammeren, P. van Balen, W. A. F. Marijt, H. Veelken, J. H. F. Falkenburg, L. C. de Wreede, C. J. M. Halkes
Summary: Prophylactic donor lymphocyte infusion (DLI) can introduce graft-versus-leukemia (GvL) effects with low risk of severe graft-versus-host-disease (GvHD) when initiated at 6 months after T cell-depleted allogeneic stem cell transplantation (TCD-alloSCT). This study retrospectively analyzed the use of low-dose early DLI at 3 months after alloSCT to prevent early relapse.
ANNALS OF HEMATOLOGY
(2023)
Article
Biophysics
Luxin Yang, Xiaoyu Lai, Ting Yang, Ying Lu, Lizhen Liu, Jimin Shi, Yanmin Zhao, Yibo Wu, Yi Chen, Jian Yu, Haowen Xiao, Guifang Ouyang, Jinhua Ren, Junjie Cao, Yongxian Hu, Yamin Tan, Yishan Ye, Zhen Cai, Weiqun Xu, He Huang, Yi Luo
Summary: This study compared the effectiveness of prophylactic modified DLI (pro-DLI) and preemptive modified DLI (pre-DLI) in patients with high-risk relapse features acute leukemia. The results showed that the pro-DLI group had higher 3-year progression-free survival and overall survival compared to the pre-DLI group. The cumulative incidence of relapse was also significantly lower in the pro-DLI group. Therefore, early scheduled pro-DLI could reduce post-transplant relapse and improve long-term survival in high-risk acute leukemia patients.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Katrin Teich, Michael Stadler, Razif Gabdoulline, Jyoti Kandarp, Clara Wienecke, Bennet Heida, Piroska Klement, Konstantin Buttner, Letizia Venturini, Martin Wichmann, Wolfram Puppe, Christian Schultze-Florey, Christian Koenecke, Gernot Beutel, Matthias Eder, Arnold Ganser, Michael Heuser, Felicitas Thol
Summary: Donor lymphocyte infusions (DLIs) can be used to prevent or treat relapse in acute myeloid leukemia (AML) patients after allogeneic hematopoietic cell transplantation (alloHCT). Measurable residual disease (MRD) is a valuable biomarker for predicting the response and outcome of DLI treatment. This retrospective study showed that MRD status before and after DLI treatment is prognostic for event-free survival, overall survival, cumulative incidence of relapse, and relapse-free survival.
Article
Immunology
Eva A. S. Koster, Edouard F. Bonneville, Peter A. von dem Borne, Peter van Balen, Erik W. A. Marijt, Jennifer M. L. Tjon, Tjeerd J. F. Snijders, Danielle van Lammeren, Hendrik Veelken, Hein Putter, J. H. Frederik Falkenburg, Constantijn J. M. Halkes, Liesbeth C. de Wreede
Summary: Alloreactive donor-derived T-cells play a crucial role in alloimmune responses after allogeneic hematopoietic stem cell transplantation (alloSCT), affecting both the prevention of leukemia relapse and the risk of graft-versus-host disease (GvHD). This study investigates the complex associations between T-cell kinetics and alloimmune responses in acute leukemia patients receiving alemtuzumab-based T-cell depletion alloSCT. The results demonstrate that donor lymphocyte infusion (DLI) can lead to detectable T-cell expansion, with CD4+ T-cells showing the strongest association with the development of alloimmune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Qiongqiong Su, Zhiping Fan, Fen Huang, Na Xu, Danian Nie, Dongjun Lin, Ziwen Guo, Pengcheng Shi, Zhixiang Wang, Ling Jiang, Jing Sun, Zujun Jiang, Qifa Liu, Li Xuan
Summary: Delaying prophylactic donor lymphocyte infusion (pDLI) to day +90 based on minimal residual disease (MRD) for patients with refractory/relapsed acute leukemia undergoing allo-HSCT could reduce extensive chronic GVHD incidence and improve GVHD-free/relapse-free survival (GRFS) without increasing the risk of leukemia relapse.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Kaito Harada, Shohei Mizuno, Shingo Yano, Akiyoshi Takami, Hiroto Ishii, Kazuhiro Ikegame, Yuho Najima, Shinichi Kako, Takashi Ashida, Souichi Shiratori, Shuichi Ota, Makoto Onizuka, Kentaro Fukushima, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Masamitsu Yanada
Summary: Although haploidentical donor lymphocyte infusion (DLI) is a valid treatment option for relapsed acute myeloid leukemia (AML), the incidence and risk factors for graft-versus-host disease (GVHD) and the efficacy of haploidentical DLI have not been fully evaluated. Our retrospective analysis showed that a higher CD3(+) cell count was associated with an increased risk of acute GVHD, and preemptive DLI resulted in better overall response.
ANNALS OF HEMATOLOGY
(2022)
Article
Oncology
Panagiotis Tsirigotis, Konstantinos Gkirkas, Vassiliki Kitsiou, Spiros Chondropoulos, Theofilos Athanassiades, Thomas Thomopoulos, Alexandra Tsirogianni, Maria Stamouli, Aggeliki Karagiannidi, Nikolaos Siafakas, Vassiliki Pappa, Arnon Nagler
Summary: The study demonstrates that prolonged up to three years of low-dose pro-DLI administered every two months is safe and effective in reducing relapse rate in patients with high-risk acute leukemia. The strategy of low-dose repetitive administration DLI reduces the risk of GVHD and helps in preventing relapse by inducing sustained immunological pressure on residual leukemic cells. Further testing in larger cohorts is warranted to confirm the efficacy of this novel approach in high-risk acute leukemia patients.
Article
Oncology
Tingting Han, Yuqian Sun, Yang Liu, Chenhua Yan, Yu Wang, Lanping Xu, Kaiyan Liu, Xiaojun Huang, Xiaohui Zhang
Summary: This study retrospectively analyzed the efficacy of a second allogeneic hematopoietic stem cell transplantation (HSCT2) in 28 patients with relapsed/refractory acute leukemia after chemotherapy plus modified donor lymphocyte infusion following the first allo-HSCT (HSCT1). The findings showed a high rate of complete remission in patients post-HSCT2, with overall survival (OS) and disease-free survival (DFS) rates at 1 year post-HSCT2 being 25.0% and 21.4%, respectively. Risk factors for OS post-HSCT2 included risk stratification prior to HSCT1 and blast percentage before HSCT2, while relapse within 6 months post-HSCT1 was a risk factor for DFS and relapse post-HSCT2. The study suggests that HSCT2 could be a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor lymphocyte infusion.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Raynier Devillier, Boris Calmels, Sophie Guia, Mohammed Taha, Cyril Fauriat, Bechara Mfarrej, Geoffroy Venton, Eric Vivier, Daniel Olive, Christian Chabannon, Didier Blaise, Sophie Ugolini
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective curative option for high-risk hematologic malignancies, but disease recurrence remains a critical issue. NK cell-based immunotherapies offer a promising approach to enhance anti-tumor effects without triggering graft-versus-host disease. This clinical trial demonstrates the safety and potential efficacy of prophylactic donor-derived IL-2 activated NK cell infusion after allo-HSCT for patients with hematologic malignancies.
Article
Hematology
Kaito Harada
Summary: Donor lymphocyte infusion (DLI) is an allogenic immunotherapy used after allogeneic hematopoietic stem cell transplantation to prevent relapse or as maintenance therapy. DLI takes advantage of the graft-versus-tumor effect but can also lead to graft-versus-host disease. The response and efficacy of DLI depend on various factors, including patient, disease, and DLI factors.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Takayuki Inoue, Motoko Koyama, Katsuji Kaida, Kazuhiro Ikegame, Kathleen S. Ensbey, Luke Samson, Shuichiro Takahashi, Ping Zhang, Simone A. Minnie, Satoshi Maruyama, Shinichi Ishii, Takashi Daimon, Takahiro Fukuda, Hirohisa Nakamae, Takahide Ara, Yumiko Maruyama, Ken Ishiyama, Tatsuo Ichinohe, Yoshiko Atsuta, Bruce R. Blazar, Scott N. Furlan, Hiroyasu Ogawa, Geoffrey R. Hill
Summary: Administration of glucocorticoids before and after haplo-identical hematopoietic stem cell transplantation can effectively inhibit graft-versus-host disease, reduce relapse rates, and improve survival outcomes in patients with acute leukemia.
Article
Hematology
Thierry Guillaume, Sylvain Thepot, Pierre Peterlin, Patrice Ceballos, Amandine Le Bourgeois, Alice Garnier, Corentin Orvain, Aurelien Giltat, Sylvie Francois, Yannick Le Bris, Clementine Fronteau, Lucie Planche, Patrice Chevallier
Summary: This study retrospectively analyzed the effects of AZA or AZA combined with DLL post-transplantation maintenance therapy in high-risk AML or MDS patients, showing that this treatment approach is tolerable and effective in reducing the risk of post-transplantation relapse.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Article
Oncology
Xuefeng Li, Wen Wang, Xin Zhang, Yu Wu
Summary: The regimen of azacitidine and donor lymphocyte infusion (DLI) can safely improve the outcomes of relapsed acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), especially in patients with signs of early relapse. The administration of targeted medicines in azacitidine-based therapies may further improve the outcomes of relapsed AML/MDS.
FRONTIERS IN ONCOLOGY
(2022)
Article
Hematology
Michael Stadler, Lothar Hambach, Elke Dammann, Helmut Diedrich, Haytham Kamal, Iyas Hamwi, Christian Schultze-Florey, Michael Varvenne, Steve Ehrlich, Stefanie Buchholz, Christian Koenecke, Gernot Beutel, Eva M. Weissinger, Juergen Krauter, Matthias Eder, Bernd Hertenstein, Arnold Ganser
Summary: Prophylactic donor lymphocyte infusions (proDLI) can prevent leukemia relapse after alloSCT. This study found that proDLI applied beyond day +120 post alloSCT can improve overall survival, disease-free survival, and reduce relapse incidence and non-relapse mortality in high-risk AL or MDS patients.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Premal D. Lulla, Swati Naik, Spyridoula Vasileiou, Ifigeneia Tzannou, Ayumi Watanabe, Manik Kuvalekar, Suhasini Lulla, George Carrum, Carlos A. Ramos, Rammurti Kamble, LaQuisa Hill, Jasleen Randhawa, Stephen Gottschalk, Robert Krance, Tao Wang, Mengfen Wu, Catherine Robertson, Adrian P. Gee, Betty Chung, Bambi Grilley, Malcolm K. Brenner, Helen E. Heslop, Juan F. Vera, Ann M. Leen
Summary: Leukemia-specific T cells (mLSTs) selectively recognized and killed leukemia antigen-pulsed cells in vitro, showing no activity against recipient's normal cells. Infusions of mLSTs were well tolerated with no severe GVHD, leading to antileukemia effects and promising outcomes for AML/MDS patients after HCT.
Letter
Hematology
Annalisa Ruggeri, Liesbeth C. de Wreede, Carlheinz R. Muller, Pietro Crivello, Edouard F. Bonneville, Effie W. Petersdorf, Gerard Socie, Valerie Dubois, Riitta Niittyvuopio, Juha Perasaari, Ibrahim Yakoub-Agha, Jan J. Cornelissen, Lotte Wieten, Tobias Gedde-Dahl, Edouard Forcade, Charles R. Crawley, Steven G. E. Marsh, Virginie Gandemer, Eleni Tholouli, Claude-Eric Bulabois, Anne Huynh, Goda Choi, Eric Deconinck, Maija Itala-Remes, Stig Lenhoff, Mats Bengtsson, Jan-Erik Johansson, Gwendolyn van Gorkom, Jorinde D. Hoogenboom, Luca Vago, Vanderson Rocha, Chiara Bonini, Christian Chabannon, Katharina Fleischhauer
Article
Hematology
Sarah Lawless, Simona Iacobelli, Nina Simone Knelange, Patrice Chevallier, Didier Blaise, Noel Milpied, Roberto Foa, Jan J. Cornelissen, Bruno Lioure, Ruben Benjamin, Xavier Poire, Monique C. Minnema, Matthew Collin, Stig Lenhoff, John A. Snowden, Stella Santarone, Keith M. O. Wilson, Fernanda Trigo, Peter Dreger, Lara H. Bohmer, Hein Putter, Laurent Garderet, Nicolaus Kroeger, Ibrahim Yaukoub-Agha, Stefan Schonland, Curly Morris
Summary: This retrospective analysis studied 751 patients with primary plasma cell leukemia (pPCL) undergoing different transplant strategies. The results showed that tandem transplant strategies were more effective than single transplant strategies. Additionally, the disease status at the time of transplant influenced the outcomes.
Article
Oncology
Arnon Nagler, Jacques-Emmanuel Galimard, Myriam Labopin, Didier Blaise, William Arcese, Silvia Maria Trisolini, Depei Wu, Arnaud Pigneux, Gwendolyn Van Gorkom, Marie-Therese Rubio, Tobias Gedde-Dahl, Anne Huynh, Francesco Lanza, Norbert-Claude Gorin, Mohamad Mohty
Summary: AML patients who required two chemotherapy courses to achieve complete remission had inferior leukemia free survival and overall survival rates, as well as higher relapse incidence. Allogeneic transplantation may be a better option for these patients to improve outcomes.
Editorial Material
Hematology
Jean-Luc Harousseau, Mohamad Mohty
Article
Hematology
Anais Schavgoulidze, Alexis Talbot, Aurore Perrot, Titouan Cazaubiel, Xavier Leleu, Salomon Manier, Laure Buisson, Sabrina Maheo, Laura Do Souto Ferreira, Luka Pavageau, Cyrille Hulin, Jean-Pierre Marolleau, Laurent Voillat, Karim Belhadj, Marion Divoux, Borhane Slama, Sabine Brechignac, Margaret Macro, Anne-Marie Stoppa, Laurence Sanhes, Frederique Orsini-Piocelle, Jean Fontan, Marie-Lorraine Chretien, Helene Demarquette, Mohamad Mohty, Herve Avet-Loiseau, Jill Corre
Summary: Our study aimed to confirm the adverse effect of 1p32 deletion in patients with newly diagnosed multiple myeloma (NDMM). We found that patients with del(1p32) had significantly inferior overall survival and progression-free survival compared to those without del(1p32). Biallelic del(1p32) conferred a dramatically poorer prognosis than monoallelic del(1p32).
Review
Medicine, Research & Experimental
Imre Bodo, Ismail Amine, Ana Boban, Horia Bumbea, Alexander Kulagin, Elena Lukina, Agnieszka Piekarska, Irena Preloznik Zupan, Juraj Sokol, Jerzy Windyga, Jaroslav Cermak
Summary: Hemolysis in PNH is complement-mediated due to the lack of complement inhibitors in the cell membranes. To manage PNH, complement inhibition is the best approach. Three complement inhibitors – eculizumab, ravulizumab, and pegcetacoplan – are approved as targeted therapy for PNH. However, current guidelines do not consider the latest clinical trial evidence. Expert recommendations were created to identify specific populations who may benefit from switching to proximal C3 inhibition.
ADVANCES IN THERAPY
(2023)
Review
Hematology
David Dingli, Jaroslaw P. Maciejewski, Loree Larratt, Ronald S. Go, Britta Hoechsmann, Ke Zu, Philippe Gustovic, Alexander D. Kulagin
Summary: This study investigated the relationship between the proportion of GPI-deficient granulocytes at PNH onset and the risk for major adverse vascular events (MAVEs) and other parameters at last follow-up. It found that a higher proportion of GPI-deficient granulocytes at baseline was associated with increased risk of MAVEs, high disease activity, elevated lactate dehydrogenase (LDH) ratio, and higher rates of MAVEs and thrombotic events (TEs). Fatigue was present in most patients, while abdominal pain was more frequently reported with larger clone size. These findings suggest that baseline clone size can indicate disease burden and risk of MAVEs and TEs in PNH patients.
ANNALS OF HEMATOLOGY
(2023)
Article
Biophysics
Klaus Hirschbuehl, Myriam Labopin, Emmanuelle Polge, Didier Blaise, Jean Henri Bourhis, Gerard Socie, Edouard Forcade, Ibrahim Yakoub-Agha, Helene Labussiere-Wallet, Wolfgang Bethge, Patrice Chevallier, Sarah Bonnet, Matthias Stelljes, Alexandros Spyridonidis, Zinaida Peric, Eolia Brissot, Bipin Savani, Sebastian Giebel, Christoph Schmid, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Summary: Allogeneic hematopoietic cell transplantation is a curative treatment for high-risk acute lymphoblastic leukemia, and conditioning regimens based on 12 Gray total body irradiation are the standard for patients under 45 years old. However, elderly patients often receive intermediate intensity conditioning to reduce toxicity. A retrospective study compared the outcomes of different conditioning regimens in ALL patients over 45 years old.
BONE MARROW TRANSPLANTATION
(2023)
Article
Biophysics
Iman Abou Dalle, Myriam Labopin, Nicolaus Kroeger, Thomas Schroeder, Juergen Finke, Matthias Stelljes, Andreas Neubauer, Didier Blaise, Ibrahim Yakoub-Agha, Urpu Salmenniemi, Edouard Forcade, Maija Itala-Remes, Peter Dreger, Gesine Bug, Jakob Passweg, Michael Heuser, Goda Choi, Eolia Brissot, Sebastian Giebel, Arnon Nagler, Fabio Ciceri, Ali Bazarbachi, Mohamad Mohty
Summary: Pre-transplant detectable measurable residual disease (MRD) is still associated with high risk of relapse and poor outcomes in acute myeloid leukemia (AML). The impact of disease burden on prediction of relapse and survival in patients receiving allogeneic hematopoietic cell transplantation (allo-HCT) in first remission (CR1) was evaluated. The study found that patients in CR1 and MRD positive at time of transplant could still be salvaged by allo-HCT, with significantly better outcomes than patients transplanted with active disease.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Rama Al Hamed, Maud Ngoya, Jacques-Emmanuel Galimard, Henrik Sengeloev, Tobias Gedde-Dahl, Aleksandr Kulagin, Uwe Platzbecker, Ibrahim Yakoub-Agha, Jenny L. Byrne, Thomas Valerius, Gerard Socie, Nicolaus Kroeger, Didier Blaise, Ali Bazarbachi, Jaime Sanz, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Summary: This retrospective study investigates the impact of time on allogeneic hematopoietic cell transplantation (allo-HCT) outcomes for patients with acute myeloid leukemia (AML) in second complete remission (CR2). The results show that outcomes of allo-HCT in CR2 have significantly improved over time, with the most favorable outcomes achieved with a matched sibling donor (MSD).
Letter
Oncology
Frederic Baron, Myriam Labopin, Johanna Tischer, Anna Maria Raiola, Jan Vydra, Didier Blaise, Patrizia Chiusolo, Friedrich Stoelzel, Renato Fanin, Patrice Chevallier, Arnon Nagler, Fabio Ciceri, Mohamad Mohty
Summary: A study on the association between the occurrence of GVHD and the relapse of AML in patients undergoing Haplo-HCT with PTCy-based GVHD prophylaxis found that while grade I acute GVHD was associated with better LFS, grade III-IV acute and extensive chronic GVHD were correlated with higher nonrelapse mortality and lower LFS.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Medicine, General & Internal
Florent Malard, Ernst Holler, Brenda M. Sandmaier, He Huang, Mohamad Mohty
Summary: Acute graft-versus-host disease (GVHD) is a common immune complication that can occur after allogeneic haematopoietic cell transplantation (alloHCT). This Primer summarizes the epidemiology, pathophysiology, diagnosis, prevention and treatment of this disorder. The article also reviews future research avenues and the effect this disorder has on patients' quality of life.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Letter
Hematology
Marie Robin, Liesbeth C. de Wreede, Thomas Schroeder, Friedrich Stoelzel, Nicolaus Kroeger, Linda Koster, Uwe Platzbecker, Juergen Finke, Arnold Ganser, Didier Blaise, Fabio Ciceri, Johan Maertens, Helene Labussiere Wallet, Junfeng Wang, Patrice Chevallier, Jakob Passweg, Jan J. Cornelissen, Stephanie Nguyen, Edouard Forcade, Amandine Charbonnier, Francesca Bonifazi, Patrick Hayden, Donal P. McLornan, Ibrahim Yakoub-Agha
Correction
Oncology
Arnon Nagler, Myriam Labopin, Didier Blaise, Anna Maria Raiola, Lucia Lopez Corral, Stefania Bramanti, Simona Sica, Mi Kwon, Yener Koc, Jiri Pavlu, Alexander Kulagin, Alessandro Busca, Arancha Bermudez Rodriguez, Peter Remenyi, Christoph Schmid, Eolia Brissot, Jaime Sanz, Ali Bazarbachi, Sebastian Giebel, Fabio Ciceri, Mohamad Mohty
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Vincent Jachiet, Laure Ricard, Pierre Hirsch, Florent Malard, Laurent Pascal, Odile Beyne-Rauzy, Pierre Peterlin, Alexandre Thibault Jacques Maria, Norbert Vey, Maud D'Aveni, Marie-Pierre Gourin, Sophie Dimicoli-Salazar, Anne Banos, Stefan Wickenhauser, Louis Terriou, Benoit De Renzis, Eric Durot, Shanti Natarajan-Ame, Anne Vekhoff, Laurent Voillat, Sophie Park, Julien Vinit, Celine Dieval, Azeddine Dellal, Vincent Grobost, Lise Willems, Julien Rossignol, Eric Solary, Olivier Kosmider, Nicolas Dulphy, Lin Pierre Zhao, Lionel Ades, Pierre Fenaux, Olivier Fain, Mohamad Mohty, Beatrice Gaugler, Arsene Mekinian
Summary: Background systemic inflammatory and autoimmune diseases (SIADs) occur in a significant proportion of myelodysplastic syndrome (MDS) patients. The recently identified VEXAS syndrome, associated with somatic mutations in UBA1, is characterized by severe inflammatory conditions and hematological abnormalities, including MDS. However, the mechanisms underlying the association between MDS and SIADs are largely unknown. This study aimed to evaluate myeloid immune cell subsets in MDS patients with and without SIAD and compare them to healthy controls.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)