Nickel-catalyzed α-alkylation of ketones with benzyl alcohols

We reported an efficient method for alpha-alkylation of ketones with benzyl alcohols using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts. A wide range of ketones and benzyl alcohols were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives.

Automated summary

An efficient method using pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts for alpha-alkylation of ketones with benzyl alcohols was reported. A wide range of products were obtained in moderate to high yields, and the complexes were also successfully utilized for the synthesis of various quinoline derivatives.