Article
Immunology
Giovanni Striani, Ariela Hoxha, Mariagrazia Lorenzin, Giacomo Cozzi, Laura Scagnellato, Tatiana Vangelista, Francesca Frizzera, Pierino De Sandre, Paolo Simioni, Andrea Doria, Roberta Ramonda
Summary: This study investigated the effects of SARS-CoV-2 infection and vaccination in patients with inflammatory arthritis (IA). It found that IA patients who contracted SARS-CoV-2 infection had a higher rate of arthritis flare, and IA patients may also experience flare-ups after SARS-CoV-2 vaccination, although not statistically significant.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sung-Chan Wei, Wei-Ting Hsu, Chun-Hsiang Chiu, Feng-Yee Chang, Huei-Ru Lo, Chuan-Yu Liao, Hwai- Yang, Yu-Chi Chou, Chih-Hsuan Tsai, Yu-Chan Chao
Summary: An integrated detection and vaccination system was developed for COVID-19 control, utilizing recombinant baculoviruses to display virus proteins, which elicited specific antibody responses in animal experiments. This system simplifies operations and improves the efficacy of SARS-CoV-2 detection and vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Caterina Bason, Alessandro Barbieri, Nicola Martinelli, Bianca Olivieri, Giuseppe Argentino, Elena Bartoloni, Ruggero Beri, Gnaneshwer Jadav, Antonio Puccetti, Elisa Tinazzi, Claudio Lunardi
Summary: A specific peptide recognized by RA patients' sera was identified through screening, which was not recognized by healthy subjects or patients with other immune-mediated diseases. This peptide may serve as a novel serum biomarker for seronegative RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Davide Ferrari, Alessandra Mangia, Maria Sestina Spano, Lucia Zaffarano, Marco Vigano, Chiara Di Resta, Massimo Locatelli, Fabio Ciceri, Elena De Vecchi
Summary: This study evaluated the immune response to the first vaccine dose in different sex/age groups and individuals with or without naturally present anti-SARS-CoV-2 antibodies. Naturally seropositive individuals showed stronger vaccine response and longer antibody persistence compared to seronegative individuals. The importance of serological tests in identifying individuals with pre-existing immunity and evaluating vaccine-induced immunity was highlighted.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Review
Immunology
Zichun Wei, Jiarui He, Conghui Wang, Jiaqi Bao, Taiyang Leng, Fei Chen
Summary: Omicron variant, with high transmissibility and lower virulence, has rapidly become the dominant global variant. Vaccination remains a crucial public health priority, despite the underestimation of Omicron's pathogenicity and the increasing hospitalizations and deaths due to its high transmissibility. Mutations in the spike protein, especially in the receptor-binding domain and N-terminal domain, are associated with immune escape and vaccine hesitancy. Therefore, booster dose and third dose vaccination play a vital role in combating the emerging Omicron variant.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ananda M. Rodilla, Sooyun Tavolacci, Jazz Cagan, Tanay Shah, Sandeep Mittan, Philip C. Mack, Fred R. Hirsch
Summary: Compared to the general population, lung cancer patients have a higher risk of severe COVID-19 and associated mortality. Despite being prioritized for vaccination, clinical trials did not include these patients, raising concerns about vaccine efficacy and immune response. Recent investigations have focused on the humoral responses of lung cancer patients to COVID-19 vaccination.
Article
Medicine, General & Internal
Eun Song Kang, Ji Seon Oh, Eun-Ju Lee, Seokchan Hong, Soo Min Ahn, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
Summary: This study investigated the effects of the third dose of the mRNA vaccine on antibody titer and factors associated with antibody production in rheumatoid arthritis (RA) patients who had received two doses of the ChAdOx1-S nCoV-19 vaccine. The study found that the group with the third mRNA vaccine had a higher positive rate of high antibody titers. Multivariate analysis showed that corticosteroid use, older age, and male sex were associated with a lower rate of high antibody titer acquisition after two doses of ChAdOx1-S nCoV-19. Overall, the third dose of the mRNA vaccine could be beneficial for RA patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Immunology
Maurizio Benucci, Arianna Damiani, Francesca Li Gobbi, Barbara Lari, Valentina Grossi, Maria Infantino, Mariangela Manfredi
Summary: This study on 200 patients with rheumatoid arthritis receiving BNT162b2 vaccination found that the background therapy can influence seroconversion, especially for patients treated with ABA and RTX. Despite the booster vaccine, patients under certain treatments had lower levels of anti-SARS CoV-2 IgG.
IMMUNOLOGIC RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Ante Markovinovic, Joshua Quan, Michelle Herauf, Lindsay Hracs, Joseph W. Windsor, Nastaran Sharifi, Stephanie Coward, Lea Caplan, Julia Gorospe, Kenneth Ernest-Suarez, Christopher Ma, Remo Panaccione, Richard J. M. Ingram, Jamil N. Kanji, Graham Tipples, Jessalyn K. Holodinsky, Charles N. Bernstein, Douglas J. Mahoney, Sasha Bernatsky, Eric I. Benchimol, Gilaad G. Kaplan
Summary: SARS-CoV-2 vaccines are safe for patients with IBD, with no cases of IBD flare observed. Injection site reactions after the fourth dose may indicate increased antibody levels.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Infectious Diseases
Jessica Ferguson, Kanagavel Murugesan, Niaz Banaei, Anne Liu
Summary: This case illustrates that some patients may not develop an antibody response after receiving the SARS-CoV-2 vaccine, but can still generate a T cell-mediated immune response.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ayse Unal Enginar
Summary: While most COVID-19 patients have mild symptoms, a small percentage may develop severe pneumonia or even arthritis. Some patients may experience joint pain or arthritis after receiving the COVID-19 vaccine.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
R. Hasseli, A. Pfeil, B. F. Hoyer, A. Krause, H. -M. Lorenz, J. G. Richter, T. Schmeiser, R. E. Voll, H. Schulze-Koops, C. Specker, U. Mueller-Ladner
Summary: This study found that the hospitalization rate during COVID-19 infection was significantly higher in RA patients compared to SpA patients, but there was no significant difference in mortality. This may be due to different treatment strategies or different susceptibilities of the two diseases.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Liat Iancovici, Dina Khateeb, Ofer Harel, Regina Peri, Gleb Slobodin, Yoav Hazan, Doron Melamed, Aharon Kessel, Yotam Bar-On
Summary: This study found that RA patients treated with Janus kinase inhibitors have a suppressed humoral response following BNT162b2 vaccination, as indicated by reduced levels of anti-spike antibodies and neutralization capacity. Additionally, these patients exhibited reduced B cell responsiveness to the SARS-CoV-2 spike protein.
Article
Immunology
Sara Pasquina Pascale, Roberta Nuccorini, Teresa Pierri, Roberta Di Mare, Lucia Fabio, Emilia Lerose, Maria Antonietta Merlino, Pietro Schiavo, Angela Amendola, Gino Brucoli, Maria Denise Caputo, Ida Chitarrelli, Michele Cimminiello, Sabrina Coluzzi, Nunzio Biagio Filardi, Angela Matturro, Domenico Vertone, Monica Poggiaspalla, Francesco Malaspina, Gerardo Musuraca, Gennaro Coralluzzo, Clara Mannarella, Clelia Musto, Angela Pia Bellettieri, Giovanni Martinelli, Claudio Cerchione, Michele Pizzuti
Summary: This study evaluated the serological response of hematological patients after receiving the SARS-CoV-2 vaccine. The results showed that patients with hematological malignancies had lower levels of antibodies, and the response varied according to different therapies and pathologies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Justyna Adamczuk, Piotr Czupryna, Justyna Dunaj-Malyszko, Ewelina Kruszewska, Slawomir Pancewicz, Karol Kaminski, Karol Borawski, Sambor Grygorczuk, Anna Moniuszko-Malinowska
Summary: The study aimed to assess the presence of anti-SARS-CoV-2 antibodies in COVID-19 convalescents and investigate their production in relation to disease severity, sex, vaccination, and correlation with inflammatory parameters. The results showed that immunological response could last over 6 months, with significantly higher antibody titers in severe cases and vaccinated patients. The immunological response was not dependent on sex. There was also a significant correlation between antibody production and the degree of inflammation.
MICROBIOLOGY SPECTRUM
(2022)
Article
Rheumatology
Felix Kartnig, Daniel Mrak, Elisabeth Simader, Selma Tobudic, Helga Radner, Peter Mandl, Lisa Goeschl, Nikolaus Hommer, Margareta Mayer, Philipp Hofer, Thomas Hummel, Thomas Deimel, Irina Gessl, Antonia Puchner, Andreas Kerschbaumer, Renate Thalhammer, Alessandra Handisurya, Renate Kain, Stefan Winkler, Josef S. Smolen, Karin Stiasny, Thomas Perkmann, Helmuth Haslacher, Judith H. Aberle, Daniel Aletaha, Leonhard X. Heinz, Daniela Sieghart, Michael Bonelli
Summary: This clinical trial evaluated the immunogenicity and safety of a third COVID-19 vaccination in patients with immune-mediated inflammatory diseases (IMIDs). The results showed that the third vaccination had good immunogenicity and safety in these patients, but the effects of immunomodulatory therapy should be considered.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medical Laboratory Technology
Tobias Niedrist, Lisa Kriegl, Christoph J. Zurl, Felix Schmidt, Nicole Perkmann-Nagele, Patrick Mucher, Manuela Repl, Ines Flieder, Astrid Radakovics, Daniela Sieghart, Helga Radner, Daniel Aletaha, Christoph J. Binder, Christian Gully, Robert Krause, Markus Herrmann, Oswald F. Wagner, Thomas Perkmann, Helmuth Haslacher
Summary: This study assessed the impact of different storage conditions on anti-NC antibodies and found that short-term storage did not significantly affect the antibodies, while long-term storage may slightly increase their sensitivity.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Immunology
Daniela Sieghart, Claudia A. Hana, Helmuth Haslacher, Thomas Perkmann, Leonhard X. Heinz, Clemens Fedrizzi, Karolina Anderle, Ursula Wiedermann, Irina Condur, Susanne Drapalik, Helmut Steinbrecher, Daniel Mrak, Patrick Mucher, Timothy Hasenoehrl, Andrej Zrdavkovic, Barbara Wagner, Stefano Palma, Galateja Jordakieva, Anselm Jorda, Christa Firbas, Angelika Wagner, Nadja Haiden, Felix Bergmann, Richard Crevenna, Markus Zeitlinger, Michael Bonelli, Daniel Aletaha, Helga Radner
Summary: This multicenter study found vaccine-dependent effects of age and time since full immunization on humoral immune response. The findings highlight the importance of individualized vaccine selection, especially in elderly individuals.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Daniel Mrak, Felix Kartnig, Daniela Sieghart, Elisabeth Simader, Helga Radner, Peter Mandl, Lisa Goeschl, Philipp Hofer, Thomas Deimel, Irina Gessl, Renate Kain, Stefan Winkler, Josef S. Smolen, Thomas Perkmann, Helmuth Haslacher, Daniel Aletaha, Leonhard X. Heinz, Michael Bonelli
Summary: A study found that patients under immunosuppression experienced a rapid decline in antibodies after the third COVID-19 vaccine dose, and it remains unclear whether immunosuppressive therapy affects immune responses. Monitoring the immune response and adverse events in 50 immunosuppressed patients and 42 healthy controls, it was observed that immunosuppressed patients had significantly lower antibody levels, suggesting the need for an early fourth vaccination.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Virology
Thomas Perkmann, Patrick Mucher, Darlene Oesze, Antonia Mueller, Nicole Perkmann-Nagele, Thomas Koller, Astrid Radakovics, Ines Flieder, Manuela Repl, Rodrig Marculescu, Michael Wolzt, Oswald F. Wagner, Christoph J. Binder, Helmuth Haslacher
Summary: This study investigated the comparability of WHO standard referenced commercial SARS-CoV-2 antibody tests after three doses of BNT162b2 vaccine for up to 14 months. The results showed systematic differences between the results of the three antibody binding assays, but the differences decreased over time. IgG-based assays had better agreement with each other but were not interchangeable with the Roche assay. In conclusion, standardization of SARS-CoV-2 antibody binding assays needs improvement for reliable longitudinal analysis.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Rheumatology
Eva Rath, Michael Bonelli, Christina Duftner, Johann Gruber, Peter Mandl, Florentine Moazedi-Furst, Herwig Pieringer, Rudolf Puchner, Holger Flick, Helmut J. F. Salzer, Gunter Weiss, Stefan Winkler, Hans Skvara, Alexander Moschen, Harald Hofer, Julia Feurstein, Judith Sautner
Summary: This nationwide Austrian consensus statement summarizes the recommendations on the management of latent tuberculosis by treatment with biologic and targeted synthetic DMARDs. Experts from various disciplines discussed the essential questions about screening and preventive treatment, and formed a joint consensus based on available data. Different forms of treatment were extensively discussed, and clear recommendations were formulated.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Medicine, General & Internal
Martin Riesenhuber, Christian Nitsche, Christoph J. Binder, Eva S. Schernhammer, Tanja Stamm, Friedrich Jakse, Elaaha Anwari, Fardin Hamidi, Helmuth Haslacher, Thomas Perkmann, Christian Hengstenberg, Thomas A. Zelniker
Summary: This study aimed to estimate and compare the prevalence of anti-SARS-CoV-2 N antibodies in healthcare workers and patients. The results showed that healthcare workers and patients had similar and higher seroprevalence compared to confirmed cases in Austria throughout the pandemic. There was no significant difference in seroprevalence between pediatric and adult patients at different time periods.
Article
Rheumatology
Judith Sautner, Isabella Grabner, Arthur Posch, Christina Duftner
Summary: The study evaluated the "leaky pipeline" phenomenon among female rheumatologists in Europe and analyzed the factors that lead to rheumatologists leaving hospitals. The results showed a significant leaky pipeline effect in the entire sample, with female rheumatologists having lower opportunities and satisfaction levels.
Article
Oncology
Maximilian J. Mair, Agnieszka Maj-Hes, Alina Nussbaumer-Proell, Rainer Puhr, Agnieszka Christenheit, Marlene Troch, Hannah C. Puhr, Angelika M. Starzer, Ariane Steindl, Sabine Eberl, Helmuth Haslacher, Thomas Perkmann, Christoph Minichsdorfer, Gerald W. Prager, Wolfgang W. Lamm, Anna S. Berghoff, Barbara Kiesewetter, Markus Zeitlinger, Matthias Preusser, Markus Raderer
Summary: This study aimed to investigate the preventive effect of azithromycin on COVID-19 infection in cancer patients, but due to low acceptance and low incidence of infection, the study was prematurely closed. Nevertheless, azithromycin had a favorable side effect profile in cancer patients.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Medicine, General & Internal
Selma Tobudic, Elisabeth Simader, Thomas Deimel, Jennifer Straub, Felix Kartnig, Leonhard X. Heinz, Peter Mandl, Helmuth Haslacher, Thomas Perkmann, Lisa Schneider, Thomas Nothnagl, Helga Radner, Florian Winkler, Heinz Burgmann, Karin Stiasny, Gottfried Novacek, Walter Reinisch, Daniel Aletaha, Stefan Winkler, Stephan Blueml
Summary: This study aimed to evaluate the duration of humoral responses after two doses of SARS-CoV-2 mRNA vaccines in patients with inflammatory joint diseases and IBD, and to analyze the factors influencing immune response. The results showed that patients receiving b/tsDMARDs had lower antibody levels and neutralizing antibody titers compared to healthy controls or patients receiving csDMARDs. The decline in antibody levels was faster in patients with b/tsDMARDs, indicating a significantly reduced duration of vaccine-induced immunity. Furthermore, they displayed a reduced response to a booster vaccination, highlighting the need for earlier booster strategies in these patients.
FRONTIERS IN MEDICINE
(2023)
Article
Infectious Diseases
Selma Tobudic, Christina Bahrs, Lisa Schneider, Emilia Paulussen, Lucie Bartonickova, Stefan Hagel, Peter Starzengruber, Heinz Burgmann, Mathias W. W. Pletz
Summary: This study aimed to compare treatment outcomes for bloodstream infections caused by a piperacillin/tazobactam-susceptible E. coli among three patient groups. The results showed that patients with BSI caused by AMP/SLB-resistant isolates treated with another monotherapy had an enhanced early treatment response compared to those treated with PIP/TAZ, indicating a potential association between initial use of PIP/TAZ and reduced treatment response.
Article
Virology
Thomas Perkmann, David N. Springer, Patrick Mucher, Michael Wolzt, Lukas Weseslindtner, Helmuth Haslacher
Summary: This study investigated whether breakthrough infection with SARS-CoV-2 Omicron increases antibody levels in individuals who received three doses of wild-type-based BNT162b2 vaccine. The results suggest that breakthrough infection efficiently boosts wild-type antibodies in vaccinated individuals, while antibody levels decrease in those who received only three doses of the vaccine.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Sebastian Schnaubelt, Julia Oppenauer, Mathias Bader, Na DU, Felix Eibensteiner, Calvin L. Kienbacher, Enrico Baldi, Markus Mueller, Thomas Perkmann, Helmuth Haslacher, Wolfgang Schreiber, Alexander Niessner, Oliver Schlager, Hans Domanovits, Patrick Sulzgruber
Summary: Pulse-wave velocity (PWV) is a non-invasive measurement that can predict cardiovascular pathologies and PCI complexity in patients with acute coronary syndrome (ACS). This study found that pathological PWV was associated with high-risk prediction scores, cardiac enzymes, and three-vessel disease. Additionally, PWV was also related to the complexity of coronary angiography and PCI procedures.
Article
Immunology
Daniela Sieghart, Christian Konrad, Sascha Swiniarski, Helmuth Haslacher, Daniel Aletaha, Guenter Steiner
Summary: This study aimed to investigate the diagnostic performance of anti-CCP2 and anti-CCP3 IgG and IgA assays in patients with early RA, with a focus on the prognostic value of IgA ACPA. The results showed that the anti-CCP2 IgG and IgA assays had high specificity but low sensitivity. The anti-CCP3.1 assay had slightly higher sensitivity but lower specificity compared to the anti-CCP2 IgG assay.
FRONTIERS IN IMMUNOLOGY
(2023)
