The ATP level in the medial prefrontal cortex regulates depressive-like behaviour via the mPFC-LHb pathway

Chronic stress induces sex-specific functional and morphological alterations in cortico-accumbal and cortico-tegmental pathways

(2021) Thibault P. Bittar et al.   BIOLOGICAL PSYCHIATRY

Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex

(2021) Minghui Wang et al.   NEURON

Prefrontal–Limbic Connectivity in Depressive Behavior: Sex as a Critical Factor

(2021) Travis M. Moschak   BIOLOGICAL PSYCHIATRY

Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

(2021) Qian Wang et al.   Nature Communications

Networks of habenula-projecting cortical neurons regulate cocaine seeking

(2021) Victor P. Mathis et al.   Science Advances

Hippocampal CD 39/ ENTPD 1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP

(2020) Qian‐Qian Cui et al.   EMBO REPORTS

Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

(2020) Brendan D. Hare et al.   MOLECULAR PSYCHIATRY

Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

(2020) Peng Chen et al.   NEURON

Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula

(2020) Yan-Fei Guan et al.   BRAIN BEHAVIOR AND IMMUNITY

Circuits and functions of the lateral habenula in health and in disease

(2020) Hailan Hu et al.   NATURE REVIEWS NEUROSCIENCE

Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety

(2020) Wei-Zhu Liu et al.   Nature Communications

Transcription Factor TWIST1 Integrates Dendritic Remodeling and Chronic Stress to Promote Depressive-like Behaviors

(2020) Jin-Gang He et al.   BIOLOGICAL PSYCHIATRY

A discrete serotonergic circuit regulates vulnerability to social stress

(2020) Wen-Jun Zou et al.   Nature Communications

A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy

(2019) Lu Huang et al.   NEURON

SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

(2019) Yun Lei et al.   MOLECULAR PSYCHIATRY

Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors

(2019) Wenchao Xiong et al.   JOURNAL OF NEUROSCIENCE

GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

(2019) Danielle M. Gerhard et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior

(2018) Madhurima Benekareddy et al.   BIOLOGICAL PSYCHIATRY

Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats

(2018) Boldizsár Czéh et al.   Frontiers in Cellular Neuroscience

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

(2018) Manao Kinoshita et al.   EBioMedicine

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex

(2018) Hyeonwi Son et al.   NEUROPHARMACOLOGY

The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology

(2018) Emily L. Belleau et al.   BIOLOGICAL PSYCHIATRY

Inositol 1,4,5-trisphosphate receptor type 2-independent Ca2+ release from the endoplasmic reticulum in astrocytes

(2018) Yohei Okubo et al.   GLIA

Astrocytic IP3Rs: Contribution to Ca2+signalling and hippocampal LTP

(2017) Mark William Sherwood et al.   GLIA

Social Isolation During Adolescence Induces Anxiety Behaviors and Enhances Firing Activity in BLA Pyramidal Neurons via mGluR5 Upregulation

(2017) Song Lin et al.   MOLECULAR NEUROBIOLOGY

Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors

(2017) M Jun et al.   MOLECULAR PSYCHIATRY

Prefrontal cortical control of a brainstem social behavior circuit

(2017) Tamara B Franklin et al.   NATURE NEUROSCIENCE

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

(2017) Zhibing Tan et al.   Nature Communications

Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system

(2017) Katja Weckmann et al.   Scientific Reports

Chronic Stress Increases Prefrontal Inhibition: A Mechanism for Stress-Induced Prefrontal Dysfunction

(2016) Jessica M. McKlveen et al.   BIOLOGICAL PSYCHIATRY

Lrp4 in astrocytes modulates glutamatergic transmission

(2016) Xiang-Dong Sun et al.   NATURE NEUROSCIENCE

Serotonin neurons in the dorsal raphe nucleus encode reward signals

(2016) Yi Li et al.   Nature Communications

Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress

(2016) K Ma et al.   Translational Psychiatry

Prefrontal glucose metabolism in medication-resistant major depression

(2015) Cheng-Ta Li et al.   BRITISH JOURNAL OF PSYCHIATRY

Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist

(2015) Yukihiko Shirayama et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

(2015) Jimmy George et al.   GLIA

Depression of Excitatory Synapses onto Parvalbumin Interneurons in the Medial Prefrontal Cortex in Susceptibility to Stress

(2015) Z. Perova et al.   JOURNAL OF NEUROSCIENCE

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

(2015) Daniel J Urban et al.   NEUROPSYCHOPHARMACOLOGY

Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors

(2015) Anne Teissier et al.   Cell Reports

Synaptic Modifications in the Medial Prefrontal Cortex in Susceptibility and Resilience to Stress

(2014) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of  FosB

(2014) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Opposing Effects of Acute versus Chronic Blockade of Frontal Cortex Somatostatin-Positive Inhibitory Neurons on Behavioral Emotionality in Mice

(2014) Amelie Soumier et al.   NEUROPSYCHOPHARMACOLOGY

Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat

(2014) Collin Challis et al.   Frontiers in Behavioral Neuroscience

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

(2014) Ulyana Lalo et al.   PLOS BIOLOGY

Time-dependent metabolomic profiling of Ketamine drug action reveals hippocampal pathway alterations and biomarker candidates

(2014) K Weckmann et al.   Translational Psychiatry

Complete Normalization of Severe Brain 18F-FDG Hypometabolism Following Electroconvulsive Therapy in a Major Depressive Episode

(2013) Cédrik Lajoie et al.   CLINICAL NUCLEAR MEDICINE

Potentiation of Inhibitory Synaptic Transmission by Extracellular ATP in Rat Suprachiasmatic Nuclei

(2013) A. Bhattacharya et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response

(2013) James W. Murrough et al.   PSYCHOPHARMACOLOGY

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

(2012) James W. Murrough et al.   BIOLOGICAL PSYCHIATRY

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

(2012) Melissa R. Warden et al.   NATURE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Circadian Regulation of ATP Release in Astrocytes

(2011) L. Marpegan et al.   JOURNAL OF NEUROSCIENCE

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

Grand challenges in global mental health

(2011) Pamela Y. Collins et al.   NATURE

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder

(2010) Giacomo Salvadore et al.   NEUROIMAGE

ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation

(2010) Y.-J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression

(2009) Brent P. Forester et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Neurocircuitry of Mood Disorders

(2009) Joseph L Price et al.   NEUROPSYCHOPHARMACOLOGY

Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making

(2009) E. Dias-Ferreira et al.   SCIENCE

Brain Bioenergetics and Response to Triiodothyronine Augmentation in Major Depressive Disorder

(2008) Dan V. Iosifescu et al.   BIOLOGICAL PSYCHIATRY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE