Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies

BackgroundPreoperative risk assessment in cancer surgery is of importance to improve treatment and outcome. The aim of this study was to assess the impact of CT-assessed sarcopenia on short- and long-term outcomes in patients undergoing surgical resection of gastrointestinal and hepatopancreatobiliary malignancies. MethodsA systematic search of Embase, PubMed and Web of Science was performed to identify relevant studies published before 30 September 2014. PRISMA guidelines for systematic reviews were followed. Screening for inclusion, checking the validity of included studies and data extraction were carried out independently by two investigators. ResultsAfter screening 692 records, 13 observational studies with a total of 2884 patients were included in the analysis. There was wide variation in the reported prevalence of sarcopenia (170-79 per cent). Sarcopenia was independently associated with reduced overall survival in seven of ten studies, irrespective of tumour site. Hazard ratios (HRs) of up to 319 (hepatic cancer), 163 (pancreatic cancer), 185 (colorectal cancer) and 269 (colorectal liver metastases, CLM) were reported. For oesophageal cancer, the HR was 031 for increasing muscle mass. In patients with colorectal cancer and CLM, sarcopenia was independently associated with postoperative mortality (colorectal cancer: odds ratio (OR) 433), complications (colorectal cancer: OR 096 for increasing muscle mass; CLM: OR 222) and severe complications (CLM: OR 312). ConclusionSarcopenia identified before surgery by single-slice CT is associated with impaired overall survival in gastrointestinal and hepatopancreatobiliary malignancies, and increased postoperative morbidity in patients with colorectal cancer with or without hepatic metastases. Sarcopenia mattered