Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Testing of the Survivin Suppressant YM155 in a Large Panel of Drug-Resistant Neuroblastoma Cell Lines

(2020) Martin Michaelis et al.   Cancers

ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells

(2019) Yujiao Wu et al.   Cell Death & Disease

The 26S Proteasome Utilizes a Kinetic Gateway to Prioritize Substrate Degradation

(2019) Jared A.M. Bard et al.   CELL

Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model

(2019) Claudia Christowitz et al.   BMC CANCER

Cancer treatment and survivorship statistics, 2019

(2019) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma

(2019) Xiaoqin Fan et al.   CANCER BIOLOGY & THERAPY

Nuclear degradation dynamics in a nonapoptotic programmed cell death

(2019) Alla Yalonetskaya et al.   CELL DEATH AND DIFFERENTIATION

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

A way to understand idiopathic senescence and apoptosis in primary glioblastoma cells – possible approaches to circumvent these phenomena

(2019) Karolina Janik et al.   BMC CANCER

The emergence of drug resistance to targeted therapies: Clinical evidence

(2019) Ana Bela Sarmento-Ribeiro et al.   DRUG RESISTANCE UPDATES

The multi-factorial nature of clinical multidrug resistance in cancer

(2019) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

(2019) Alessandro Leonetti et al.   DRUG RESISTANCE UPDATES

Natural products as multidrug resistance modulators in cancer

(2019) Amit Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Systemic Therapy for Locally Advanced and Metastatic Non–Small Cell Lung Cancer

(2019) Kathryn C. Arbour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death

(2019) Evgeniia A. Prokhorova et al.   ONCOGENE

Dominant-negative ATF5 rapidly depletes survivin in tumor cells

(2019) Xiaotian Sun et al.   Cell Death & Disease

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

(2019) Nirmal Robinson et al.   Redox Biology

Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

(2019) Cody W. Lewis et al.   CANCER RESEARCH

Targeting senescent cells in translational medicine

(2019) Marta Paez‐Ribes et al.   EMBO Molecular Medicine

Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

(2019) Jin Yong Kim et al.   Nature Communications

A novel strategy to block mitotic progression for targeted therapy

(2019) Junlong (Jack) Chi et al.   EBioMedicine

VERU-111 suppresses tumor growth and metastatic phenotypes of cervical cancer cells through the activation of p53 signaling pathway

(2019) Vivek K. Kashyap et al.   CANCER LETTERS

5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells

(2019) Zhaoshi Bai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Non-apoptotic cell death in malignant tumor cells and natural compounds

(2018) Jing Ye et al.   CANCER LETTERS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells

(2018) Zhaoshi Bai et al.   CELL PROLIFERATION

Survivin and autoimmunity; the ins and outs

(2018) Hamidreza Ebrahimiyan et al.   IMMUNOLOGY LETTERS

Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis

(2018) Xianghe Liu et al.   OncoTargets and Therapy

TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14

(2018) Liang Chen et al.   Nature Communications

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

(2018) Seung Hee Jung et al.   ONCOGENE

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis

(2017) Miriam Ejarque et al.   Cell Death & Disease

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway

(2016) Jingwen Xu et al.   CANCER LETTERS

Multiple facets of p53 in senescence induction and maintenance

(2016) Yoshikazu Johmura et al.   CANCER SCIENCE

Mitotic catastrophe and cancer drug resistance: A link that must to be broken

(2016) Tatiana V. Denisenko et al.   DRUG RESISTANCE UPDATES

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Autophagic Turnover of Inactive 26S Proteasomes in Yeast Is Directed by the Ubiquitin Receptor Cue5 and the Hsp42 Chaperone

(2016) Richard S. Marshall et al.   Cell Reports

The ERK/eIF4F/Bcl-XL pathway mediates SGP-2 induced osteosarcoma cells apoptosis in vitro and in vivo

(2014) Zhenzhen Zhang et al.   CANCER LETTERS

Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair

(2014) Qin Qin et al.   Journal of Hematology & Oncology

Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

(2014) Sharad Sharma et al.   Molecular Oncology

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

(2014) Georg E Winter et al.   Nature Chemical Biology

YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels

(2012) B. Kumar et al.   MOLECULAR CANCER THERAPEUTICS

YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model

(2011) Takahito Nakahara et al.   ANTI-CANCER DRUGS

Survivin and escaping in therapy-induced cellular senescence

(2010) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Radiation-Induced Survivin Nuclear Accumulation is Linked to DNA Damage Repair

(2010) Gianni Capalbo et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21waf1/cip1 expression and lack of polyploidy

(2009) Magdalena Dabrowska et al.   CANCER LETTERS