Article
Multidisciplinary Sciences
Thea C. Heil, Rene J. F. Melis, Huub A. A. M. Maas, Barbara C. van Munster, Marcel G. M. Olde Rikkert, Johannes H. W. de Wilt, Eddy M. M. Adang
Summary: This study found significant technical efficiency variation in preoperative colorectal cancer care for older patients provided by Dutch hospitals. Offering a care pathway that includes prehabilitation was positively related to technical efficiency, especially in high-volume hospitals and general hospitals.
Article
Surgery
Joel E. Lambert, Lawrence D. Hayes, Thomas J. Keegan, Daren A. Subar, Christopher J. Gaffney
Summary: Prehabilitation was associated with reduced hospital length of stay but had no effect on functional capacity, postoperative complications, or mortality rates in patients undergoing surgery for hepatobiliary, colorectal, and upper gastrointestinal cancer.
Article
Surgery
Aron Onerup, John Andersson, Eva Angenete, David Bock, Mats Borjesson, Carolina Ehrencrona, Monika Fagevik Olsen, Per-Anders Larsson, Hanna de la Croix, Anette Wedin, Eva Haglind
Summary: This study aimed to determine the effect of a short-term, unsupervised exercise intervention before and after colorectal cancer surgery on self-assessed physical recovery. The results showed no significant difference in self-assessed physical recovery between the intervention group and the control group. Therefore, the current recommendations for preoperative exercise interventions need to be reconsidered.
Article
Oncology
Severin Schmid, Enrico Maria Minnella, Yohann Pilon, Merav Rokah, Roni Rayes, Sara Najmeh, Jonathan Cools-Lartigue, Lorenzo Ferri, David Mulder, Christian Sirois, Scott Owen, Benjamin Shieh, Linda Ofiara, Annick Wong, Shelly Sud, Gabriele Baldini, Francesco Carli, Jonathan Spicer
Summary: This proof-of-concept study analyzed non-small-cell lung cancer patients who underwent simultaneous prehabilitation and neoadjuvant therapy. The results showed that neoadjuvant prehabilitation therapy is feasible and associated with encouraging results.
CLINICAL LUNG CANCER
(2022)
Review
Medicine, General & Internal
Hiromichi Maeda, Michiko Takahashi, Satoru Seo, Kazuhiro Hanazaki
Summary: Frailty is characterized by reduced physiological reserves across multiple systems. In patients with frailty, oncological surgery has been associated with a high rate of postoperative complications and worse overall survival. Cancer and frailty can co-exist in the same patient and accelerate the progression of frailty, termed cancer frailty. The distinction is clinically meaningful because treatment priorities and outcomes may vary based on health conditions, with surgical removal of tumors being more effective in improving frailty in patients with cancer frailty.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Iona Pearson, Sue Blackwell, Rebecca Fish, Sarah Daniels, Malcolm West, Nanette Mutrie, P. Kelly, Stephen Knight, Nicola S. Fearnhead, Susan Moug
Summary: Introduction of prehabilitation in colorectal surgery is growing and may reduce postoperative morbidity and mortality. However, there is significant variability in reported primary endpoints, limited work on patient-related outcome measures, and lack of consensus on key standards. This study aims to address these issues by identifying key standards through a systematic review and patient involvement, followed by a Delphi process and consensus meeting to define final standards.
Review
Cardiac & Cardiovascular Systems
Julia N. Rickard, Arun Eswaran, Stephanie D. Small, Alis Bonsignore, Maureen Pakosh, Paul Oh, Amy A. Kirkham
Summary: Exercise-based, multimodal rehabilitation programs for individuals with cancer, although showed significant improvements in cardiorespiratory fitness and quality of life, have room for improvement in addressing nutrition, psychosocial concerns, and risk factor management. These programs had limited impact on blood pressure, body mass index, and lung function, highlighting the need for a more holistic approach to cancer rehabilitation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Oncology
Kelly Wade-Mcbane, Alex King, Catherine Urch, Julian Jeyasingh-Jacob, Andrew Milne, Clair Le Boutillier
Summary: Based on the review of primary research, a standardized prehabilitation program for lung cancer patients is currently lacking. Future programs should consider factors such as patient values, needs, goals, support structures, and beliefs, as they can influence intervention delivery and engagement. Furthermore, future research should consider using a conceptual framework to conceptualize the experience of living with and beyond cancer, in order to shape and inform personalized prehabilitation services.
Review
Oncology
Pedro Machado, Sara Pimenta, Barbara Oliveiros, Jose Pedro Ferreira, Raul A. Martins, Joana Cruz
Summary: Surgical treatment affects health-related quality of life (HRQoL) and increases fatigue symptoms in patients with lung cancer (LC) and colorectal cancer (CRC). Exercise training improves physical function and reduces fatigue after lung cancer surgery, but shows no significant effects after colorectal cancer surgery. Further research is needed to clarify the impact of exercise on HRQoL and fatigue in colorectal cancer patients post-surgery.
Review
Oncology
Augustinas Bausys, Marius Kryzauskas, Vilius Abeciunas, Austeja Elzbieta Degutyte, Rimantas Bausys, Kestutis Strupas, Tomas Poskus
Summary: Surgical resection is the primary treatment for colorectal cancer, but it is associated with high postoperative morbidity and mortality. Some patients require preoperative neoadjuvant therapy, which increases surgical risk. Prehabilitation is a novel approach to improve patients' physical and psychological capacity and reduce postoperative morbidity.
Review
Oncology
Danielle Coderre, Priya Brahmbhatt, Tracey Louise Hunter, Jennifer Baima
Summary: This article reviews recent controversies in cancer prehabilitation, including efficacy, dose, cost effectiveness, stakeholder input, and international implementation. Recent findings suggest that high intensity exercise is recommended and patients are interested in and willing to attend cancer prehabilitation.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Oncology
Heleen C. van der Hulst, Esther Bastiaannet, Johanna E. A. Portielje, Jessica M. van der Bol, Jan Willem T. Dekker
Summary: Physical prehabilitation shows potential in preventing postoperative complications in frail CRC patients, even though patients selected for prehabilitation had a worse frailty profile. The overall postoperative complication rate did not increase, suggesting that physical prehabilitation may be beneficial in preventing postoperative complications in frail CRC patients over 70 years old.
Article
Anesthesiology
S. L. Harrison, K. J. Loughran, J. Trevis, P. Witharana, R. Maier, H. Hancock, M. Bardgett, A. Mathias, E. F. Akowuah
Summary: The purpose of this study was to understand the views and experiences of patients and staff involved in a cardiac surgery trial. Patients assigned to both the intervention and control groups were invited to participate in focus groups, and the findings identified five themes: preparedness for surgery reduced fear, staff were concerned but patients felt safe, both groups wanted to mobilise quickly postoperatively, staff and patients had expectations for postoperative recovery, and waiting periods diluted the benefits. The results offer valuable recommendations for refining a prehabilitation intervention and conducting a subsequent trial.
Article
Gastroenterology & Hepatology
Cintia Kimura, Yuning Liu, Sarah E. Crowder, Carlie Arbaugh, Uyen Mai, Kreeti Shankar, Andrew Shelton, Brendan Visser, Cindy Kin
Summary: This study aimed to identify barriers and facilitators to prehabilitation adherence among patients undergoing abdominal surgery. The most frequent barriers to exercise and healthy eating were medical issues and lack of motivation, respectively. Higher barriers to healthy eating scores were associated with lower Mediterranean diet scores.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Cristiany M. Paulo, Adil A. Ali, Benjamin N. Schmeusser, Eric Midenberg, Talia A. Helman, Maggie L. Diller, Martijn F. Pisters, Kenneth Ogan, Viraj A. Master
Summary: This study investigated the barriers and facilitators to physical activity prehabilitation in patients undergoing nephrectomy. The results showed that mental factors, personal responsibilities, physical capacity, health conditions, and lack of exercise facilities were the main barriers, while holistic health, social and professional support, acknowledgment of health benefits, and exercise type and guidance were identified as facilitators.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Medicine, General & Internal
Caitlin Notley, Lucy Clark, Pippa Belderson, Emma Ward, Allan B. Clark, Steve Parrott, Sanjay Agrawal, Ben M. Bloom, Adrian A. Boyle, Geraint Morris, Alasdair Gray, Tim Coats, Mei-See Man, Linda Bauld, Richard Holland, Ian Pope
Summary: This study aims to determine whether an opportunistic smoking cessation intervention delivered in the emergency department can help daily smokers quit smoking and is cost-effective. The trial compares brief smoking cessation advice with provision of an e-cigarette and referral to local stop smoking services (intervention group) and provision of contact details for local stop smoking services (control group). Outcomes will be collected at 1, 3, and 6 months, with the primary outcome being carbon monoxide verified continuous smoking abstinence at 6 months.
Article
Medicine, General & Internal
Toby Smith, Reema Khoury, Polly-Anna Ashford, Sarah Hanson, Allie Welsh, Allan B. Clark, Emma Dures, Jo Adams
Summary: This study aims to assess the feasibility and acceptability of a program (JOINT SUPPORT) designed to support individuals with chronic musculoskeletal pain and their caregivers. The program includes group-based training sessions and telephone support, delivered by trained professionals. A mixed-methods feasibility randomized controlled trial will be conducted to evaluate the clinical and cost-effectiveness of the program.
Article
Medicine, General & Internal
Iain McNamara, Valerie Pomeroy, Allan B. Clark, Graham Creelman, Celia Whitehouse, J. Wells, B. Harry, Toby O. Smith, Juliet High, Ann Marie Swart, Celia Clarke
Summary: In this study, there was no difference in patient-reported outcomes scores and biomechanical outcomes between a newer design of total knee replacement (Journey II BCS) and an older design (Genesis II) at 6 months after surgery.
Article
Clinical Neurology
Toby Smith, Michael Mansfield, Sarah Hanson, Allie Welsh, Reema Khoury, Allan Clark, Emma Dures, Jo Adams
Summary: This study examines the use of informal support among people with chronic pain. The results show that individuals who receive informal care are primarily female, older, and have multiple medical conditions. The informal care provided often involves everyday activities and is most frequently provided by partners or children. Despite reporting greater disability and symptoms, there were no differences in health status, loneliness, or well-being between those who received care and those who did not.
BRITISH JOURNAL OF PAIN
(2023)
Article
Health Policy & Services
Marie Claire Annette Van Hout, Flavia Zalwango, Mathias Akugizibwe, Moreen Namulundu Chaka, Charlotte Bigland, Josephine Birungi, Shabbar Jaffar, Max Bachmann, Jamie Murdoch
Summary: This study conducted a qualitative research to explore the experience of women living with HIV, diabetes, and/or hypertension in accessing integrated care in Uganda. The findings revealed five themes including lay health knowledge and alternative medicine, community stigma, experiences of integrated care, navigating personal challenges, and health service constraints.
JOURNAL OF INTEGRATED CARE
(2023)
Article
Health Care Sciences & Services
Marie Claire Van Hout, Flavia Zalwango, Mathias Akugizibwe, Moreen Namulundu Chaka, Josephine Birungi, Joseph Okebe, Shabbar Jaffar, Max Bachmann, Jamie Murdoch
Summary: Sub-Saharan Africa is implementing an integrated care model to provide comprehensive care for patients with HIV, diabetes, and hypertension. The model enhances detection of non-communicable diseases, reduces duplication of care processes, and decreases HIV stigma.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Tharusha D. Gunawardena, Natasha Corballis, Ioannis Merinopoulos, Upul Wickramarachchi, Johannes Reinhold, Clint Maart, Sulfi Sreekumar, Chris Sawh, Trevor Wistow, Toomas Sarev, Alisdair Ryding, Tim J. Gilbert, Allan Clark, Vassilios S. Vassiliou, Simon Eccleshall
Summary: The objective of this study was to compare the outcomes of patients treated with drug-coated balloons (DCBs) or second-generation drug-eluting stents (DESs) for de novo unprotected left main stem (LMS) disease. The results showed that there was no significant difference in all-cause mortality and cardiac mortality between the DCB and DES groups. This suggests that DCB angioplasty can be considered a safe option for the treatment of LMS disease.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Psychology, Developmental
Helen Morse, Amy A. Jolly, Hannah Browning, Allan Clark, Valerie Pomeroy, Stephanie Rossit
Summary: Assessment of cognitive impairments is important in clinical practice, and cancellation and line bisection tasks are commonly used to evaluate visuospatial attention. However, most studies have focused on near-space tasks, and the relationship between cancellation and bisection tasks remains unclear.
AGING NEUROPSYCHOLOGY AND COGNITION
(2023)
Review
Otorhinolaryngology
Shyam A. Gokani, Andreas Espehana, Ana C. Pratas, Louis Luke, Ekta Sharma, Jennifer Mattock, Jelena Gavrilovic, Allan Clark, Tom Wileman, Carl M. Philpott
Summary: This study aimed to identify and summarize clinical studies of biomarkers in adults with chronic rhinosinusitis (CRS) to guide future research into CRS endotypes. The study identified numerous potential biomarkers for differentiating CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2023)
Article
Medicine, Research & Experimental
Linda Birt, Thando Katangwe-Chigamba, Sion Scott, David J. Wright, Adam P. Wagner, Erika Sims, Veronica Bion, Carys Seeley, Faisal Alsaif, Allan Clarke, Alys Griffiths, Liz Jones, Alison Bryant, Amrish Patel
Summary: Influenza vaccination rates among care home staff in the UK are low, but the FluCare study aims to improve this through behavioral interventions such as videos, posters, leaflets, and on-site vaccination clinics. This paper outlines the planned process evaluation, which will describe the intervention's delivery, explore its effects, investigate the mechanisms of impact, and assess the perceived effectiveness of the intervention components from participant perspectives.
Review
Medicine, General & Internal
Sion Scott, Bethany Atkins, Jacqueline M. Martin-Kerry, Megan Pritchard, David Phillip Alldred, Allan B. Clark, Antony Colles, Amber Hammond, Katherine Murphy, Victoria L. Keevil, Ian Kellar, Martyn Patel, Erika Sims, Johanna Taylor, David Turner, Miles Witham, David Wright, Debi Bhattacharya
Summary: The CHARMER study aims to develop and test a behavior change intervention to proactively deprescribe inappropriate medicines with older adults in hospital. This study will test the feasibility and acceptability of study processes and CHARMER implementation.
Article
Medicine, General & Internal
Shyam Ajay Gokani, Allan Clark, Amin Javer, Carl Philpott
Summary: This study aimed to evaluate factors associated with non-adherence to prescribed medication after endoscopic sinus surgery (ESS) and compare SNOT-22 scores post-operation between adherent and non-adherent patients. Of the 94 participants included in this retrospective cohort study, 66% did not adhere to their post-operative medication regimen. The most common reasons for non-adherence were symptom improvement, symptom deterioration, and side effects. Non-intentionally non-adherent (NINA) participants had lower post-operative SNOT-22 scores compared to intentionally non-adherent (INA) and adherent patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Kala Kumaresan, Sara Bengtsson, Saber Sami, Allan Clark, Thomas Hummel, James Boardman, Juliet High, Rashed Sobhan, Carl Philpott
Summary: Smell loss is a common problem, and viral infections are the second most common cause. Smell loss can have negative impacts on quality of life, and effective therapeutic treatment options are lacking. Previous studies suggest the regenerative potential of vitamin A in olfactory receptor neurons. This study aims to compare intranasally delivered vitamin A with no intervention to determine its efficacy.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Respiratory System
Rebecca Ferris, Tun Maung, Christopher Atkins, Dayle Terrington, Allan Clark, Prasad Manivarmane, Andrew Wilson
Summary: This study aimed to test the repeatability of three patient reported outcome measures in people with sarcoidosis associated fatigue. The results showed good agreement between the baseline and 3-month measurements, indicating that these measures are reliable in assessing fatigue and health-related quality of life in this population over a period of 12 weeks.
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
(2023)