期刊
IEEE JOURNAL OF SOLID-STATE CIRCUITS
卷 51, 期 1, 页码 259-272出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSSC.2015.2489839
关键词
Biomedical; calibration; complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS); continuous wavelet transform (CWT); deconvolution; micro gas chromatography (mu GC); system-on-chip (SoC); volatile organic compound (VOCs)
资金
- National Taiwan University [NTU-CESRP-104R7624]
- Ministry of Science and Technology, Taiwan [104-2221-E-002-061-MY3, 104-2221-E-002-148-MY2]
With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (mu GC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 mu m 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R-2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.
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