PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3

Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

(2019) Shuai Zhang et al.   Cell Death & Disease

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

(2019) Changliang Shan et al.   Cell Death & Disease

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation

(2019) Hao Sheng et al.   CARCINOGENESIS

The role of STAT3 in leading the crosstalk between human cancers and the immune system

(2018) Yu Wang et al.   CANCER LETTERS

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer

(2017) Wujian Zheng et al.   Frontiers in Pharmacology

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity

(2015) S Zhang et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

The roles of PIKE in tumorigenesis

(2013) Qi Qi et al.   ACTA PHARMACOLOGICA SINICA

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

(2013) Wenjing Du et al.   NATURE CELL BIOLOGY

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY