Article
Biochemistry & Molecular Biology
Haoren Qin, Heng Zhang, Xipeng Zhang, Shiwu Zhang, Siwei Zhu, Hui Wang
Summary: Resveratrol can protect against radiation-induced intestinal injury by inhibiting oxidative stress and apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Jianghui Li, Hui Long, Yanyan Cong, Hongyuan Gao, Qifeng Lyu, Sha Yu, Yanping Kuang
Summary: Quercetin attenuates cyclophosphamide-induced follicle loss by preventing the phosphorylation of PI3K/Akt/Foxo3a pathway members and maintaining the anti-Mullerian hormone level through reduced apoptosis in growing follicles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yingying Chen, Yueyue Xi, Milu Li, Yaling Wu, Wei Yan, Jun Dai, Mingfu Wu, Wenjun Ding, Jinjin Zhang, Fang Zhang, Su Zhou, Shixuan Wang
Summary: There is evidence to suggest that maternal exposure to ambient PM2.5 negatively affects ovarian function in offspring. This study found that exposure to PM2.5 reduced the size of the primordial follicle pool and impaired its development in mice. It also activated primordial follicles and increased oxidative stress-related genes in offspring mice. The findings suggest a link between maternal PM2.5 exposure and ovarian reserve in offspring.
Article
Biochemistry & Molecular Biology
Li-Li Zhu, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Zhao-Qing Meng, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: This study investigated the cardioprotective effect of Muscone on AMI rats and found that Muscone significantly reduced myocardial injury, improved cardiac function, and exerted protective effects by inhibiting oxidative stress and apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu
Summary: l-Arginine has been shown to reduce muscle injury by regulating the SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways as a potential nutraceutical.
Article
Biotechnology & Applied Microbiology
Haitao Tu, Duanhua Ma, Yuanyuan Luo, Shuifu Tang, Ying Li, Gangyi Chen, Liangliang Wang, Zhengkun Hou, Chuangpeng Shen, Huan Lu, Xun Zhuang, Liangyou Zhang
Summary: This study demonstrates the significant therapeutic effect of Quercetin on chronic renal failure (CRF) by regulating the PI3K/Akt pathway to reduce cell apoptosis, water retention, and toxin accumulation. Quercetin, as the main ingredient of SQJZJN, may minimize renal fibrosis and apoptosis in CRF rats through targeting PIK3R1.
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Neurosciences
Manish Kumar, Nitin Bansal
Summary: Alzheimer's disease is a prevalent type of dementia in the elderly population, with complex pathophysiological processes involving cell apoptosis, tauopathy, beta-amyloidopathy, etc. Despite significant advancements in understanding the pathogenesis, treatment remains a challenge. The PI3K-Akt pathway may serve as a crucial therapeutic target in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yanhui Liu, Haobo Kong, Heping Cai, Guanru Chen, Huiying Chen, Wenyi Ruan
Summary: This paper reviews the association between the PI3K/Akt pathway and COPD, aiming to identify new therapeutic targets for clinical intervention in this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Liying Song, Kun Pan, Xihao Du, Shuo Jiang, Xuejiao Zeng, Jia Zhang, Lei Lei, Mengdi Zhang, Yuwen Zhang, Dongxia Fan, Zhixiu Liu, Ji Zhou, Jinzhuo Zhao
Summary: The experiment demonstrated that exposure to PM2.5 can lead to changes in neurobehavior and brain structure in mice, affecting learning and memory abilities; a decrease in albumin and SOD in serum may be related to neural damage; exposure to PM2.5 may activate the PI3K/AKT/FoxO1 pathway, resulting in brain injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biology
Haoran Zhu, Keefe T. Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna S. Trigos, Dovile Anderson, Darren J. Creek, David P. De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B. Pearson, Jian Kang
Summary: This study reveals that upregulated CBS expression and enhanced uptake of cysteine protects cells undergoing AKT-induced senescence from oxidative stress-induced cell death. CBS depletion allows cells to escape senescence and re-enter the cell cycle, indicating the importance of CBS activity in maintaining senescence. CBS expression is suppressed in human gastric cancer cells with activated PI3K/AKT signaling. CBS loss cooperates with activated PI3K/AKT signaling to promote anchorage-independent growth of gastric epithelial cells, while CBS restoration suppresses the growth of gastric tumors in vivo.
Article
Immunology
Zhao Fang, Yushanjiang Feierkaiti, Guangji Wang, Xiaoxin Zheng, Xuejun Jiang
Summary: This study aimed to investigate the protective effect of germacrone against cardiac remodeling. The results showed that germacrone could attenuate oxidative stress, inflammation, and apoptosis induced by cardiac remodeling by inhibiting the PI3K/AKT pathway, thus representing a promising therapeutic approach for the treatment of cardiac remodeling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Haoyue Huang, Yaping Liu, Ze Xu, Dongdong Zhang, Mingming Feng, Tong Zhao, Luoya Zhang, Wenjie Li, Xing Li
Summary: The study found that fucoidan could improve renal injury in type 2 diabetic rats through antioxidant mechanism, possibly related to the activation of PI3K/AKT/Nrf2 signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Huali Chen, Zelin Zhang, Jiaxin Duan, Rongmao Hua, Xiaodi Li, Li Yang, Jianyong Cheng, Qingwang Li
Summary: This study investigated the therapeutic effect of isorhamnetin on ZEA-induced damage in porcine ovarian granulosa cells and elucidated its molecular mechanism. The results showed that isorhamnetin protected ovarian granulosa cells from ZEA-induced damage, promoting proliferation and alleviating apoptosis, endoplasmic reticulum stress, oxidative stress, and steroidogenesis disorder.
Article
Biochemistry & Molecular Biology
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study found that glucosamine can protect porcine trophectoderm (pTr) cells from apoptosis and oxidative damage induced by zearalenone. Further research suggests that glucosamine exerts its protective effect by activating the PI3K/AKT signaling pathway. These findings provide a theoretical basis for the application of glucosamine in alleviating impaired early embryo development.
