Article
Agronomy
Manuel Tejada, Marina del Toro, Patricia Paneque, Isidoro Gomez, Juan Parrado, Concepcion Benitez
Summary: This manuscript assesses the impact of a prolonged 75-day drought on the behavior of MCPA herbicide and biochemical properties in three agricultural soils. The results show that soil moisture content affects the degradation of MCPA and biochemical properties differently.
Article
Electrochemistry
Tian Yu, Orla Fenelon, Karen M. Herdman, Carmel B. Breslin
Summary: In this study, a sensor was fabricated by activating a glassy carbon electrode (GCE) in an aqueous phosphate solution. The activated GCE exhibited excellent detection of MCPA with good reproducibility and stability. The sensor also showed good selectivity in the presence of other compounds.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Kamil Ciarka, Radoslaw Olszewski, Tadeusz Praczyk, Juliusz Pernak
Summary: Ten ionic liquids with varying substitution patterns and alkyl chain lengths were synthesized and characterized for their physicochemical properties, followed by testing their herbicidal activity against cornflower under greenhouse conditions.
Article
Environmental Sciences
Xuan Zhang, Keke Geng, Ningning Wu, Gang Hu, Ben Fan, Jian He, Wenjing Qiao
Summary: In this study, an anaerobic bacterial consortium capable of degrading MCPA was enriched from river sediment. After 6 months of acclimation, the consortium achieved a MCPA transformation rate 25 times faster than the original sludge. The bacterial community composition also showed a significant shift and correlated positively with the anaerobic degradation of MCPA. This research provides a basis for further understanding of the anaerobic catabolism of MCPA and contributes to the development of efficient and low-cost anaerobic treatment technologies for MCPA pollution.
Article
Materials Science, Multidisciplinary
L. Prodan, I. Filippova, A. O. Zubtsovskii, S. Shova, S. Widmann, A. A. Tsirlin, I. Kezsmarki, V. Tsurkan
Summary: We investigate the crystal structure, magnetization, and specific heat measurements of single crystals of the hexagonal polar magnet Co2-xZnxMo3O8. It is found that Zn doping can preserve the robust antiferromagnetic behavior in Co2Mo3O8 up to x = 0.55. The observed effects in the lattice parameter, Curie-Weiss temperature, and magnetic entropy can be attributed to the site-selective Zn substitution, which is dependent on the coordination of the Co2+ ions.
Article
Multidisciplinary Sciences
Hamza Ahmad Isiyaka, Khairulazhar Jumbri, Nonni Soraya Sambudi, Zakariyya Uba Zango, Bahruddin Saad, Adamu Mustapha
Summary: This study demonstrates the effective removal of MCPA from water using hydrothermally synthesized MIL-101(Cr) MOF, with rapid removal rate and high reusability. The properties of the MOF were thoroughly characterized, and an artificial neural network model was utilized for accurate prediction.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Plant Sciences
Quan-Cheng Zhang, Jing Wang, Jun-Gang Wang
Summary: The study investigated the effects of MPCA-Na on cotton plants at different growth stages and evaluated the use of plant growth regulators to mitigate the herbicide damage. Results showed that MPCA-Na exposure affected chlorophyll content, soluble protein content, and enzyme activity, leading to reductions in plant height and boll weight. However, the application of growth regulators alleviated the toxicity and positively impacted the yield of cotton plants.
Article
Medicine, Research & Experimental
Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna J. Magliozzi, Prafulla C. Gokhale, Vijaya G. Tirunagaru, Robert C. Doebele, James A. DeCaprio
Summary: In this study, the efficacy of milademetan, an MDM2 inhibitor, was assessed in various MCC models, showing significant inhibition on WT p53 MCC tumors. Useful in vitro and in vivo models for future MCC studies were also reported.
Article
Biochemistry & Molecular Biology
Kamila Buzun, Agnieszka Gornowicz, Roman Lesyk, Anna Kryshchyshyn-Dylevych, Andrzej Gzella, Robert Czarnomysy, Gniewomir Latacz, Agnieszka Olejarz-Maciej, Jadwiga Handzlik, Krzysztof Bielawski, Anna Bielawska
Summary: This study focused on the synthesis of hybrid molecules for the design of potential anticancer agents, specifically a novel 4-thiazolidinone derivative named Les-3331. Les-3331 demonstrated high cytotoxic and antiproliferative activity in breast cancer cells, through mechanisms involving apoptosis induction, decreased mitochondrial membrane potential, and increased caspase-9 and caspase-8 concentrations. The compound also reduced the concentrations of LC3A, LC3B, Beclin-1, and topoisomerase II. In vitro assays confirmed the metabolic pathways and lack of drug-drug interaction risk for Les-3331.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Gulpinar Sarki, Burak Tuzun, Dilek Unluer, Halit Kantekin
Summary: In this study, the structures of tetra substituted phthalocyanines (H2 (2) and CuII (3)) synthesized using 4-(4-(4-methox-yphenethyl)-3-benzyl-5-oxo-4,5-dihydro-1,2,4 triazol-1-yl)phthalonitrile (1) were determined using spectroscopic techniques. The chemical and biological activities of phthalocyanine molecules and its copper metal complex were theoretically compared using Gaussian software and molecular docking calculations. Protein-Ligand Interaction Profiler (PLIP) server was used to determine the interactions between molecules and proteins.
INORGANICA CHIMICA ACTA
(2023)
Article
Cell Biology
Yu-Hsin Chen, Yen-Chou Chen, Yu-Tang Chin, Ching-Chiung Wang, Ling-Ling Hwang, Liang-Yo Yang, Dah-Yuu Lu
Summary: Traumatic brain injury (TBI) is a global health issue that affects at least 10 million people per year. 2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), a compound extracted from the Chinese herb Polygonum multiflorum, has been shown to have protective effects on TBI, reducing injury severity score, promoting motor coordination, improving cognitive performance, and inhibiting apoptosis while promoting neurogenesis.
Article
Biochemistry & Molecular Biology
Jennifer S. S. Strehse, Daniel Hoffmann, Nikolaos Protopapas, Hans-Jorg Martin, Edmund Maser
Summary: This study investigated the products formed during the reduction of 4ONE and 4HNE by Sniffer proteins from Daphnia magna and Daphnia pulex. The results showed that 4HNE is the main product formed from the sniffer-mediated reduction of 4ONE. These findings are important for understanding the reductive metabolism of lipid peroxidation products.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Nicole E. Winchester, Nabin K. Shrestha, Priscilla Kim, Larisa G. Tereshchenko, Michael B. Rothberg
Summary: SARS-CoV-2 infection during Delta predominance did not provide significant protection against BA.4/BA.5 infection and had minimal protection against hospitalization. In contrast, prior infection with BA.1/BA.2 and up-to-date vaccination provided modest protection against BA.4/BA.5 infection and hospitalization.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Dmitry E. E. Shybanov, Maxim E. E. Kukushkin, Yanislav S. S. Hrytseniuk, Yuri K. K. Grishin, Vitaly A. A. Roznyatovsky, Viktor A. A. Tafeenko, Dmitry A. A. Skvortsov, Nikolai V. V. Zyk, Elena K. K. Beloglazkina
Summary: Novel hydantion and thiohydantoin-based spiro-compounds were synthesized via the regioselective and stereoselective Diels-Alder reactions. The reactions with cyclic dienes produced exo-isomers, while the reactions with isoprene yielded less sterically hindered products. The reactions of methylideneimidazolones required heating with cyclopentadiene, but catalysis by Lewis acids with cyclohexadiene, 2,3-dimethylbutadiene, and isoprene. ZnI2 was found to be an effective catalyst in the reactions of methylidenethiohydantoins with non-activated dienes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Bang-Hong Zhang, Wen Bao, Fu Cheng, Ke-Yang Yu, Jia-Xuan Wang, Zi-Hao Zhang, Long-Jun Dong, Ze-Sen Xue, Dao-Yong Zhu, Xue-Tao Xu, Shao-Hua Wang
Summary: A Rh(I)-catalyzed [5 + 2]/[2 + 2] cycloaddition cascade has been developed to efficiently form a complex and highly strained [4-5-6-7] tetracyclic framework with good yields and excellent diastereoselectivities. The formation of three rings, three C-C bonds, and four contiguous stereocenters is achieved through the readily construction of rare sterically congested multi-substituted cyclobutanes using Michael addition and a Mannich reaction cascade.
