Article
Rheumatology
Viking Huss, Hannah Bower, Karin Hellgren, Thomas Frisell, Johan Askling, ARTIS grp
Summary: This study assessed the cancer risks associated with Janus kinase inhibitors (JAKi) compared to biological disease-modifying antirheumatic drugs (bDMARDs) in clinical practice. The results showed that, in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), the short-term risk of cancers other than non-melanoma skin cancer (NMSC) was not higher with JAKi compared to tumor necrosis factor inhibitors (TNFi), but there was evidence of an increased risk for NMSC.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Maria Laura Acosta Felquer, Luciano LoGiudice, Maria Laura Galimberti, Javier Rosa, Luis Mazzuoccolo, Enrique R. Soriano
Summary: The study found that using biologics in patients with psoriasis can reduce the risk of developing psoriatic arthritis (PsA).
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Paolo Gisondi, Francesco Bellinato, Giovanni Targher, Luca Idolazzi, Giampiero Girolomoni
Summary: In patients with moderate-to-severe chronic plaque psoriasis, treatment with bDMARDs may delay or reduce the risk of incident PsA. The annual incidence rate of PsA was significantly lower in the bDMARDs group compared to the phototherapy group. Factors associated with a higher risk of PsA included older age, nail psoriasis, and psoriasis duration over 10 years.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Florian Lucasson, Uta Kiltz, Umut Kalyoncu, Ying Ying Leung, Penelope Palominos, Juan Canete, Rossana Scrivo, Andra Balanescu, Emanuelle Dernis, Sandra Meisalu, Adeline Ryussen-Witrand, Martin Soubrier, Sibel Zehra Aydin, Lihi Eder, Inna Gaydukova, Ennio Lubrano, Pascal Richette, Elaine Husni, Laura C. Coates, Maarten de Wit, Josef S. Smolen, Ana-Maria Orbai, Laure Gossec
Summary: Patient care for psoriatic arthritis (PsA) can vary across countries. This study found that patients from countries with lower GDP/capita had higher disease activity and worse disease impact, despite similar use of biological disease-modifying antirheumatic drugs (bDMARDs). There is a need for more equitable healthcare.
Article
Rheumatology
Katie L. Druce, Belay Birlie Yimer, Jennifer Humphreys, Lucy N. Njuki, Darryl Bourke, Michael Li, Benjamin Ellis, Yuanyuan Zhang, Ramiro Bravo, Kimme L. Hyrich, Suzanne M. M. Verstappen, William G. Dixon, John McBeth
Summary: Estimates of the epidemiology of Psoriatic Arthritis (PsA) are crucial for healthcare provision, research, and organizational work. A statistical modeling strategy was used to provide contemporary prevalence and incidence estimates for PsA in the UK from 1991 to 2020, showing a significant increase in both prevalence and incidence rates over the past three decades.
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Article
Rheumatology
Madeline Deike, Ralph Brinks, Stephan Meller, Matthias Schneider, Philipp Sewerin
Summary: The study provides a comprehensive analysis of age-dependent risk of PsA, focusing on varying incidences within different age groups. Results show that the incidence of PsA increases with age until a peak slightly before age 60, then declines. Incidence is higher in women than in men, and shows an increasing trend over the survey period.
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Dermatology
Maximilian Reinhardt, Claudia Garbe, Jana Petersen, Matthias Augustin, Natalia Kirsten, Mona H. C. Biermann, Benjamin M. Haeberle, Kristina Hagenstroem
Summary: Psoriatic arthritis is a common manifestation of psoriasis and has a significant impact on physical functioning, work ability and quality of life. A German study found that 2.6% of adult patients with psoriasis developed concomitant psoriatic arthritis within five years. Cardiovascular diseases are the most frequent comorbidity, while depression and neurosis/stress disorder were identified as indicators for the development of psoriatic arthritis.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Dermatology
Maximilian Reinhardt, Claudia Garbe, Jana Petersen, Matthias Augustin, Natalia Kirsten, Mona H. C. Biermann, Benjamin M. Haeberle, Kristina Hagenstroem
Summary: Psoriatic arthritis, a common manifestation of psoriasis, significantly impacts patients' quality of life. Little research has been done on its epidemiology and risk factors, but findings suggest cardiovascular diseases, depression, and neurosis/stress disorder are associated with the development of psoriatic arthritis.
ACTA DERMATO-VENEREOLOGICA
(2021)
Review
Biochemistry & Molecular Biology
Sonia Sundanum, Carl Orr, Douglas Veale
Summary: Psoriatic arthritis (PsA) is a systemic inflammatory condition with multiple clinical manifestations. Despite progress in understanding its pathobiology and emergence of targeted therapies, some patients still do not respond well to current treatments. The heterogeneous nature of the disease and varying disease activity make it challenging to devise management strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Katelynn M. Wilton, Sara J. Achenbach, Paras Karmacharya, Floranne C. Ernste, Eric L. Matteson, Cynthia S. Crowson
Summary: This study found that men with PsA may have an increased risk of ED, but the association was not statistically significant, requiring further research for confirmation.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Pauline Richebe, Guillaume Coiffier, Pascal Guggenbuhl, Denis Mulleman, Marion Couderc, Emanuelle Dernis, Valentine Deprez, Carine Salliot, Saik Urien, Rachel Brault, Adeline Ruyssen-Witrand, Emmanuel Hoppe, Emmanuel Chatelus, Christian Hubert Roux, Sebastien Ottaviani, Marie Baufrere, Alexia Michaut, Loic Pauvele, Christelle Darrieutort-Laffite, Daniel Wendling, Pascal Coquerelle, Geraldine Bart, Elisabeth Gervais, Vincent Goeb, Marc Ardizzone, Edouard Pertuiset, Sophie Derolez, Jean Marc Ziza, Rene-Marc Flipo, Sophie Godot, Raphaele Seror
Summary: This study described the current management and outcome of native joint septic arthritis in French rheumatology departments, revealing a severe prognosis with high morbidity and mortality rates. The study found that management of NJSA was heterogeneous and highlighted the importance of the new French recommendations for facilitating NJSA management.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Medicine, General & Internal
Ivan Giovannini, Alen Zabotti, Carmelo Ciccio, Matteo Salgarello, Lorenzo Cereser, Salvatore De Vita, Ilaria Tinazzi
Summary: The frequent involvement of the spine and sacroiliac joint in Psoriatic Arthritis (PsA) has led to its classification within the Spondyloarthritis group, although a clear distinction between PsA and Spondyloarthritis remains challenging. Axial involvement, ranging from 25 to 70% in PsA patients, must be taken into consideration alongside peripheral involvement for disease management. The lack of consensus in defining axial involvement in PsA has led to varying interpretations over the years, highlighting a need for improved clinical and radiological assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Rheumatology
Chao Zeng, Zidan Yang, Guanghua Lei, Yuqing Zhang
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Saemundur Rognvaldsson, Thorir Einarsson Long, Sigrun Thorsteinsdottir, Thorvardur Jon Love, Sigurdur Yngvi Kristinsson
Summary: This study evaluated the validity of recorded chronic disease diagnoses in Icelandic healthcare registries and found a high positive predictive value, negative predictive value, and accuracy for diagnosing chronic diseases using these registries.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Rheumatology
Ariane Barbacki, Murray Baron, Mianbo Wang, Yuqing Zhang, Wendy Stevens, Joanne Sahhar, Susanna Proudman, Mandana Nikpour, Ada Man
Summary: This study found distinct trajectories of damage accrual in patients with systemic sclerosis, with age, gender, disease type, tendon friction rubs, and C-reactive protein level being associated with the different trajectories. These findings may be helpful in identifying patients who require early aggressive treatment.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Clinical Neurology
Adam M. Kruszewski, Zujaja Tauqeer, Elana A. Meer, Sana Ali Bautista, Neena R. Cherayil, Marcus E. Cimino, Sami L. Khella, Eric Lancaster, Shawn J. Bird, Steven S. Scherer, Karen E. Revere, Ali G. Hamedani, Grant T. Liu, Madhura A. Tamhankar
Summary: This study reports 4 cases of early and progressive vision loss in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), 3 of which were caused by papilledema and 1 by optic neuropathy. The study found that CIDP can present with early vision loss, and treatment may be challenging if diagnosis is delayed.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Elana Meer, Brian J. Nguyen, Sana Bautista, Brendan McGeehan, Maureen G. Maguire, Cesar A. Briceno
Summary: This study aimed to characterize the clinical presentation, surgical management, long-term complications, and outcomes of Gunshot Wounds (GSW) to the orbit. The results demonstrated a long-term burden of persistent pain and reduced visual acuity in patients who suffer from GSW to the globe and orbit, providing guidance for patient management and communication.
OPHTHALMIC EPIDEMIOLOGY
(2023)
Letter
Rheumatology
Telma Thrastardottir, Elana Meer, Arna Hauksdottir, Bjorn Gudbjornsson, Sigurdur Yngvi Kristinsson, Alexis Ogdie, Thorvardur Jon Love
Article
Rheumatology
Hui Li, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Jie Wei, Dongxing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: Patients with rheumatoid arthritis (RA) are at higher risks of SARS-CoV-2 infection and severe outcomes even after COVID-19 vaccination. It is necessary to implement booster COVID-19 vaccinations and other preventive strategies for patients with RA.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Dermatology
Brian J. Nguyen, Elana A. Meer, Sana A. Bautista, Diana H. Kim, Jeremy R. Etzkorn, Brendan McGeehan, Christopher J. Miller, Cesar A. Briceno
Summary: MMS appears to be a beneficial treatment option for facial MCC, preserving tissue without compromising outcomes. Younger age, male sex, and intraoperative detection of in-transit disease were significantly associated with metastasis.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Rheumatology
Zachary S. Wallace, John H. Stone, Xiaoqing Fu, Peter A. Merkel, Eli M. Miloslavsky, Yuqing Zhang, Hyon K. Choi, Emily P. Hyle
Summary: This study developed a simulation model (AAV-Sim) to predict clinical outcomes of fixed and tailored rituximab retreatment strategies in ANCA-associated vasculitis (AAV) patients. The model estimated transition rates, validated internally and externally, and produced consistent results with published data. The AAV-Sim has the potential to inform management guidelines and research priorities.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Zachary S. Wallace, Gandarvaka Miles, Ekaterina Smolkina, Natalia Petruski-Ivleva, Duane Madziva, Claire Cook, Xiaoqing Fu, Yuqing Zhang, John H. Stone, Hyon K. Choi
Summary: This study describes the epidemiology of IgG4-related disease (IgG4-RD) in the USA, finding that the incidence and prevalence of IgG4-RD are increasing, and patients with IgG4-RD have a higher risk of death.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medical Informatics
Elana Meer, Meera S. S. Ramakrishnan, Gideon Whitehead, Damien Leri, Roy Rosin, Brian VanderBeek
Summary: This study developed an online triage tool based on symptoms to address the inefficiency of triage in acute care ophthalmic clinics. The preliminary results show that the tool is able to safely and effectively diagnose patients based on their symptoms.
APPLIED CLINICAL INFORMATICS
(2023)
Review
Multidisciplinary Sciences
Elana Meer, Seanna Grob, Erik L. Antonsen, Aenor Sawyer
Summary: Ocular trauma and conditions in space, such as corneal abrasions, dry eyes, eye debris, ocular irritation, chemical burns, and ocular infections, were reviewed in this literature review based on over 100 articles and NASA evidence books. Unique exposures in spaceflight, including foreign bodies like celestial dust and chemical and thermal injuries from CO2 and heat exposure, were reported. Various diagnostic modalities, such as vision questionnaires, visual acuity testing, fundoscopy, orbital ultrasound, and ocular coherence tomography, were used to evaluate these conditions.
Article
Public, Environmental & Occupational Health
Ziying Wu, Yilun Wang, Yuqing Zhang, Kim L. Bennell, Daniel K. White, Liusong Shen, Wei Ren, Jie Wei, Chao Zeng, Guanghua Lei
Summary: The COVID-19 pandemic has caused a decline in daily steps and physical activity levels. Studies show that over 7000 steps per day is the minimum standard for reducing the risk of all-cause mortality. The confinement period of COVID-19 has led to a significant decrease in daily steps among the general adult population.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Rheumatology
Naomi J. Patel, Xiaoqing Fu, Yuqing Zhang, John H. Stone
Summary: ObjectiveGiant cell arteritis（GCA）requires treatment with high-dose, long-term glucocorticoids (GCs). A score assessing and quantifying patients' baseline GC-related toxicity may be important to risk stratification and therapeutic decision-making in patients initiating immunosuppression. This approach to the assessment of baseline GC-related toxicity distinguished patients with relapsing GCA from those with newly diagnosed disease and may be useful in therapeutic decision-making for patients beginning immunosuppressive treatment.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Rheumatology
Yanqiu Zhu, Jiatian Li, Yuqing Zhang, Weiya Zhang, Michael Doherty, Zidan Yang, Yang Cui, Chao Zeng, Guanghua Lei, Tuo Yang, Jie Wei
Summary: In this population-based study, we found an association between hyperuricaemia and a higher prevalence of hand osteoarthritis.
