期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 143, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112210
关键词
HLA complex group 11; Cancer; LncRNAs; MicroRNAs; Cell proliferation
资金
- Science and Technology Research Project of Henan Province [202102310074]
- Henan Medical Science and Technology Joint Building Program [LHGJ20200282]
HLA plays a critical role in various diseases, while HCG11, a lncRNA, acts as a key regulator in different types of cancers. Research has focused on the role of HCG11 in cancer and its interactions with other molecules.
HLA is critical in a variety of diseases, including infectious disease and cancer, and has been used for diagnostic differentiation and immunosurveillance of certain diseases. In addition, emerging evidence suggests that the mutations and dysregulation of lncRNAs are essential contributors in cancers. HLA Complex Group 11 (HCG11) located on MHC region is affiliated with the lncRNA class. Studies have shown that HCG11 could serve as a key regulator in lung cancer, prostate cancer, glioma, cervical cancer and hepatocellular carcinoma. In this review, we summarize the accumulated information on the expression and clinical value of HCG11 in different cancer types, discuss its interactions with microRNAs, mRNAs, and proteins, and discover the biological roles and po-tential mechanisms of HCG11 in a variety of cellular functions, including cell proliferation, apoptosis, migration, and invasion. Further, we emphasize the possible application of HCG11 in treatment, summarize the studies of HCG11 in chemotherapy resistance and hormone therapy, and propose the significance of further study of HCG11.
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