Article
Behavioral Sciences
Aline M. Dantas, Alexander T. Sack, Elisabeth Bruggen, Peiran Jiao, Teresa Schuhmann
Summary: This study investigated the effects of noninvasive brain stimulation on risk-taking behavior by stimulating the right dorsolateral prefrontal cortex (rDLPFC) and ventromedial prefrontal cortex (VMPFC). The results showed that stimulating either rDLPFC or VMPFC led to an increase in risk-taking behavior and the average value chosen, with no effect on probability choice. Additionally, inhibiting rDLPFC resulted in increased response time. These findings suggest a strong anatomical and functional interconnection between rDLPFC and VMPFC.
Article
Neurosciences
Lin Zhu, Ge Dang, Wei Wu, Junhong Zhou, Xue Shi, Xiaolin Su, Huixia Ren, Zian Pei, Xiaoyong Lan, Chongyuan Lian, Peng Xie, Yi Guo
Summary: This study investigated the mechanisms underlying the efficacy of repetitive transcranial magnetic stimulation (rTMS) in chronic insomnia disorder (CID) and found that alterations in functional connectivity were associated with clinical outcomes. Specifically, rTMS treatment significantly increased connectivity in a specific frequency band and the changes in connectivity were related to improvement in insomnia symptoms. These findings provide preliminary evidence for prospective clinical trials and treatment optimization.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Christin Scholz, Hang-Yee Chan, Russell A. Poldrack, Denise T. D. de Ridder, Ale Smidts, Laura Nynke van der Laan
Summary: Self-control is crucial for human wellbeing, and Hare et al.'s study on the neural correlates of self-control has made a significant impact. To support the self-control theory, a replication study was conducted, which found that decision-making is associated with value signals in the vmPFC. Contrary to the hypothesis, the study did not find a significant role for the dlPFC in self-control. Additionally, the results show that the analytical strategy can affect the findings.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Haotian Ye, Muhuo Ji, Chaoyan Wang, Cong Wang, Ying Li, Yuan Chen, Lisha Cheng, Yanfei Li, Jian-Jun Yang
Summary: Sleep deprivation after night shift work may lead to depressive tendencies in ICU medical staff, which may be related to alterations in the medial prefrontal cortex, increased HAMD scores, and changes in monoamine neurotransmitters.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Jing Qi, Bo-Zhi Li, Ying Zhang, Bei Pan, Yu-Hong Gao, Hao Zhan, Yong Liu, Yong-Cong Shao, Xi Zhang
Summary: This study investigated alterations in hypothalamic functional connectivity following total sleep deprivation in 30 healthy adult males. Enhanced connectivity was observed between the hypothalamus and various brain regions, but a significant correlation between altered hypothalamic connectivity and vigilance performance was not found.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Mark W. Logue, Zhenwei Zhou, Filomene G. Morrison, Erika J. Wolf, Nikolaos P. Daskalakis, Christos Chatzinakos, Foivos Georgiadis, Adam T. Labadorf, Matthew J. Girgenti, Keith A. Young, Douglas E. Williamson, Xiang Zhao, Jaclyn Garza Grenier, Bertrand Russell Huber, Mark W. Miller
Summary: This study identified several novel PTSD-associated genes and brain region-specific PTSD-associated immune-related networks. Replication of dlPFC associations in an independent cohort from a recent study showed a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies.
NEUROBIOLOGY OF STRESS
(2021)
Article
Clinical Neurology
Jing Qi, Bo-Zhi Li, Ying Zhang, Bei Pan, Yu-Hong Gao, Hao Zhan, Yong Liu, Yong-Cong Shao, Xi Zhang
Summary: This study found that after total sleep deprivation, there were significant alterations in insular functional connectivity, with enhanced connectivity with the prefrontal cortex and inferior temporal gyrus, while reduced connectivity with temporal, parietal, and occipital regions. Furthermore, the changes in insular functional connectivity were correlated with PVT performance.
Article
Clinical Neurology
Sisi Zheng, Sitong Feng, Hao Yao, Linrui Dong, Zhengtian Feng, Xinzi Liu, Binlong Zhang, Hongxiao Jia, Yanzhe Ning
Summary: We used a combination of meta-analysis and functional connectivity analysis to identify potential targets for non-invasive brain stimulation (NIBS) in young individuals with acute sleep deprivation. The results revealed several specific brain regions that could potentially be stimulated using NIBS to intervene in acute sleep deprivation.
Article
Biochemistry & Molecular Biology
Yangyang Wang, Xuhong Yang, Lifei Xiao, Wenchao Li, Xianhao Huo, Chaofan Wang, Mei Li, Tao Sun
Summary: Sleep deprivation is a significant cause of cognitive impairment. This study investigated the relationship between functional connectivity of anterior insular subregions and cognitive impairment following total sleep deprivation. The results suggest that altered functional connectivity in these subregions may serve as a neuroimaging biomarker for cognitive impairment after sleep deprivation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Nao-Xin Huang, Zhu-Ling Gao, Jia-Hui Lin, Yan-Juan Lin, Hua-Jun Chen
Summary: Sleep deprivation can alter the stability of the brain's functional architecture and may have implications for various neurocognitive domains.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Jie Chen, Xinxin Gong, Letong Wang, Mengmeng Xu, Xiao Zhong, Ziyi Peng, Tao Song, Lin Xu, Jie Lian, Yongcong Shao, Xiechuan Weng
Summary: This study found that sleep deprivation leads to decreased risk perception and is associated with changes in communication between brain regions. Sleep deprivation increased regional homogeneity in the right postcentral gyrus and this increase was positively correlated with changes in risk perception. Furthermore, functional connectivity between the right postcentral gyrus, left medial temporal gyrus, and right inferior temporal gyrus was enhanced, and this enhanced connectivity was positively correlated with changes in risk perception.
Article
Clinical Neurology
Yanzhe Ning, Sisi Zheng, Sitong Feng, Hao Yao, Zhengtian Feng, Xinzi Liu, Linrui Dong, Hongxiao Jia
Summary: Acupuncture has been shown to improve sleep quality and cognitive function in individuals with insufficient sleep. This study found that acupuncture can modulate extensive brain networks and reverse the altered functional connectivity in individuals after acute sleep deprivation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Ying Zhang, Cimin Dai, Yongcong Shao, Jiaxi Peng, Yan Yang, Yanhong Hou
Summary: This study found that sleep deprivation decreases functional connectivity within the reward network, which may be associated with enhanced negative emotional experience found after total sleep deprivation.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Jinbo Sun, Rui Zhao, Zhaoyang He, Mengying Chang, Fumin Wang, Wei Wei, Xiaodan Zhang, Yuanqiang Zhu, Yibin Xi, Xuejuan Yang, Wei Qin
Summary: This study used a novel metric to examine the dynamic functional connectivity in the brain after sleep deprivation. The results showed that sleep-deprived subjects exhibited abnormal brain functional configuration, providing new insights into the neural underpinnings of sleep deprivation and the pathophysiology of clinical disorders.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Sitong Feng, Hao Yao, Sisi Zheng, Zhengtian Feng, Xinzi Liu, Rui Liu, Linrui Dong, Yongli Cai, Hongxiao Jia, Yanzhe Ning
Summary: This study aimed to investigate the impact of acute sleep deprivation on working memory (WM) and identified abnormal brain functions within the WM network. The results showed decreased activation in certain brain regions during WM tasks after sleep deprivation and a negative correlation between increased functional connectivity in the WM network and impaired WM performance.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)